(Q46087573)

English

The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men.

scientific article published on 14 March 2009

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scholarly article

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19288077

The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men. (English)

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19288077

1 reference

based on heuristic

inferred from title

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Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19288077

Jens Juul Holst

10

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Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19288077

Oluf Borbye Pedersen

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O Pedersen

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Charlotte Brøns

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C Brøns

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Valeriya Lyssenko

4

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V Lyssenko

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Europe PubMed Central

19 December 2017

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object named as

L Groop

1 reference

Europe PubMed Central

19 December 2017

Carsten Bindslev-Jensen

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object named as

C B Jensen

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19288077

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T Hansen

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19288077

author name string

K Pilgaard

1

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19288077

J H Schou

3

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19288077

L Wegner

5

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19288077

T Vilsbøll

7

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19288077

A Vølund

11

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19288077

P Poulsen

12

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19288077

A A Vaag

15

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19288077

publication date

14 March 2009

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19288077

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19288077

52

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Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19288077

7

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Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19288077

1298-1307

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19288077

https://scigraph.springernature.com/pub.10.1007/s00125-009-1307-x

0 references

TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis

1 reference

https://api.crossref.org/works/10.1007%2FS00125-009-1307-X

21 January 2018

Evidence that enteroglucagon (II) is identical with the C-terminal sequence (residues 33-69) of glicentin

1 reference

https://api.crossref.org/works/10.1007%2FS00125-009-1307-X

21 January 2018

Early differential defects of insulin secretion and action in 19-year-old caucasian men who had low birth weight

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TCF7L2 and type 2 diabetes--we WNT to know

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription Factor TCF7L2 Genetic Study in the French Population: Expression in Human -Cells and Adipose Tissue and Strong Association With Type 2 Diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Highly sensitive enzyme immunoassay of proinsulin immunoreactivity with use of two monoclonal antibodies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TCF7L2 polymorphisms are associated with type 2 diabetes in northern Sweden

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normal secretion and action of the gut incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in young men with low birth weight

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gut incretin hormones in identical twins discordant for non-insulin-dependent diabetes mellitus (NIDDM)--evidence for decreased glucagon-like peptide 1 secretion during oral glucose ingestion in NIDDM twins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt signaling regulates pancreatic beta cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantification of beta-cell function during IVGTT in Type II and non-diabetic subjects: assessment of insulin secretion by mathematical methods

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon receptor knockout mice display increased insulin sensitivity and impaired beta-cell function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The enteroinsular axis may mediate the diabetogenic effects of TCF7L2 polymorphisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Glucagon in Diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variant of Transcription Factor 7-Like 2 (TCF7L2) Gene and the Risk of Type 2 Diabetes in Large Cohorts of U.S. Women and Men

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measuring pre-hepatic insulin secretion using a population model of C-peptide kinetics: accuracy and required sampling schedule.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon receptors on human islet cells contribute to glucose competence of insulin release

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies of pancreatic alpha cell function in normal and diabetic subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contrasting insulin sensitivity of endogenous glucose production rate in subjects with hepatocyte nuclear factor-1beta and -1alpha mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/19288077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-009-1307-X

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19288077

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19288077

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