(Q46144051)

19 December 2017

title

RAS, FLT3, and TP53 mutations in therapy-related myeloid malignancies with abnormalities of chromosomes 5 and 7. (English)

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19 December 2017

author

Richard A. Larson

6

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19 December 2017

Michelle M Le Beau

7

object named as

Michelle M Le Beau

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19 December 2017

author name string

Lucy E Side

1

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19 December 2017

Nicole P Curtiss

2

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19 December 2017

Kathryn Teel

3

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19 December 2017

Christian Kratz

4

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19 December 2017

Pauline W Wang

5

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19 December 2017

Kevin M Shannon

8

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19 December 2017

publication date

1 March 2004

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19 December 2017

Genes, Chromosomes and Cancer

published in

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19 December 2017

volume

39

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19 December 2017

issue

3

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19 December 2017

page(s)

217-223

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19 December 2017

Mice over-expressing human O6 alkylguanine-DNA alkyltransferase selectively reduce O6 methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea.

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A PMLRARalpha transgene initiates murine acute promyelocytic leukemia

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Internal tandem duplications of the FLT3 and MLL genes are mainly observed in atypical cases of therapy-related acute myeloid leukemia with a normal karyotype and are unrelated to type of previous therapy

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Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q, a complex karyotype, and a poor progno

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Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

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7 January 2021

Distinct genetic involvement of the TP53 gene in therapy-related leukemia and myelodysplasia with chromosomal losses of Nos 5 and/or 7 and its possible relationship to replication error phenotype

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7 January 2021

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FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

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7 January 2021

Candidate gene isolation and comparative analysis of a commonly deleted segment of 7q22 implicated in myeloid malignancies.

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Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q)

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Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia

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7 January 2021

Clinical and cytogenetic correlations in 63 patients with therapy-related myelodysplastic syndromes and acute nonlymphocytic leukemia: further evidence for characteristic abnormalities of chromosomes no. 5 and 7

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7 January 2021

Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases

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Monosomy 7 myelodysplastic syndrome and other second malignant neoplasms in children with neurofibromatosis type 1

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Molecular evolution of acute myeloid leukaemia in relapse: unstable N-ras and FLT3 genes compared with p53 gene.

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N-ras mutation in 7,12-dimethylbenz[a]anthracene (DMBA)-induced erythroleukemia in Long-Evans rats

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Radiotherapy- and chemotherapy-induced myelodysplasia and acute myeloid leukemia. A review

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7 January 2021

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Expression profiling of CD34+ hematopoietic stem/ progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia.

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Chronic myelomonocytic leukemia: Tel-a-kinase what Ets all about

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Genetic analysis of chemoresistance in primary murine lymphomas.

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A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

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7 January 2021

Dissecting p53 tumor suppressor functions in vivo

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7 January 2021

Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders

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7 January 2021

Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series.

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7 January 2021

Possible co-existence of RAS activation and monosomy 7 in the leukaemic transformation of myelodysplastic syndromes

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7 January 2021

FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia.

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7 January 2021

ras Oncogene Activation and Occupational Exposures in Acute Myeloid Leukemia

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7 January 2021

Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

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7 January 2021

Therapy-related myeloid leukemia

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7 January 2021

Identifiers

DOI

10.1002/GCC.10320

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19 December 2017

PubMed ID

14732923

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19 December 2017