(Q45881781)

English

Multifactorial Gene Therapy Enhancing the Glutamate Uptake System and Reducing Oxidative Stress Delays Symptom Onset and Prolongs Survival in the SOD1-G93A ALS Mouse Model

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scholarly article

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/26691332

Multifactorial Gene Therapy Enhancing the Glutamate Uptake System and Reducing Oxidative Stress Delays Symptom Onset and Prolongs Survival in the SOD1-G93A ALS Mouse Model (English)

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/26691332

0 references

amyotrophic lateral sclerosis

1 reference

based on heuristic

inferred from title

author name string

Chen Benkler

1

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/26691332

Yael Barhum

2

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/26691332

Tali Ben-Zur

3

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/26691332

Daniel Offen

4

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/26691332

publication date

21 December 2015

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/26691332

Journal of Molecular Neuroscience

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/26691332

58

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/26691332

1

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/26691332

46-58

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/26691332

https://scigraph.springernature.com/pub.10.1007/s12031-015-0695-2

0 references

VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Oxidative stress in ALS: key role in motor neuron injury and therapeutic target

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Lessons from models of SOD1-linked familial ALS.

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Altered astrocytic response to activation in SOD1(G93A) mice and its implications on amyotrophic lateral sclerosis pathogenesis

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Chemical properties of antiepileptic drugs (AEDs).

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

ALS: a disease of motor neurons and their nonneuronal neighbors

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Astrocyte signaling and neurodegeneration: new insights into CNS disorders

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Astrocyte-specific overexpression of Nrf2 protects striatal neurons from mitochondrial complex II inhibition

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Oxidative stress, glutamate, and neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Amyotrophic lateral sclerosis: from current developments in the laboratory to clinical implications

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

A genome-wide association study of sporadic ALS in a homogenous Irish population.

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

A randomized, placebo-controlled trial of memantine for functional disability in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Development and characterisation of a glutamate-sensitive motor neurone cell line

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial.

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS).

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model.

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

ALS-linked Cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Molecular basis of human glutamate dehydrogenase regulation under changing energy demands

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Characterization and use of the NSC-34 cell line for study of neurotrophin receptor trafficking.

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Amyotrophic lateral sclerosis (ALS): three letters that change the people's life. For ever

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Astrocyte activation and reactive gliosis

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Regulation of human glutamate dehydrogenases: implications for glutamate, ammonia and energy metabolism in brain.

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

The seeds of neurodegeneration: prion-like spreading in ALS

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Current hypotheses for the underlying biology of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Human GLUD2 glutamate dehydrogenase is expressed in neural and testicular supporting cells

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS.

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Excitotoxicity and amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Crosstalk between astrocytes and motor neurons: what is the message?

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

The Nrf2-ARE cytoprotective pathway in astrocytes

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

The effect of mutant SOD1 dismutase activity on non-cell autonomous degeneration in familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Reduced oxidative damage in ALS by high-dose enteral melatonin treatment

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Neuronal intermediate filaments and ALS: a new look at an old question

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS12031-015-0695-2

21 January 2018

Amyotrophic lateral sclerosis: current understanding.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26691332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26691332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excitatory amino acid neurotransmission. Pathways for metabolism, storage and reuptake of glutamate in brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/26691332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II

1 reference

https://pubmed.ncbi.nlm.nih.gov/26691332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antioxidant treatment for amyotrophic lateral sclerosis or motor neuron disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26691332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/26691332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S12031-015-0695-2

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/26691332

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/26691332

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