(Q45963960)

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First in human trial of a type I positive allosteric modulator of alpha7-nicotinic acetylcholine receptors: Pharmacokinetics, safety, and evidence for neurocognitive effect of AVL-3288.

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Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/28196430

First in human trial of a type I positive allosteric modulator of alpha7-nicotinic acetylcholine receptors: Pharmacokinetics, safety, and evidence for neurocognitive effect of AVL-3288. (English)

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Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/28196430

pharmacokinetics

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Ann Olincy

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Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/28196430

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Kelvin W Gee

1

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Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/28196430

Richard Kanner

3

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Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/28196430

Lynn Johnson

4

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Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/28196430

Derk Hogenkamp

5

1 reference

Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/28196430

Josette Harris

6

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Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/28196430

Minhtam Tran

7

1 reference

Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/28196430

Stephen A Edmonds

8

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Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/28196430

William Sauer

9

1 reference

Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/28196430

Ryan Yoshimura

10

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Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/28196430

Timothy Johnstone

11

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Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/28196430

Robert Freedman

12

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18 December 2017

http://europepmc.org/abstract/MED/28196430

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1 February 2017

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Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/28196430

Journal of Psychopharmacology

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18 December 2017

http://europepmc.org/abstract/MED/28196430

31

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18 December 2017

http://europepmc.org/abstract/MED/28196430

4

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18 December 2017

http://europepmc.org/abstract/MED/28196430

434-441

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Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/28196430

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Randomized, Double-Blind, Placebo-Controlled Study of Encenicline, an α7 Nicotinic Acetylcholine Receptor Agonist, as a Treatment for Cognitive Impairment in Schizophrenia

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Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators

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Positive allosteric modulators of alpha 7 nicotinic acetylcholine receptors reverse ketamine-induced schizophrenia-like deficits in rats.

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Positive allosteric modulation of alpha 7 nicotinic acetylcholine receptors enhances recognition memory and cognitive flexibility in rats

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Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia

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Desensitization of neuronal nicotinic receptors

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Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats

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Inhibition of human cytochrome P450 2E1 by nicotine, cotinine, and aqueous cigarette tar extract in vitro

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Allosteric alpha-7 nicotinic receptor modulation and P50 sensory gating in schizophrenia: a proof-of-mechanism study.

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Identifiers

10.1177/0269881117691590

1 reference

Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/28196430

1 reference

Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/28196430

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