(Q45869978)

17 December 2017

title

CTF/NF1 transcription factors act as potent genetic insulators for integrating gene transfer vectors (English)

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17 December 2017

author name string

A Gaussin

1

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17 December 2017

U Modlich

2

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17 December 2017

C Bauche

3

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17 December 2017

N J Niederländer

4

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17 December 2017

A Schambach

5

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17 December 2017

C Duros

6

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17 December 2017

A Artus

7

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17 December 2017

C Baum

8

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17 December 2017

O Cohen-Haguenauer

9

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17 December 2017

N Mermod

10

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17 December 2017

publication date

12 May 2011

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17 December 2017

published in

Gene Therapy

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17 December 2017

volume

19

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17 December 2017

issue

1

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17 December 2017

page(s)

15-24

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17 December 2017

https://scigraph.springernature.com/pub.10.1038/gt.2011.70

exact match

0 references

cites work

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

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https://api.crossref.org/works/10.1038%2FGT.2011.70

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

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Chance or necessity? Insertional mutagenesis in gene therapy and its consequences

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Gene therapy: X-SCID transgene leukaemogenicity

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https://api.crossref.org/works/10.1038%2FGT.2011.70

Transcription start regions in the human genome are favored targets for MLV integration

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

The MDS1-EVI1 gene complex as a retrovirus integration site: impact on behavior of hematopoietic cells and implications for gene therapy

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

Physiological promoters reduce the genotoxic risk of integrating gene vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.70

Transcriptional enhancers induce insertional gene deregulation independently from the vector type and design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.70

Insulators: many functions, many mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.70

Insulators and boundaries: versatile regulatory elements in the eukaryotic genome

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

A group of scs elements function as domain boundaries in an enhancer-blocking assay

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

Putting boundaries on silence

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

Insulator dynamics and the setting of chromatin domains.

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

Development of virus vectors for gene therapy of beta chain hemoglobinopathies: flanking with a chromatin insulator reduces gamma-globin gene silencing in vivo

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

Topological constraints governing the use of the chicken HS4 chromatin insulator in oncoretrovirus vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.70

Retrovirus silencer blocking by the cHS4 insulator is CTCF independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.70

Extended core sequences from the cHS4 insulator are necessary for protecting retroviral vectors from silencing position effects

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

Partial correction of murine beta-thalassemia with a gammaretrovirus vector for human gamma-globin.

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

The protein CTCF is required for the enhancer blocking activity of vertebrate insulators

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

Mechanism of reduction in titers from lentivirus vectors carrying large inserts in the 3'LTR.

21 January 2018

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Lack of shielding of primer binding site silencer-mediated repression of an internal promoter in a retrovirus vector by the putative insulators scs, BEAD-1, and HS4.

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

The 3' region of the chicken hypersensitive site-4 insulator has properties similar to its core and is required for full insulator activity

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

CTCF: master weaver of the genome

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

Insulators: exploiting transcriptional and epigenetic mechanisms

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

The 5'-HS4 chicken beta-globin insulator is a CTCF-dependent nuclear matrix-associated element

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

Reversal of the silencing of tetracycline-controlled genes requires the coordinate action of distinctly acting transcription factors

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

Chromatin domain boundaries delimited by a histone-binding protein in yeast

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

Chicken NFI/TGGCA proteins are encoded by at least three independent genes: NFI-A, NFI-B and NFI-C with homologues in mammalian genomes

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

Identification of a fourth Nuclear Factor I gene in chicken by cDNA cloning: NFI-X

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

Partial purification of a nuclear protein that binds to the CCAAT box of the mouse alpha 1-globin gene

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

Antagonistic regulation of a proline-rich transcription factor by transforming growth factor beta and tumor necrosis factor alpha

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

The histone-interacting domain of nuclear factor I activates simian virus 40 DNA replication in vivo

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

Detection and characterization of silencers and enhancer-blockers in the greater CFTR locus

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.70

High-throughput SELEX SAGE method for quantitative modeling of transcription-factor binding sites.

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

Genome-wide prediction of matrix attachment regions that increase gene expression in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

Transcription factor CTF1 acts as a chromatin domain boundary that shields human telomeric genes from silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.70

Suppression of clonal dominance in cultured human lymphoid cells by addition of the cHS4 insulator to a lentiviral vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.70

Combinatorial incorporation of enhancer-blocking components of the chicken beta-globin 5'HS4 and human T-cell receptor alpha/delta BEAD-1 insulators in self-inactivating retroviral vectors reduces their genotoxic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.70

Characterization of the chicken beta-globin insulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.70

The sea urchin sns5 insulator protects retroviral vectors from chromosomal position effects by maintaining active chromatin structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.70

Integration of retroviral vectors induces minor changes in the transcriptional activity of T cells from ADA-SCID patients treated with gene therapy.

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

Efficient transduction of hemopoietic CD34+ progenitors of human origin using an original retroviral vector derived from Fr-MuLV-FB29: in vitro assessment

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2011.70

DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.70

Overcoming promoter competition in packaging cells improves production of self-inactivating retroviral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.70

Predictable and efficient retroviral gene transfer into murine bone marrow repopulating cells using a defined vector dose

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.70

Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.70

Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.70

inferred from DOI database lookup

7 January 2021

based on heuristic

Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.70

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/GT.2011.70

1 reference

17 December 2017

Dimensions Publication ID

1050187732

0 references

1 reference

17 December 2017