(Q51104877)

29 March 2018

title

Points to consider emerging from a mini-workshop on cardiac safety: assessing torsades de pointes liability. (English)

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29 March 2018

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Alan Bass

1

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29 March 2018

Jean-Pierre Valentin

series ordinal

2

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29 March 2018

Anthony A Fossa

series ordinal

3

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29 March 2018

Paul G A Volders

series ordinal

4

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29 March 2018

publication date

24 May 2007

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29 March 2018

Journal of Pharmacological and Toxicological Methods

published in

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29 March 2018

volume

56

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29 March 2018

issue

2

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29 March 2018

page(s)

91-94

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29 March 2018

Pentamidine reduces hERG expression to prolong the QT interval

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Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome

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Drug-induced torsades de pointes and implications for drug development.

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Mechanisms of arsenic-induced prolongation of cardiac repolarization

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The relationship of clinical QT prolongation to outcome in the conscious dog using a beat-to-beat QT-RR interval assessment

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QT prolongation modifies dynamic restitution and hysteresis of the beat-to-beat QT-TQ interval relationship during normal sinus rhythm under varying states of repolarization

7 January 2021

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Dynamic beat-to-beat modeling of the QT-RR interval relationship: analysis of QT prolongation during alterations of autonomic state versus human ether a-go-go-related gene inhibition

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ILSI-HESI cardiovascular safety subcommittee initiative: evaluation of three non-clinical models of QT prolongation.

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Pentamidine-induced long QT syndrome and block of hERG trafficking

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A rabbit Langendorff heart proarrhythmia model: predictive value for clinical identification of Torsades de Pointes

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Nonclinical proarrhythmia models: predicting Torsades de Pointes

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Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

7 January 2021

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QT PRODACT: inter-facility variability in electrocardiographic and hemodynamic parameters in conscious dogs and monkeys

7 January 2021

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Ranolazine: ion-channel-blocking actions and in vivo electrophysiological effects

7 January 2021

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7 January 2021

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Temporal patterns of electrical remodeling in canine ventricular hypertrophy: focus on IKs downregulation and blunted beta-adrenergic activation.

7 January 2021

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Non-cardiac QTc-prolonging drugs and the risk of sudden cardiac death

7 January 2021

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Assessing the proarrhythmic potential of drugs: current status of models and surrogate parameters of torsades de pointes arrhythmias.

7 January 2021

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Determination of myocardium to plasma concentration ratios of five antipsychotic drugs: comparison with their ability to induce arrhythmia and sudden death in clinical practice.

7 January 2021

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10.1016/J.VASCN.2007.05.001

7 January 2021

Identifiers

DOI

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29 March 2018

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29 March 2018