(Q46053556)

19 December 2017

title

Essential roles of the kappa light chain intronic enhancer and 3' enhancer in kappa rearrangement and demethylation (English)

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19 December 2017

author name string

Matthew Inlay

1

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19 December 2017

Frederick W Alt

2

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19 December 2017

David Baltimore

3

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19 December 2017

Yang Xu

4

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19 December 2017

language of work or name

English

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publication date

22 April 2002

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19 December 2017

published in

Nature Immunology

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19 December 2017

volume

3

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19 December 2017

issue

5

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19 December 2017

page(s)

463-468

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19 December 2017

Mechanism and developmental program of immunoglobulin gene rearrangement in mammals

cites work

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7 January 2021

Development of the primary antibody repertoire

1 reference

7 January 2021

Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements

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7 January 2021

Immunoglobulin gene transcription is activated by downstream sequence elements

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7 January 2021

Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites

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7 January 2021

Deletion of the Ig kappa light chain intronic enhancer/matrix attachment region impairs but does not abolish V kappa J kappa rearrangement

1 reference

7 January 2021

The Ig(kappa) enhancer influences the ratio of Ig(kappa) versus Ig(lambda) B lymphocytes

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7 January 2021

B cell-specific demethylation: a novel role for the intronic kappa chain enhancer sequence

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7 January 2021

Kappa chain monoallelic demethylation and the establishment of allelic exclusion

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7 January 2021

V(D)J recombination is not activated by demethylation of the kappa locus

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7 January 2021

A role for nuclear NF-kappaB in B-cell-specific demethylation of the Igkappa locus

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7 January 2021

Frequencies of multiple IgL chain gene rearrangements in single normal or kappaL chain-deficient B lineage cells

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7 January 2021

A complex translocation at the murine kappa light-chain locus

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7 January 2021

Lack of feedback inhibition of V kappa gene rearrangement by productively rearranged alleles

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7 January 2021

Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus

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7 January 2021

Receptor editing in self-reactive bone marrow B cells

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7 January 2021

B lymphocytes may escape tolerance by revising their antigen receptors

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7 January 2021

BCR ligation induces receptor editing in IgM+IgD- bone marrow B cells in vitro

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7 January 2021

Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection.

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7 January 2021

Regulation of immunoglobulin light chain isotype expression.

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7 January 2021

Rearrangement-enhancing element upstream of the mouse immunoglobulin kappa chain J cluster.

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7 January 2021

E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells

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7 January 2021

Dual roles of ATM in the cellular response to radiation and in cell growth control.

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7 January 2021

High sensitivity mapping of methylated cytosines

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7 January 2021

Identifiers

DOI

10.1038/NI790

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19 December 2017

PubMed ID

11967540

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19 December 2017