(Q46072984)

19 December 2017

title

CDK phosphorylation inhibits the DNA-binding and ATP-hydrolysis activities of the Drosophila origin recognition complex (English)

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19 December 2017

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4

Michael R Botchan

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19 December 2017

author name string

Dirk Remus

series ordinal

1

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19 December 2017

Marco Blanchette

series ordinal

2

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19 December 2017

Donald C Rio

series ordinal

3

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19 December 2017

language of work or name

English

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publication date

27 September 2005

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19 December 2017

Journal of Biological Chemistry

published in

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19 December 2017

volume

280

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19 December 2017

page(s)

39740-39751

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19 December 2017

issue

48

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19 December 2017

DNA replication in eukaryotic cells

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21 January 2018

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Construction by gene targeting in human cells of a "conditional' CDC2 mutant that rereplicates its DNA.

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Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis.

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A role for Cdk2 kinase in negatively regulating DNA replication during S phase of the cell cycle

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Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms

21 January 2018

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Unphosphorylatable mutants of Cdc6 disrupt its nuclear export but still support DNA replication once per cell cycle

21 January 2018

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Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding

21 January 2018

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Drosophila double-parked is sufficient to induce re-replication during development and is regulated by cyclin E/CDK2.

21 January 2018

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Cell cycle dependent regulation of the origin recognition complex

21 January 2018

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Interaction of the S-phase cyclin Clb5 with an "RXL" docking sequence in the initiator protein Orc6 provides an origin-localized replication control switch.

21 January 2018

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Control of DNA rereplication via Cdc2 phosphorylation sites in the origin recognition complex

21 January 2018

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Two steps in the assembly of complexes at yeast replication origins in vivo

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Interaction of Xenopus Cdc2 x cyclin A1 with the origin recognition complex.

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The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p

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Identification of a novel 81-kDa component of the Xenopus origin recognition complex

21 January 2018

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Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2

21 January 2018

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Cyclin A-dependent kinase activity affects chromatin binding of ORC, Cdc6, and MCM in egg extracts of Xenopus laevis.

21 January 2018

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Cell cycle modulation of protein-DNA interactions at a human replication origin

21 January 2018

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Localization of proteins bound to a replication origin of human DNA along the cell cycle

21 January 2018

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Degradation of origin recognition complex large subunit by the anaphase-promoting complex in Drosophila

21 January 2018

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Chinese hamster ORC subunits dynamically associate with chromatin throughout the cell-cycle

21 January 2018

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Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex

21 January 2018

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Functional analysis of mutant and wild-type Drosophila origin recognition complex

21 January 2018

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DNA topology, not DNA sequence, is a critical determinant for Drosophila ORC-DNA binding

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Assembly of functionally active Drosophila origin recognition complex from recombinant proteins

21 January 2018

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Structure and function of Cdc6/Cdc18: implications for origin recognition and checkpoint control

21 January 2018

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The BAH (bromo-adjacent homology) domain: a link between DNA methylation, replication and transcriptional regulation

21 January 2018

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Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex

21 January 2018

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Targeted proteomic study of the cyclin-Cdk module.

21 January 2018

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Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates.

21 January 2018

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Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

21 January 2018

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The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases

21 January 2018

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Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

21 January 2018

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Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2').

21 January 2018

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Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes

21 January 2018

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latheo, a Drosophila gene involved in learning, regulates functional synaptic plasticity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M508515200

latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508515200

A cytokinetic function of Drosophila ORC6 protein resides in a domain distinct from its replication activity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M508515200

ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication

21 January 2018

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Continuous Cyclin E expression inhibits progression through endoreduplication cycles in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508515200

Fluctuations in cyclin E levels are required for multiple rounds of endocycle S phase in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508515200

Cdks and the Drosophila cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508515200

Cell cycle control of chorion gene amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508515200

On target with a new mechanism for the regulation of protein phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508515200

Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508515200

Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508515200

E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508515200

CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508515200

CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508515200

Protein kinase CK2: a challenge to canons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508515200

One-thousand-and-one substrates of protein kinase CK2?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508515200

21 January 2018

Identifiers

DOI

10.1074/JBC.M508515200

1 reference

19 December 2017

PubMed ID

16188887

1 reference

19 December 2017