(Q46058982)

English

Activation of Src kinase by protein-tyrosine phosphatase-PEST in osteoclasts: comparative analysis of the effects of bisphosphonate and protein-tyrosine phosphatase inhibitor on Src activation in vitro

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scholarly article

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19350555

Activation of Src kinase by protein-tyrosine phosphatase-PEST in osteoclasts: comparative analysis of the effects of bisphosphonate and protein-tyrosine phosphatase inhibitor on Src activation in vitro (English)

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19350555

author name string

Meenakshi A Chellaiah

1

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19350555

Michael D Schaller

2

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19350555

publication date

1 August 2009

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19350555

Journal of Cellular Physiology

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19350555

220

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19350555

2

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19350555

382-393

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19350555

PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Focal complex formation in adult cardiomyocytes is accompanied by the activation of beta3 integrin and c-Src

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Src kinase regulation by phosphorylation and dephosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteopontin deficiency produces osteoclast dysfunction due to reduced CD44 surface expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of a structurally unique osteoclastic protein-tyrosine phosphatase is driven by an alternative intronic, cell type-specific promoter

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New Insights Into the Molecular Mechanisms of Action of Bisphosphonates

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WASp deficiency in mice results in failure to form osteoclast sealing zones and defects in bone resorption

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dramatic inhibition of osteoclast sealing ring formation and bone resorption in vitro by a WASP-peptide containing pTyr294 amino acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cortactin regulates cell migration through activation of N-WASP

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The small GTP-binding protein, rho p21, is involved in bone resorption by regulating cytoskeletal organization in osteoclasts.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathophysiology of bone metastases: how this knowledge may lead to therapeutic intervention.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a filamin docking site on PTP-PEST.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of c-Src kinase in the regulation of osteoclast function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An osteoclastic protein-tyrosine phosphatase is a potential positive regulator of the c-Src protein-tyrosine kinase activity: a mediator of osteoclast activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Src kinase associates with a member of a distinct subfamily of protein-tyrosine phosphatases containing an ezrin-like domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alendronate inhibits lysophosphatidic acid-induced migration of human ovarian cancer cells by attenuating the activation of rho.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of fibroblast motility by the protein tyrosine phosphatase PTP-PEST

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine phosphatase-epsilon activates Src and supports the transformed phenotype of Neu-induced mammary tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-Src is required for stimulation of gelsolin-associated phosphatidylinositol 3-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antisense oligodeoxynucleotide inhibition of a swelling-activated cation channel in osteoblast-like osteosarcoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteopontin stimulates gelsolin-associated phosphoinositide levels and phosphatidylinositol triphosphate-hydroxyl kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular and molecular mechanisms of action of bisphosphonates

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A possible mechanism of the specific action of bisphosphonates on osteoclasts: tiludronate preferentially affects polarized osteoclasts having ruffled borders

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of a Wiscott-Aldrich syndrome protein-associated signal complex is critical in osteoclast bone resorption

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine Phosphatase Epsilon Is a Positive Regulator of Osteoclast Function in Vitro and In Vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein tyrosine phosphatases in osteoclast differentiation, adhesion, and bone resorption

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTP-PEST: a protein tyrosine phosphatase regulated by serine phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of MMP-9 (gelatinase B) in activated human monocyte/macrophages by two different types of bisphosphonates

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of dynamin in the assembly and function of podosomes and invadopodia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Src SH2 selective binding compound inhibits osteoclast-mediated resorption.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of podosomes by integrin alphavbeta3 and Rho GTPase-facilitated phosphoinositide signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Src phosphorylation of cortactin enhances actin assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the activity of SRC and Abl tyrosine protein kinases by the binding of the Wiskott-Aldrich syndrome protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho-A is critical for osteoclast podosome organization, motility, and bone resorption

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms of bone resorption: therapeutic implications.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simplified system for generating recombinant adenoviruses

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combination of gene targeting and substrate trapping to identify substrates of protein tyrosine phosphatases using PTP-PEST as a model

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteoclasts express high levels of p60c-src, preferentially on ruffled border membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein tyrosine phosphatases in osteoclasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cortactin has an essential and specific role in osteoclast actin assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bone cell phosphotyrosine phosphatase: characterization and regulation by calcitropic hormones

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alendronate inhibition of protein-tyrosine-phosphatase-meg1

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Actin Ring Formation by Rho GTPases in Osteoclasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of cortactin and N-WASp with Arp2/3 complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Actin polymerization modulates CD44 surface expression, MMP-9 activation, and osteoclast function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1

1 reference

https://pubmed.ncbi.nlm.nih.gov/19350555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/JCP.21777

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19350555

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19350555

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