(Q46026257)

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Validation of a voltage-sensitive dye (di-4-ANEPPS)-based method for assessing drug-induced delayed repolarisation in beagle dog left ventricular midmyocardial myocytes.

scientific article published on 4 May 2009

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27 January 2020

Validation of a voltage-sensitive dye (di-4-ANEPPS)-based method for assessing drug-induced delayed repolarisation in beagle dog left ventricular midmyocardial myocytes (English)

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27 January 2020

voltage-sensitive dye

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based on heuristic

inferred from title

3

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27 January 2020

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Matthew E L Hardy

1

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27 January 2020

Chris E Pollard

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27 January 2020

Matthew Bridgland-Taylor

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27 January 2020

Ann J Woods

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27 January 2020

Jean-Pierre Valentin

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27 January 2020

Najah Abi-Gerges

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27 January 2020

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4 May 2009

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27 January 2020

Journal of Pharmacological and Toxicological Methods

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27 January 2020

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27 January 2020

1

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27 January 2020

94-106

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27 January 2020

Evidence for gender differences in electrophysiological properties of canine Purkinje fibres.

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Heterogeneity and cardiac arrhythmias: an overview.

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Comparison of the cellular electrophysiological characteristics of canine left ventricular epicardium, M cells, endocardium and Purkinje fibres.

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Points to consider emerging from a mini-workshop on cardiac safety: assessing torsades de pointes liability.

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Interaction of different potassium channels in cardiac repolarization in dog ventricular preparations: role of repolarization reserve

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Optimisation and validation of a medium-throughput electrophysiology-based hERG assay using IonWorks HT.

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Prediction of the risk of Torsade de Pointes using the model of isolated canine Purkinje fibres

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Cytosolic Ca2+ triggers early afterdepolarizations and Torsade de Pointes in rabbit hearts with type 2 long QT syndrome

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Comparative pharmacology of guinea pig cardiac myocyte and cloned hERG (I(Kr)) channel.

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Antiarrhythmic effect of IKr activation in a cellular model of LQT3.

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The canine Purkinje fiber: an in vitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis

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Sensitivity and specificity of isolated perfused guinea pig heart to test for drug-induced lengthening of QTc.

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ILSI-HESI cardiovascular safety subcommittee initiative: evaluation of three non-clinical models of QT prolongation.

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Can optical recordings of membrane potential be used to screen for drug-induced action potential prolongation in single cardiac myocytes?

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Optimisation and validation of a medium-throughput electrophysiology-based hNav1.5 assay using IonWorks.

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Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic

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Blinded test in isolated female rabbit heart reliably identifies action potential duration prolongation and proarrhythmic drugs: importance of triangulation, reverse use dependence, and instability

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7 January 2021

Evaluation of the guinea pig monophasic action potential (MAP) assay in predicting drug-induced delay of ventricular repolarisation using 12 clinically documented drugs

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Alfuzosin delays cardiac repolarization by a novel mechanism

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A rabbit Langendorff heart proarrhythmia model: predictive value for clinical identification of Torsades de Pointes

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Species plays an important role in drug-induced prolongation of action potential duration and early afterdepolarizations in isolated Purkinje fibers

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Choice of cardiac tissue in vitro plays an important role in assessing the risk of drug-induced cardiac arrhythmias in human: beyond QT prolongation

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7 January 2021

Comparison of the in vitro electrophysiologic and proarrhythmic effects of amiodarone and sotalol in a rabbit model of acute atrioventricular block

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Developmental changes in IKr and IKs contribute to age-related expression of dofetilide effects on repolarization and proarrhythmia

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7 January 2021

Blocking characteristics of hERG, hNav1.5, and hKvLQT1/hminK after administration of the novel anti-arrhythmic compound AZD7009

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7 January 2021

Blocking characteristics of hKv1.5 and hKv4.3/hKChIP2.2 after administration of the novel antiarrhythmic compound AZD7009.

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Di-4-ANEPPS causes photodynamic damage to isolated cardiomyocytes

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Ionworks HT: a new high-throughput electrophysiology measurement platform.

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Paradoxical loss of excitation with high intensity pulses during electric field stimulation of single cardiac cells

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Drug-induced afterdepolarizations and triggered activity occur in a discrete subpopulation of ventricular muscle cells (M cells) in the canine heart: quinidine and digitalis

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Antagonism by ranolazine of the pro-arrhythmic effects of increasing late INa in guinea pig ventricular myocytes

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Asymmetrical distribution of ion channels in canine and human left-ventricular wall: epicardium versus midmyocardium

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Comparison of guinea-pig ventricular myocytes and dog Purkinje fibres for in vitro assessment of drug-induced delayed repolarization

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1 reference

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10.1016/J.VASCN.2009.03.005

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19414070%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19414070%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

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