(Q45927229)

17 December 2017

title

Regulation of insulin gene expression by cytokines and cell-cell interactions in mouse medullary thymic epithelial cells. (English)

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17 December 2017

author

Constantin Polychronakos

series ordinal

2

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17 December 2017

author name string

D Levi

series ordinal

1

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17 December 2017

publication date

16 July 2009

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17 December 2017

published in

Diabetologia

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17 December 2017

volume

52

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17 December 2017

issue

10

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17 December 2017

page(s)

2151-2158

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17 December 2017

https://scigraph.springernature.com/pub.10.1007/s00125-009-1448-y

exact match

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cites work

Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)

1 reference

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https://api.crossref.org/works/10.1007%2FS00125-009-1448-Y

Features of medullary thymic epithelium implicate postnatal development in maintaining epithelial heterogeneity and tissue-restricted antigen expression.

21 January 2018

1 reference

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https://api.crossref.org/works/10.1007%2FS00125-009-1448-Y

Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice

21 January 2018

1 reference

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https://api.crossref.org/works/10.1007%2FS00125-009-1448-Y

Intrathymic expression of genes involved in organ specific autoimmune disease

21 January 2018

1 reference

12 December 2020

Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism

1 reference

12 December 2020

Extracellular matrix components of the mouse thymus microenvironment. V. Interferon-gamma modulates thymic epithelial cell/thymocyte interactions via extracellular matrix ligands and receptors

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Autoimmune polyendocrinopathy--candidosis--ectodermal dystrophy (APECED): autosomal recessive inheritance

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12 December 2020

Imprinted and Genotype-specific Expression of Genes at theIDDM2Locus in Pancreas and Leucocytes

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12 December 2020

Tolerance to proinsulin-2 is due to radioresistant thymic cells

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12 December 2020

Positional cloning of the APECED gene

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12 December 2020

CD4 T cell tolerance to nuclear proteins induced by medullary thymic epithelium

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12 December 2020

Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

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12 December 2020

Cytokines in the thymus: production and biological effects

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12 December 2020

Lymphotoxin pathway directs thymic Aire expression

1 reference

12 December 2020

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

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12 December 2020

Tolerance induction by thymic medullary epithelium

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12 December 2020

CD4 T cell tolerance to human C-reactive protein, an inducible serum protein, is mediated by medullary thymic epithelium

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12 December 2020

Modifier loci condition autoimmunity provoked by Aire deficiency

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12 December 2020

Triggering and amplifying pathways of regulation of insulin secretion by glucose

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12 December 2020

TNF and Fas-induced apoptosis during negative selection in thymic nurse cells

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12 December 2020

Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue-specific protein

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12 December 2020

Regulation of the insulin gene by glucose and fatty acids

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12 December 2020

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus

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12 December 2020

Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma

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12 December 2020

The new Medicare Part D prescription drug benefit: an estimation of its effect on prescription drug costs in a Medicare population with atrial fibrillation

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12 December 2020

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

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12 December 2020

Expression of preproinsulin-2 gene shapes the immune response to preproinsulin in normal mice

1 reference

12 December 2020

Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes

1 reference

12 December 2020

Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters

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12 December 2020

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

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12 December 2020

The thymus as an inductive site for T lymphopoiesis

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12 December 2020

Comparison of thymocyte development and cytokine production in CD7-deficient, CD28-deficient and CD7/CD28 double-deficient mice

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12 December 2020

The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

1 reference

12 December 2020

Projection of an immunological self shadow within the thymus by the aire protein

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12 December 2020

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

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12 December 2020

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.

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12 December 2020

An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus

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12 December 2020

Medullary thymic epithelial cells induce tolerance to intracellular proteins.

1 reference

12 December 2020

Isolation and characterization of proinsulin-producing medullary thymic epithelial cell clones

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12 December 2020

An acetylcholine receptor alpha subunit promoter confers intrathymic expression in transgenic mice. Implications for tolerance of a transgenic self-antigen and for autoreactivity in myasthenia gravis

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12 December 2020

Insulin as an autoantigen in NOD/human diabetes

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12 December 2020

Tolerance and auto-immunity: 50 years after Burnet

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12 December 2020

The shaping of the brain-specific T lymphocyte repertoire in the thymus.

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12 December 2020

10.1007/S00125-009-1448-Y

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DOI

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17 December 2017

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17 December 2017