(Q46040247)

18 December 2017

title

Triggering ubiquitination of a CDK inhibitor at origins of DNA replication. (English)

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18 December 2017

main subject

protein ubiquitination

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L Furstenthal

1

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18 December 2017

C Swanson

2

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18 December 2017

B K Kaiser

3

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18 December 2017

A G Eldridge

4

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18 December 2017

P K Jackson

5

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18 December 2017

publication date

1 August 2001

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18 December 2017

published in

Nature Cell Biology

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18 December 2017

volume

3

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18 December 2017

page(s)

715-722

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18 December 2017

issue

8

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18 December 2017

https://scigraph.springernature.com/pub.10.1038/35087026

exact match

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cites work

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SCF and Cullin/Ring H2-based ubiquitin ligases

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

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Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

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Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

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p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

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Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins

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7 January 2021

Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination

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7 January 2021

A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p

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7 January 2021

Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase

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Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle

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A role for cyclin E/Cdk2 in the timing of the midblastula transition in Xenopus embryos

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p27Xic1, a Cdk inhibitor, promotes the determination of glial cells in Xenopus retina

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The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators

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7 January 2021

A human protein related to yeast Cdc6p

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7 January 2021

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Geminin, an inhibitor of DNA replication, is degraded during mitosis

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7 January 2021

Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination

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7 January 2021

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7 January 2021

Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A.

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7 January 2021

Evidence for sequential action of cdc7 and cdk2 protein kinases during initiation of DNA replication in Xenopus egg extracts.

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7 January 2021

Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk.

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7 January 2021

The Cdc42p effector Gic2p is targeted for ubiquitin-dependent degradation by the SCFGrr1 complex

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7 January 2021

Cyclin-dependent kinase control of centrosome duplication

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7 January 2021

Cyclin synthesis drives the early embryonic cell cycle

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7 January 2021

Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

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7 January 2021

Early events in DNA replication require cyclin E and are blocked by p21CIP1.

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7 January 2021

Identifiers

DOI

10.1038/35087026

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18 December 2017

PubMed ID

11483956

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18 December 2017