(Q46084697)

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Intracerebroventricular administration of N-acetylaspartic acid impairs antioxidant defenses and promotes protein oxidation in cerebral cortex of rats.

scientific article published on 18 March 2009

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Europe PubMed Central

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23 January 2020

Intracerebroventricular administration of N-acetylaspartic acid impairs antioxidant defenses and promotes protein oxidation in cerebral cortex of rats (English)

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23 January 2020

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Carolina Didonet Pederzolli

1

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23 January 2020

Francieli Juliana Rockenbach

2

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23 January 2020

Fernanda Rech Zanin

3

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23 January 2020

Nicoli Taiana Henn

4

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23 January 2020

Eline Coan Romagna

5

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23 January 2020

Angela M Sgaravatti

6

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23 January 2020

Clóvis M D Wannmacher

8

1 reference

Europe PubMed Central

PubMed publication ID

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23 January 2020

Angela de Mattos Dutra

10

1 reference

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23 January 2020

Carlos S Dutra-Filho

11

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23 January 2020

publication date

18 March 2009

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23 January 2020

number of pages

16

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inferred from page(s)

Metabolic Brain Disease

1 reference

Europe PubMed Central

PubMed publication ID

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23 January 2020

24

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23 January 2020

2

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23 January 2020

283-298

1 reference

Europe PubMed Central

PubMed publication ID

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23 January 2020

Neonatal administration of N-acetyl-L-aspartyl-L-glutamate induces early neurodegeneration in hippocampus and alters behaviour in young adult rats

1 reference

https://api.crossref.org/works/10.1007%2FS11011-009-9137-6

21 January 2018

Kinetic studies on the hydrogen peroxide elimination by cultured PC12 cells: rate limitation by glucose-6-phosphate dehydrogenase

1 reference

https://api.crossref.org/works/10.1007%2FS11011-009-9137-6

21 January 2018

Regional enzyme development in rat brain. Enzymes associated with glucose utilization

1 reference

https://api.crossref.org/works/10.1007%2FS11011-009-9137-6

21 January 2018

Superoxide dismutase, glutathione peroxidase and catalase in developing rat brain

1 reference

https://api.crossref.org/works/10.1007%2FS11011-009-9137-6

21 January 2018

Accumulation of N-acetyl-L-aspartate in the brain of the tremor rat, a mutant exhibiting absence-like seizure and spongiform degeneration in the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epileptic seizures induced by N-acetyl-L-aspartate in rats: in vivo and in vitro studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of Adriamycin and paraquat on antioxidant enzyme expression in primary rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative damage to proteins: spectrophotometric method for carbonyl assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural history of Canavan disease revealed by proton magnetic resonance spectroscopy (1H-MRS) and diffusion-weighted MRI.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NAAG inhibits KCl-induced [(3)H]-GABA release via mGluR3, cAMP, PKA and L-type calcium conductance

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The clinical course of Canavan disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-Acetyl-L-aspartyl-L-glutamate changes functional and structural properties of rat blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Restricted diffusion in Canavan disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Canavan disease: a review of recent developments

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functions of N-acetylaspartate and N-acetylaspartylglutamate in brain: evidence of a role in maintenance of higher brain integrative activities of information processing and cognition

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphology and ultrastructure of rat hippocampal formation after i.c.v. administration of N-acetyl-L-aspartyl-L-glutamate

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

44 Glutathione peroxidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence supporting a role for N-acetyl-L-aspartate as a molecular water pump in myelinated neurons in the central nervous system. An analytical review

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Canavan disease: a white matter disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aspartoacylase is restricted primarily to myelin synthesizing cells in the CNS: therapeutic implications for Canavan disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catalase in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related changes in reactive oxygen species production in rat brain homogenates

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related changes of oxygen free radical production in the rat brain slice after hypoxia: on-line measurement using enhanced chemiluminescence.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Large neutral amino acids auto exchange when infused by microdialysis into the rat brain: implication for maple syrup urine disease and phenylketonuria

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exercise modulates antioxidant enzyme gene expression in rat myocardium and liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of total antioxidant potential (TRAP) and total antioxidant reactivity from luminol-enhanced chemiluminescence measurements

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterisation of the 1H and 13C NMR spectra of N-acetylaspartylglutamate and its detection in urine from patients with Canavan disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acetylaspartic acid promotes oxidative stress in cerebral cortex of rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spongy degeneration of the brain, Canavan disease: biochemical and molecular findings

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial superoxide production in kainate-induced hippocampal damage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acetylaspartate in the vertebrate brain: metabolism and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of N-acetylaspartate and N-acetylaspartylglutamate biosynthesis by protein kinase activators

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose-6-phosphate dehydrogenase: a "housekeeping" enzyme subject to tissue-specific regulation by hormones, nutrients, and oxidant stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The activation of the rat copper/zinc superoxide dismutase gene by hydrogen peroxide through the hydrogen peroxide-responsive element and by paraquat and heat shock through the same heat shock element

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity of NAAG in vivo is sensitive to NMDA antagonists and mGluR II ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free radical-mediated oxidation of free amino acids and amino acid residues in proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional distribution and pharmacological characteristics of [3H]N-acetyl-aspartyl-glutamate (NAAG) binding sites in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-Acetylated alpha-linked acidic dipeptidase converts N-acetylaspartylglutamate from a neuroprotectant to a neurotoxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation by N-Acetyl-l-Aspartate of Acutely Dissociated Hippocampal Neurons in Rats via Metabotropic Glutamate Receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of total reactive antioxidant potential (TRAP) of tissue homogenates and their cytosols

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraneuronal N-acetylaspartate supplies acetyl groups for myelin lipid synthesis: evidence for myelin-associated aspartoacylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of NAAG by an enzyme-mediated process in rat central nervous system neurons and glia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Cu/Zn-Superoxide Dismutase Expression via the Phosphatidylinositol 3 Kinase/Akt Pathway and Nuclear Factor- B

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electron microscopic and enzyme histochemical studies of the cerebellum in spongy degeneration (van Bogaert and Bertrans type).

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Luminol luminescence induced by 2,2'-Azo-bis(2-amidinopropane) thermolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxygen free radicals in rat limbic structures after kainate-induced seizures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial dysfunction and oxidative stress: cause and consequence of epileptic seizures

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential distribution of NAA and NAAG in human brain as determined by quantitative localized proton MRS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of lipid peroxidation and myocardial damage induced by adriamycin and 4'-epiadriamycin in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein measurement with the Folin phenol reagent

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial oxidative stress and increased seizure susceptibility in Sod2(-/+) mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Canavan disease and the role of N-acetylaspartate in myelin synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acetylaspartylglutamate in Canavan disease: an adverse effector?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Visible chemiluminescence from rat brain homogenates undergoing autoxidation. I. Effect of additives and products accumulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11011-009-9137-6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19294497%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19294497%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

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