(Q46167814)

20 December 2017

title

A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia (English)

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20 December 2017

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Mark J Evans

1

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20 December 2017

Paige E Mahaney

2

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20 December 2017

Lisa Borges-Marcucci

3

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20 December 2017

KehDih Lai

4

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20 December 2017

Shuguang Wang

5

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20 December 2017

Julie A Krueger

6

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20 December 2017

Stephen J Gardell

7

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20 December 2017

Christine Huard

8

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20 December 2017

Robert Martinez

9

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20 December 2017

George P Vlasuk

10

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20 December 2017

Douglas C Harnish

11

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20 December 2017

publication date

8 January 2009

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20 December 2017

American Journal of Physiology - Gastrointestinal and Liver Physiology

published in

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20 December 2017

volume

296

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20 December 2017

issue

3

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20 December 2017

page(s)

G543-52

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20 December 2017

Bile acid metabolism in hereditary forms of hypertriglyceridemia: evidence for an increased synthesis rate in monogenic familial hypertriglyceridemia

cites work

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

The establishment of a novel non-alcoholic steatohepatitis model accompanied with obesity and insulin resistance in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter by nuclear receptors liver receptor homologue-1 and small heterodimer partner: a mechanism for differential regulation of cholesterol synthesis and uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

The use of colesevelam hydrochloride in the treatment of dyslipidemia: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

Regulation of hepatic Insig-2 by the farnesoid X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

The farnesoid X-receptor is an essential regulator of cholesterol homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

Activation of the farnesoid X receptor represses PCSK9 expression in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

FXR, a multipurpose nuclear receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

Farnesoid X receptor is essential for normal glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

Identification of a nuclear receptor for bile acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

Bile acids enhance low density lipoprotein receptor gene expression via a MAPK cascade-mediated stabilization of mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

Chenodiol (chenodeoxycholic acid) for dissolution of gallstones: the National Cooperative Gallstone Study. A controlled trial of efficacy and safety

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

Thyroid hormone regulation and cholesterol metabolism are connected through Sterol Regulatory Element-Binding Protein-2 (SREBP-2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

Guggulipid for the treatment of hypercholesterolemia: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

A natural product that lowers cholesterol as an antagonist ligand for FXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

Chemical genomics: functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPGI.90585.2008

21 January 2018

Identifiers

DOI

10.1152/AJPGI.90585.2008

1 reference

20 December 2017

PubMed ID

19136377

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20 December 2017