(Q46118117)

19 December 2017

title

Stabilization and activation of p53 downregulates mTOR signaling through AMPK in mantle cell lymphoma (English)

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19 December 2017

author name string

E Drakos

1

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19 December 2017

V Atsaves

2

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19 December 2017

J Li

3

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19 December 2017

V Leventaki

4

1 reference

19 December 2017

M Andreeff

5

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19 December 2017

L J Medeiros

6

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19 December 2017

G Z Rassidakis

7

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19 December 2017

publication date

19 February 2009

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19 December 2017

published in

Leukemia

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19 December 2017

volume

23

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19 December 2017

issue

4

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19 December 2017

page(s)

784-790

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19 December 2017

https://scigraph.springernature.com/pub.10.1038/leu.2008.348

exact match

0 references

cites work

Restoration of p53 function leads to tumour regression in vivo

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

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Modeling the therapeutic efficacy of p53 restoration in tumors

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Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

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Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo

21 January 2018

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The coordinate regulation of the p53 and mTOR pathways in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.348

Pathogenesis of mantle-cell lymphoma: all oncogenic roads lead to dysregulation of cell cycle and DNA damage response pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.348

Activation of mammalian target of rapamycin signaling promotes cell cycle progression and protects cells from apoptosis in mantle cell lymphoma

21 January 2018

1 reference

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The p53-Mdm2 module and the ubiquitin system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.348

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

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Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

21 January 2018

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MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

21 January 2018

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Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia

21 January 2018

1 reference

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Inhibition of p53-murine double minute 2 interaction by nutlin-3A stabilizes p53 and induces cell cycle arrest and apoptosis in Hodgkin lymphoma

21 January 2018

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Potential role for concurrent abnormalities of the cyclin D1, p16CDKN2 and p15CDKN2B genes in certain B cell non-Hodgkin's lymphomas. Functional studies in a cell line (Granta 519).

21 January 2018

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Inhibition of Akt increases p27Kip1 levels and induces cell cycle arrest in anaplastic large cell lymphoma

21 January 2018

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Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines

21 January 2018

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Establishment and characterization of a new mantle cell lymphoma cell line, Mino

21 January 2018

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Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIM.

21 January 2018

1 reference

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Upstream and downstream of mTOR

21 January 2018

1 reference

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Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma

21 January 2018

1 reference

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Functional integrity of the p53-mediated apoptotic pathway induced by the nongenotoxic agent nutlin-3 in B-cell chronic lymphocytic leukemia (B-CLL).

21 January 2018

1 reference

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

21 January 2018

1 reference

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The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.348

21 January 2018

Identifiers

DOI

10.1038/LEU.2008.348

1 reference

19 December 2017

PubMed ID

19225536

1 reference

19 December 2017