(Q46034429)

18 December 2017

title

Safety, pharmacokinetics, and pharmacodynamics of single doses of LXR-623, a novel liver X-receptor agonist, in healthy participants. (English)

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18 December 2017

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Arie Katz

1

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18 December 2017

Chandrasekhar Udata

2

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18 December 2017

Elyssa Ott

3

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18 December 2017

Lisa Hickey

4

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18 December 2017

Michael E Burczynski

5

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18 December 2017

Peter Burghart

6

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18 December 2017

Ole Vesterqvist

7

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18 December 2017

Xu Meng

8

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18 December 2017

publication date

27 April 2009

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18 December 2017

The Journal of Clinical Pharmacology

published in

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18 December 2017

volume

49

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18 December 2017

issue

6

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18 December 2017

page(s)

643-649

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18 December 2017

Role of LXRs in control of lipogenesis

cites work

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

Synthetic LXR agonists increase LDL in CETP species

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

Understanding hyperlipidemia and atherosclerosis: lessons from genetically modified apoe and ldlr mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

Role of LXR and ABCA1 in the pathogenesis of Alzheimer's disease - implications for a new therapeutic approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

Liver X receptor-mediated gene regulation and cholesterol homeostasis in brain: relevance to Alzheimer's disease therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

Cholesterol efflux as a critical component of Alzheimer's disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

Expression of Liver X Receptor Target Genes Decreases Cellular Amyloid β Peptide Secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

Regulation of Cholesterol Homeostasis by the Liver X Receptors in the Central Nervous System

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270009335768

21 January 2018

Identifiers

DOI

10.1177/0091270009335768

1 reference

18 December 2017

PubMed ID

19398602

1 reference

18 December 2017