(Q45952950)

English

Extracellular signal-regulated kinase 2 (ERK-2) mediated phosphorylation regulates nucleo-cytoplasmic shuttling and cell growth control of Ras-associated tumor suppressor protein, RASSF2.

scientific article published on 23 June 2009

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scholarly article

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Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/19555684

Extracellular signal-regulated kinase 2 (ERK-2) mediated phosphorylation regulates nucleo-cytoplasmic shuttling and cell growth control of Ras-associated tumor suppressor protein, RASSF2. (English)

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Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/19555684

phosphorylation

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Gita Kumari

1

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Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/19555684

S Mahalingam

2

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18 December 2017

http://europepmc.org/abstract/MED/19555684

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23 June 2009

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http://europepmc.org/abstract/MED/19555684

Experimental Cell Research

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http://europepmc.org/abstract/MED/19555684

315

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18 December 2017

http://europepmc.org/abstract/MED/19555684

2775-2790

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18 December 2017

http://europepmc.org/abstract/MED/19555684

16

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Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/19555684

RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor

1 reference

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RASSF4/AD037 is a potential ras effector/tumor suppressor of the RASSF family.

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Role of the Ras-association domain family 1 tumor suppressor gene in human cancers

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The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death

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The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex

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Tumor suppressor RASSF1A is a microtubule-binding protein that stabilizes microtubules and induces G2/M arrest

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Epigenetic inactivation of the candidate 3p21.3 suppressor gene BLU in human cancers.

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RASSF2, a potential tumour suppressor, is silenced by CpG island hypermethylation in gastric cancer

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NORE1A, a homologue of RASSF1A tumour suppressor gene is inactivated in human cancers

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Aberrant promoter methylation and silencing of the RASSF1A gene in pediatric tumors and cell lines

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Nucleocytoplasmic shuttling of p130/RBL2: novel regulatory mechanism.

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Regulation of tumor suppressors by nuclear-cytoplasmic shuttling

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The importance of p53 location: nuclear or cytoplasmic zip code?

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Cdc25A localisation and shuttling: characterisation of sequences mediating nuclear export and import.

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Combinatorial control of cyclin B1 nuclear trafficking through phosphorylation at multiple sites

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Regulation of p53 function

1 reference

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Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding.

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Phosphorylation by the beta-catenin/MAPK complex promotes 14-3-3-mediated nuclear export of TCF/POP-1 in signal-responsive cells in C. elegans

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Transport of proteins and RNAs in and out of the nucleus

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Nucleocytoplasmic transport

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Nuclear targeting sequences--a consensus?

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Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region

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CRM1-mediated nuclear export: to the pore and beyond.

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Use of a hybrid vaccinia virus-T7 RNA polymerase system for expression of target genes

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Functional analysis of the simian immunodeficiency virus Vpx protein: identification of packaging determinants and a novel nuclear targeting domain.

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Nuclear transport of Ras-associated tumor suppressor proteins: different transport receptor binding specificities for arginine-rich nuclear targeting signals.

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Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

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A novel nuclear export signal in Smad1 is essential for its signaling activity

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Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export

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Regulation of the accumulation and function of p53 by phosphorylation of two residues within the domain that binds to Mdm2.

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Phosphorylation by cdc2-CyclinB1 kinase releases cytoplasmic dynein from membranes

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The Activation of the c-Jun N-terminal Kinase and p38 Mitogen-activated Protein Kinase Signaling Pathways Protects HeLa Cells from Apoptosis Following Photodynamic Therapy with Hypericin

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Making ribosomes

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Conventional and nonconventional roles of the nucleolus

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The nucleolus: at the stem of immortality

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Does the ribosome translate cancer?

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Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus.

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DNA damage disrupts the p14ARF-B23(nucleophosmin) interaction and triggers a transient subnuclear redistribution of p14ARF.

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Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability

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Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels

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p34cdc2-mediated phosphorylation at T124 inhibits nuclear import of SV-40 T antigen proteins

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Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein

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CDK phosphorylation of a novel NLS-NES module distributed between two subunits of the Mcm2-7 complex prevents chromosomal rereplication

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Identifiers

10.1016/J.YEXCR.2009.06.013

1 reference

Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/19555684

1 reference

Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/19555684

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