(Q46151927)

English

Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors.

scientific article published in April 2005

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scholarly article

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11 January 2020

Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15899696%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Schistosoma japonicum

object named as

Schistosoma japonicum

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based on heuristic

inferred from title

9

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11 January 2020

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11 January 2020

8

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Pavel Majer

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11 January 2020

James H McKerrow

7

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James H McKerrow

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11 January 2020

Jiří Vondrášek

10

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Jirí Vondrásek

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11 January 2020

Martin Hradilek

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Martin Hradilek

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11 January 2020

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Conor R Caffrey

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11 January 2020

Lenka Placha

2

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11 January 2020

Jirí Dostál

5

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11 January 2020

Mohammed Sajid

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11 January 2020

publication date

1 April 2005

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11 January 2020

Biological Chemistry

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11 January 2020

386

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11 January 2020

4

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11 January 2020

339-349

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11 January 2020

Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

Cloning and characterization of the Schistosoma japonicum aspartic proteinase involved in hemoglobin degradation.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

The secreted aspartic proteinases as a new target in the therapy of candidiasis

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

The Protein Data Bank

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

Hemoglobin-degrading, aspartic proteases of blood-feeding parasites: substrate specificity revealed by homology models.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

Proteolysis of human hemoglobin by schistosome cathepsin D.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

Blood 'n' guts: an update on schistosome digestive peptidases

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

The crystal structure of a major secreted aspartic proteinase from Candida albicans in complexes with two inhibitors

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

Databases for protein-ligand complexes

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

A priori prediction of activity for HIV-1 protease inhibitors employing energy minimization in the active site.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

Structure-based subsite specificity mapping of human cathepsin D using statine-based inhibitors

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

Structural basis of oncogenic activation caused by point mutations in the kinase domain of the MET proto-oncogene: modeling studies

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

Neighborhood behavior: a useful concept for validation of "molecular diversity" descriptors

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

The immunobiology of schistosomiasis

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

Secreted aspartic proteases of Candida albicans, Candida tropicalis, Candida parapsilosis and Candida lusitaniae. Inhibition with peptidomimetic inhibitors

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

Insights into the selective inhibition of Candida albicans secreted aspartyl protease: a docking analysis study

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

Schistosoma mansoni and S. japonicum: comparison of levels of ultraviolet irradiation for vaccination of mice with cercariae

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

Identification and characterisation of an aspartyl protease inhibitor homologue as a major allergen of Trichostrongylus colubriformis.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

Exploring the subsite specificity of Schistosoma mansoni aspartyl hemoglobinase through comparative molecular modelling

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

Inhibitors of HIV-1 protease: a major success of structure-assisted drug design

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

Cysteine protease inhibitors block schistosome hemoglobin degradation in vitro and decrease worm burden and egg production in vivo

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

Hookworm aspartic protease, Na-APR-2, cleaves human hemoglobin and serum proteins in a host-specific fashion

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.041

21 January 2018

Identifiers

10.1515/BC.2005.041

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15899696%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15899696%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

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