(Q45874701)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25849132%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

title

An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia (English)

1 reference

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4 March 2020

0 references

Alfica Sehgal

1

1 reference

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4 March 2020

Scott Barros

2

1 reference

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4 March 2020

Lacramioara Ivanciu

3

1 reference

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4 March 2020

Brian Cooley

4

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4 March 2020

June Qin

5

1 reference

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4 March 2020

Tim Racie

6

1 reference

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4 March 2020

Julia Hettinger

7

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4 March 2020

Mary Carioto

8

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4 March 2020

Yongfeng Jiang

9

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4 March 2020

Josh Brodsky

10

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4 March 2020

Harsha Prabhala

11

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4 March 2020

Xuemei Zhang

12

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4 March 2020

Husain Attarwala

13

1 reference

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4 March 2020

Renta Hutabarat

14

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4 March 2020

Don Foster

15

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4 March 2020

Stuart Milstein

16

1 reference

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4 March 2020

Klaus Charisse

17

1 reference

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4 March 2020

Satya Kuchimanchi

18

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4 March 2020

Martin A Maier

19

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4 March 2020

Lubo Nechev

20

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4 March 2020

Pachamuthu Kandasamy

21

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4 March 2020

Alexander V Kel'in

22

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4 March 2020

Jayaprakash K Nair

23

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4 March 2020

Kallanthottathil G Rajeev

24

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4 March 2020

Muthiah Manoharan

25

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4 March 2020

Rachel Meyers

26

1 reference

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4 March 2020

Benny Sorensen

27

1 reference

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4 March 2020

Amy R Simon

28

1 reference

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4 March 2020

Rodney M Camire

31

1 reference

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4 March 2020

Akin Akinc

32

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4 March 2020

language of work or name

English

0 references

publication date

13 April 2015

1 reference

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4 March 2020

1 reference

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4 March 2020

volume

21

1 reference

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4 March 2020

issue

5

1 reference

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4 March 2020

page(s)

492-497

1 reference

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https://scigraph.springernature.com/pub.10.1038/nm.3847

4 March 2020

exact match

0 references

cites work

Factor V Leiden and hemophilia

1 reference

Interpatient phenotypic inconsistency in severe congenital hemophilia: a systematic review of the role of inherited thrombophilia

21 January 2018

1 reference

Milder clinical presentation of haemophilia A with severe deficiency of factor VIII as measured by one-stage assay

21 January 2018

1 reference

Effects of the factor V G1691A mutation and the factor II G20210A variant on the clinical expression of severe hemophilia A in children--results of a multicenter studys

21 January 2018

1 reference

Contribution of natural anticoagulant and fibrinolytic factors in modulating the clinical severity of haemophilia patients.

21 January 2018

1 reference

Modifier genes in haemophilia: their expansion in the human genome

21 January 2018

1 reference

Mutation in blood coagulation factor V associated with resistance to activated protein C.

21 January 2018

1 reference

World distribution of factor V Leiden

21 January 2018

1 reference

Risk of venous thromboembolism and clinical manifestations in carriers of antithrombin, protein C, protein S deficiency, or activated protein C resistance: a multicenter collaborative family study

21 January 2018

1 reference

Inherited antithrombin deficiency: a review

21 January 2018

1 reference

Heterozygous antithrombin deficiency improves in vivo haemostasis in factor VIII-deficient mice.

21 January 2018

1 reference

Inhibition of antithrombin by protein SV-IV normalizes the coagulation of hemophilic blood

21 January 2018

1 reference

Thrombin generation and phenotypic correlation in haemophilia A.

21 January 2018

1 reference

Severe hemophilia with mild bleeding phenotype: molecular characterization and global coagulation profile

21 January 2018

1 reference

Interfering with disease: a progress report on siRNA-based therapeutics

21 January 2018

1 reference

21 January 2018

1 reference

Safety and efficacy of RNAi therapy for transthyretin amyloidosis

21 January 2018

1 reference

Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial

21 January 2018

1 reference

First-in-humans trial of an RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement

21 January 2018

1 reference

Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A.

21 January 2018

1 reference

A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia

21 January 2018

1 reference

Factor V Leiden improves in vivo hemostasis in murine hemophilia models

21 January 2018

1 reference

Phosphatidylinositol containing lipidic particles reduces immunogenicity and catabolism of factor VIII in hemophilia a mice

21 January 2018

1 reference

A sensitive venous bleeding model in haemophilia A mice: effects of two recombinant FVIII products (N8 and Advate(®)).

21 January 2018

1 reference

Prolonged effect of a new O-glycoPEGylated FVIII (N8-GP) in a murine saphenous vein bleeding model.

21 January 2018

1 reference

The heparin-binding exosite of factor IXa is a critical regulator of plasma thrombin generation and venous thrombosis

21 January 2018

1 reference

FVIIa as used pharmacologically is not TF dependent in hemophilia B mice

21 January 2018

1 reference

In vivo quantification of formulated and chemically modified small interfering RNA by heating-in-Triton quantitative reverse transcription polymerase chain reaction (HIT qRT-PCR).

21 January 2018

1 reference

A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state

21 January 2018

1 reference

Calibrated automated thrombin generation measurement in clotting plasma

21 January 2018

1 reference

Increased thrombin generation in a child with a combined factor IX and protein C deficiency.

21 January 2018

1 reference

12 December 2020

Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse

1 reference

12 December 2020

Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B.

1 reference

12 December 2020

Monoclonal antibodies to a synthetic fibrin-like peptide bind to human fibrin but not fibrinogen

1 reference

12 December 2020

Symptomatic onset of severe hemophilia A in childhood is dependent on the presence of prothrombotic risk factors

1 reference

12 December 2020

Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing

1 reference

12 December 2020

Effect of the factor V Leiden mutation on the clinical expression of severe hemophilia A.

1 reference

12 December 2020

Gene-gene and gene-environment interactions determine risk of thrombosis in families with inherited antithrombin deficiency

1 reference

12 December 2020

Risk of venous thromboembolism in relatives of symptomatic probands with thrombophilia: a systematic review

1 reference

12 December 2020