(Q46098319)

19 December 2017

title

NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism (English)

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19 December 2017

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22

Daniel H Geschwind

1 reference

19 December 2017

Jeffrey D Zaremba

7

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Abdullah Sultan

object named as

Abdullah Sultan

17

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Eliezer Masliah

26

object named as

Eliezer Masliah

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19 December 2017

PMCID

5684358

Alejandro Amador-Arjona

4

object named as

Alejandro Amador-Arjona

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19 December 2017

24

Alexey V Terskikh

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19 December 2017

25

Robert A Rissman

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19 December 2017

author name string

Shichun Tu

1

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19 December 2017

Mohd Waseem Akhtar

2

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19 December 2017

Rosa Maria Escorihuela

3

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19 December 2017

Vivek Swarup

5

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19 December 2017

James Parker

6

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19 December 2017

Timothy Holland

8

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19 December 2017

Neha Bansal

9

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19 December 2017

Daniel R Holohan

10

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19 December 2017

Kevin Lopez

11

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19 December 2017

Scott D Ryan

12

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19 December 2017

Shing Fai Chan

13

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19 December 2017

Li Yan

14

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19 December 2017

Xiaofei Zhang

15

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19 December 2017

Xiayu Huang

16

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19 December 2017

Scott R McKercher

18

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19 December 2017

Rajesh Ambasudhan

19

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19 December 2017

Huaxi Xu

20

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19 December 2017

Yuqiang Wang

21

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19 December 2017

Amanda J Roberts

23

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19 December 2017

Stuart A Lipton

27

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19 December 2017

Nobuki Nakanishi

28

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19 December 2017

language of work or name

English

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publication date

14 November 2017

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19 December 2017

published in

Nature Communications

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19 December 2017

volume

8

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19 December 2017

issue

1

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19 December 2017

page(s)

1488

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19 December 2017

Creative Commons Attribution 4.0 International

copyright license

start time

14 November 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5684358/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/s41467-017-01563-8

0 references

cites work

Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease

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Differential Effects of Pharmacologic and Genetic Modulation of NMDA Receptor Activity on HIV/gp120-Induced Neuronal Damage in an In Vivo Mouse Model

24 May 2018

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Developing Medications Targeting Glutamatergic Dysfunction in Autism: Progress to Date

24 May 2018

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Genome sequencing identifies major causes of severe intellectual disability

24 May 2018

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Enhancement of inhibitory neurotransmission by GABAA receptors having α2,3-subunits ameliorates behavioral deficits in a mouse model of autism

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism

24 May 2018

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SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties

24 May 2018

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Synaptic protein α1-takusan mitigates amyloid-β-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sites

24 May 2018

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Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

24 May 2018

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Selective Pharmacological Modulation of Pyramidal Neurons and Interneurons in the CA1 Region of the Rat Hippocampus

24 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

MEF2C Haploinsufficiency features consistent hyperkinesis, variable epilepsy, and has a role in dorsal and ventral neuronal developmental pathways

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Preclinical research in Rett syndrome: setting the foundation for translational success.

24 May 2018

1 reference

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Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Brain regions and genes affecting limb-clasping responses

24 May 2018

1 reference

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Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Ontology-based meta-analysis of global collections of high-throughput public data

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-κB signaling

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Severe mental retardation, seizures, and hypotonia due to deletions of MEF2C.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

MEF2C haploinsufficiency caused by either microdeletion of the 5q14.3 region or mutation is responsible for severe mental retardation with stereotypic movements, epilepsy and/or cerebral malformations

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

A novel microdeletion syndrome involving 5q14.3-q15: clinical and molecular cytogenetic characterization of three patients

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Periventricular heterotopia, mental retardation, and epilepsy associated with 5q14.3-q15 deletion

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Identifying autism loci and genes by tracing recent shared ancestry

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cells

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

MeCP2, a key contributor to neurological disease, activates and represses transcription

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Memantine as adjunctive therapy in children diagnosed with autistic spectrum disorders: an observation of initial clinical response and maintenance tolerability

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Takusan: a large gene family that regulates synaptic activity

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

brawn for brains: the role of MEF2 proteins in the developing nervous system

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Immunohistochemical localization of candidates for vesicular glutamate transporters in the rat brain

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

The existence of a second vesicular glutamate transporter specifies subpopulations of glutamatergic neurons.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Synergistic activation of the N-methyl-D-aspartate receptor subunit 1 promoter by myocyte enhancer factor 2C and Sp1

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

The expression of MEF2 genes is implicated in CNS neuronal differentiation

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

An automated method for studying exploratory and stereotyped behaviour in rats

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Refining the phenotype associated with MEF2C point mutations

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Late-onset gain of skills and peculiar jugular pit in an 11-year-old girl with 5q14.3 microdeletion including MEF2C.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Mutations in MEF2C from the 5q14.3q15 microdeletion syndrome region are a frequent cause of severe mental retardation and diminish MECP2 and CDKL5 expression.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Refining the phenotype associated with MEF2C haploinsufficiency.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5684358

5q14.3 neurocutaneous syndrome: A novel continguous gene syndrome caused by simultaneous deletion of RASA1 and MEF2C

15 August 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41467-017-01563-8

Clinically relevant single gene or intragenic deletions encompassing critical neurodevelopmental genes in patients with developmental delay, mental retardation, and/or autism spectrum disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41467-017-01563-8

7 January 2021

Interstitial deletion 5q14.3q21.3 with MEF2C haploinsufficiency and mild phenotype: when more is less

1 reference

https://api.crossref.org/works/10.1038%2FS41467-017-01563-8

7 January 2021

The pharmacology of aminoadamantane nitrates

1 reference

https://api.crossref.org/works/10.1038%2FS41467-017-01563-8

7 January 2021

The reliability of the hole-board apparatus

1 reference

https://api.crossref.org/works/10.1038%2FS41467-017-01563-8

7 January 2021

10.1038/S41467-017-01563-8

Identifiers

DOI

1 reference

19 December 2017

Dimensions Publication ID

ADS bibcode

2017NatCo...8.1488T

0 references

0 references

1 reference

19 December 2017

PubMed ID

29133852

1 reference

19 December 2017