(Q46132539)

19 December 2017

title

Mechanisms of constitutive activation of Janus kinase 2-V617F revealed at the atomic level through molecular dynamics simulations (English)

1 reference

19 December 2017

5

Hagop Kantarjian

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19 December 2017

4

Francis Giles

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19 December 2017

6

Maher Albitar

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19 December 2017

Tai-Sung Lee

1

1 reference

19 December 2017

Wanlong Ma

series ordinal

2

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19 December 2017

Xi Zhang

series ordinal

3

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19 December 2017

language of work or name

English

0 references

publication date

1 April 2009

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19 December 2017

published in

Cancer

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19 December 2017

volume

115

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19 December 2017

issue

8

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19 December 2017

page(s)

1692-1700

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19 December 2017

Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

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The Janus kinases (Jaks)

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The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus

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Identification of the Jak/Stat proteins as novel downstream targets of EphA4 signaling in muscle: implications in the regulation of acetylcholinesterase expression

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Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

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Jak2 is essential for signaling through a variety of cytokine receptors

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Jak2: normal function and role in hematopoietic disorders

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Detection of JAK2 V617F as a first intention diagnostic test for erythrocytosis.

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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

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Advances in the molecular characterization of Philadelphia-negative chronic myeloproliferative disorders

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JAK2 V617F in myeloid disorders: what do we know now, and where are we headed?

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The JAK2V617F tyrosine kinase mutation in myeloproliferative disorders: status report and immediate implications for disease classification and diagnosis

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A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

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7 January 2021

A gain-of-function mutation of JAK2 in myeloproliferative disorders

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7 January 2021

Identification of an acquired JAK2 mutation in polycythemia vera

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7 January 2021

Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders

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7 January 2021

The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both "atypical" myeloproliferative disorders and myelodysplastic syndromes

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7 January 2021

A role for JAK2 mutations in myeloproliferative diseases

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7 January 2021

JAK2 mutation in essential thrombocythaemia: clinical associations and long-term prognostic relevance

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7 January 2021

Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains

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7 January 2021

The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor

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7 January 2021

Prediction of the structure of human Janus kinase 2 (JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation

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7 January 2021

Prediction of the structure of human Janus kinase 2 (JAK2) comprising JAK homology domains 1 through 7.

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7 January 2021

On the molecular origins of the chronic myeloproliferative disorders: it all makes sense

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7 January 2021

JAK2, the JAK2 V617F mutant and cytokine receptors.

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7 January 2021

Loss of the JAK2 intramolecular auto-inhibition mechanism is predicted by structural modelling of a novel exon 12 insertion mutation in a case of idiopathic erythrocytosis

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7 January 2021

Comparison of simple potential functions for simulating liquid water

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7 January 2021

VMD: visual molecular dynamics

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7 January 2021

Scalable molecular dynamics with NAMD

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7 January 2021

CHARMM: A program for macromolecular energy, minimization, and dynamics calculations

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7 January 2021

Molecular dynamics simulations at constant pressure and/or temperature

1 reference

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7 January 2021

Canonical dynamics: Equilibrium phase-space distributions

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7 January 2021

Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes

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7 January 2021

2.1 and 1.8 A average C(alpha) RMSD structure predictions on two small proteins, HP-36 and s15.

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7 January 2021

Mimicking the action of folding chaperones in molecular dynamics simulations: Application to the refinement of homology-based protein structures

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7 January 2021

Can molecular dynamics simulations provide high-resolution refinement of protein structure?

1 reference

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7 January 2021

JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor.

1 reference

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7 January 2021

A smooth particle mesh Ewald method

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7 January 2021

Identifiers

DOI

10.1002/CNCR.24183

1 reference

19 December 2017

1 reference

19 December 2017