(Q44674342)

English

Additive neuroprotective effects of creatine and a cyclooxygenase 2 inhibitor against dopamine depletion in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease.

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Europe PubMed Central

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21 December 2019

Additive neuroprotective effects of creatine and a cyclooxygenase 2 inhibitor against dopamine depletion in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease (English)

1 reference

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21 December 2019

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21 December 2019

5

object named as

M Flint Beal

1 reference

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21 December 2019

author name string

Gabrielle Gardian

2

1 reference

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21 December 2019

Noel Y Calingasan

3

1 reference

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21 December 2019

Lichuan Yang

4

1 reference

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21 December 2019

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publication date

1 January 2003

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21 December 2019

Journal of Molecular Neuroscience

1 reference

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21 December 2019

21

1 reference

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21 December 2019

3

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21 December 2019

191-198

1 reference

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21 December 2019

https://scigraph.springernature.com/pub.10.1385/jmn:21:3:191

0 references

Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of creatine kinase in inhibition of mitochondrial permeability transition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenases: structural, cellular, and molecular biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FcepsilonRII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase-2 induction in cerebral cortex: an intracellular response to synaptic excitation

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of repeated systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mice on interleukin-1beta and nerve growth factor in the striatum.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the cyclooxygenase isoenzymes COX-1 and COX-2 provide neuroprotection in the MPTP-mouse model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficient three-drug cocktail for disease induced by mutant superoxide dismutase

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inflammatory reaction following 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine intoxication in mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of cyclooxygenase (COX)-2 but not COX-1 gene expression in apoptotic cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphisms in the interleukin-1 alpha and beta genes and the risk for Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Creatine and cyclocreatine attenuate MPTP neurotoxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons In vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic mice expressing a dominant negative mutant interleukin-1beta converting enzyme show resistance to MPTP neurotoxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced creatine kinase activity in transgenic amyotrophic lateral sclerosis mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial and astrocytic involvement in a murine model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of cyclooxygenase-2 in the rat brain after a mild episode of focal ischemia without tissue inflammation or neural cell damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphocreatine-dependent Glutamate Uptake by Synaptic Vesicles

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental models of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the characterization of the inhibitory mechanism of 4'-alkylated 1-methyl-4-phenylpyridinium and phenylpyridine analogues in mitochondria and electron transport particles

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 levels in cerebrospinal fluid inversely correlate to severity of Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of interleukin-1 beta polymorphisms with idiopathic Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 beta induces prostaglandin G/H synthase-2 (cyclooxygenase-2) in primary murine astrocyte cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of mitochondrial biogenesis in skeletal muscle by CaMK

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha-Phenyl-tert-butyl-nitrone reduces cortical infarct and edema in rats subjected to focal ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The coxibs, selective inhibitors of cyclooxygenase-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of the NADPH oxidase in activated rat microglia removes nitric oxide but induces peroxynitrite production

1 reference

https://pubmed.ncbi.nlm.nih.gov/14645986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1385/JMN:21:3:191

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14645986%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14645986%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

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