(Q34043950)

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Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease

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29 January 2020

Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease (English)

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29 January 2020

Huntington's disease

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based on heuristic

inferred from title

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29 January 2020

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M Flint Beal

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29 January 2020

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Cliona Stack

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29 January 2020

Daniel Ho

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29 January 2020

Elizabeth Wille

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29 January 2020

Noel Y Calingasan

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29 January 2020

Charlotte Williams

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29 January 2020

Michael Sporn

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29 January 2020

Magali Dumont

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29 January 2020

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23 March 2010

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29 January 2020

Free Radical Biology and Medicine

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29 January 2020

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29 January 2020

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29 January 2020

147-158

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29 January 2020

The triterpenoid CDDO limits inflammation in preclinical models of cystic fibrosis lung disease

1 reference

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5 July 2018

The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice

1 reference

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5 July 2018

Synthetic triterpenoids attenuate cytotoxic retinal injury: cross-talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN.

1 reference

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5 July 2018

The Nrf2-ARE cytoprotective pathway in astrocytes

1 reference

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5 July 2018

Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription.

1 reference

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5 July 2018

Impaired PGC-1alpha function in muscle in Huntington's disease.

1 reference

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5 July 2018

8-hydroxy-2' -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis

1 reference

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5 July 2018

Transcriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxin

1 reference

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5 July 2018

Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease

1 reference

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5 July 2018

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

1 reference

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5 July 2018

Nrf2 activators provide neuroprotection against 6-hydroxydopamine toxicity in rat organotypic nigrostriatal cocultures

1 reference

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5 July 2018

Evidence of oxidant damage in Huntington's disease: translational strategies using antioxidants

1 reference

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5 July 2018

The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration

1 reference

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5 July 2018

Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis

1 reference

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5 July 2018

Sulforaphane protects astrocytes against oxidative stress and delayed death caused by oxygen and glucose deprivation

1 reference

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5 July 2018

Mitochondrial DNA damage is a hallmark of chemically induced and the R6/2 transgenic model of Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

5 July 2018

Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila

1 reference

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5 July 2018

Synergistic neurotoxic effects of arsenic and dopamine in human dopaminergic neuroblastoma SH-SY5Y cells

1 reference

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5 July 2018

Increased oxidative damage and mitochondrial abnormalities in the peripheral blood of Huntington's disease patients

1 reference

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5 July 2018

Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.

1 reference

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5 July 2018

The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

5 July 2018

Nrf2-mediated protection against 6-hydroxydopamine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

5 July 2018

Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes.

1 reference

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5 July 2018

Expression of Nrf2 in neurodegenerative diseases

1 reference

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5 July 2018

Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

5 July 2018

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

5 July 2018

Oxidative damage in Huntington's disease pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

5 July 2018

DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

1 reference

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5 July 2018

Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications

1 reference

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5 July 2018

Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

5 July 2018

Excitotoxic brain damage involves early peroxynitrite formation in a model of Huntington's disease in rats: protective role of iron porphyrinate 5,10,15,20-tetrakis (4-sulfonatophenyl)porphyrinate iron (III).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

5 July 2018

The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

5 July 2018

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

1 reference

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5 July 2018

Potential neuroprotective effect of t-butylhydroquinone against neurotoxicity-induced by 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'-methyl-MPTP) in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

5 July 2018

Translating therapies for Huntington's disease from genetic animal models to clinical trials

1 reference

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5 July 2018

Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers.

1 reference

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5 July 2018

Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease

1 reference

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5 July 2018

Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

1 reference

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5 July 2018

Experimental therapeutics in transgenic mouse models of Huntington's disease

1 reference

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5 July 2018

Quinones and glutathione metabolism.

1 reference

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5 July 2018

Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis

1 reference

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5 July 2018

Secondary abnormalities of mitochondrial DNA associated with neurodegeneration

1 reference

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5 July 2018

Oxidative stress in Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

5 July 2018

Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

5 July 2018

Nitric oxide neurotoxicity

1 reference

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5 July 2018

Structure and function of glutathione S-transferases.

1 reference

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5 July 2018

Neuropathological classification of Huntington's disease

1 reference

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5 July 2018

Proliferative and degenerative changes in striatal spiny neurons in Huntington's disease: a combined study using the section-Golgi method and calbindin D28k immunocytochemistry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

5 July 2018

Proteomic and oxidative stress analysis in human brain samples of Huntington disease.

1 reference

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28 October 2018

The effects of vitamin supplementation on Drosophila life span under normoxia and under oxidative stress

1 reference

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28 October 2018

Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease.

1 reference

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28 October 2018

Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

28 October 2018

Microglial activation in presymptomatic Huntington's disease gene carriers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

28 October 2018

Transcription meets metabolism in neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

28 October 2018

Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration

1 reference

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28 October 2018

Microglial activation correlates with severity in Huntington disease: a clinical and PET study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

28 October 2018

Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

28 October 2018

Tryptophan metabolism and oxidative stress in patients with Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

28 October 2018

Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

28 October 2018

Additive neuroprotective effects of creatine and a cyclooxygenase 2 inhibitor against dopamine depletion in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

28 October 2018

Ascorbate treatment attenuates the Huntington behavioral phenotype in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

28 October 2018

A novel dicyanotriterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

28 October 2018

Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

28 October 2018

Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

28 October 2018

A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

28 October 2018

Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

28 October 2018

Early and progressive accumulation of reactive microglia in the Huntington disease brain

1 reference

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28 October 2018

Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages

1 reference

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28 October 2018

Striatal oxidative damage parallels the expression of a neurological phenotype in mice transgenic for the mutation of Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

28 October 2018

Oxidative damage to mitochondrial DNA in Huntington's disease parietal cortex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

28 October 2018

Cerebrospinal fluid F2-isoprostanes are elevated in Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

28 October 2018

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

1 reference

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28 October 2018

Regional specificity of brain atrophy in Huntington's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

28 October 2018

Energy metabolism defects in Huntington's disease and effects of coenzyme Q10.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

28 October 2018

In situ evidence for DNA fragmentation in Huntingtonʼs disease striatum and Alzheimerʼs disease temporal lobes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

28 October 2018

Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916021

28 October 2018

Identifiers

10.1016/J.FREERADBIOMED.2010.03.017

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20338236%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20338236%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20338236%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

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