(Q45926436)

17 December 2017

title

Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of Type 2 diabetes and obesity. (English)

1 reference

17 December 2017

0 references

0 references

Melanie Chin

1

1 reference

17 December 2017

Chun-Yue Ivy Lee

2

1 reference

17 December 2017

Jen-Chieh Chuang

3

1 reference

17 December 2017

Ron Bumeister

4

1 reference

17 December 2017

W Christian Wigley

5

1 reference

17 December 2017

Stephen T Sonis

6

1 reference

17 December 2017

Keith W Ward

7

1 reference

17 December 2017

Colin Meyer

8

1 reference

17 December 2017

publication date

17 April 2013

1 reference

17 December 2017

American Journal of Physiology - Renal Physiology

published in

1 reference

17 December 2017

volume

304

1 reference

17 December 2017

issue

12

1 reference

17 December 2017

page(s)

F1438-46

1 reference

17 December 2017

Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179.

cites work

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

Glutathione as a primary osmotic driving force in hepatic bile formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

Nrf2 activation enhances biliary excretion of sulfobromophthalein by inducing glutathione-S-transferase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

Diabetic downregulation of Nrf2 activity via ERK contributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

Nuclear factor erythroid 2-related factor 2 is a positive regulator of human bile salt export pump expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

Pomegranate flower ameliorates fatty liver in an animal model of type 2 diabetes and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

Nrf2-deficient female mice develop lupus-like autoimmune nephritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

Analogs of bardoxolone methyl worsen diabetic nephropathy in rats with additional adverse effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00387.2012

10.1152/AJPRENAL.00387.2012

21 January 2018

Identifiers

DOI

1 reference

17 December 2017

1 reference

17 December 2017