(Q46231022)

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Adenovirus 5 E1A is responsible for increased expression of insulin receptor substrate 4 in established adenovirus 5-transformed cell lines and interacts with IRS components activating the PI3 kinase/Akt signalling pathway

scientific article published on 24 November 2008

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/19029952

Adenovirus 5 E1A is responsible for increased expression of insulin receptor substrate 4 in established adenovirus 5-transformed cell lines and interacts with IRS components activating the PI3 kinase/Akt signalling pathway (English)

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/19029952

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N J Shimwell

1

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Europe PubMed Central

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20 December 2017

http://europepmc.org/abstract/MED/19029952

A Martin

2

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/19029952

R K Bruton

3

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Europe PubMed Central

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20 December 2017

http://europepmc.org/abstract/MED/19029952

A N Blackford

4

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/19029952

G G Sedgwick

5

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/19029952

P H Gallimore

6

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/19029952

A S Turnell

7

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/19029952

R J A Grand

8

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20 December 2017

http://europepmc.org/abstract/MED/19029952

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24 November 2008

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/19029952

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/19029952

28

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/19029952

5

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/19029952

686-697

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/19029952

https://scigraph.springernature.com/pub.10.1038/onc.2008.417

0 references

Characterization and regulation of the mouse insulin receptor substrate gene promoter

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Comprehensive sequence analysis of the E1A proteins of human and simian adenoviruses.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Comparative sequence analysis of the largest E1A proteins of human and simian adenoviruses

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

The interaction of the hnRNP family member E1B-AP5 with p53

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

C-terminal-binding protein interacting protein binds directly to adenovirus early region 1A through its N-terminal region and conserved region 3.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Two New Substrates in Insulin Signaling, IRS5/DOK4 and IRS6/DOK5

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Role of insulin receptor substrate-4 in IGF-I-stimulated HEPG2 proliferation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Insulin receptor substrate 4 supports insulin- and interleukin 4-stimulated proliferation of hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Adenovirus vectors activate survival pathways in lung epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Adenovirus-5 E1A: paradox and paradigm

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Adenovirus E1A: remodelling the host cell, a life or death experience

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Subregions of the adenovirus E1A transactivation domain target multiple components of the TFIID complex

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

The zinc finger region of the adenovirus E1A transactivating domain complexes with the TATA box binding protein

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Immortalization by c-myc, H-ras, and Ela oncogenes induces differential cellular gene expression and growth factor responses

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

E1a activation of insulin receptor gene expression is mediated by Sp1-binding sites

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Adenovirus E1A activation domain binds the basic repeat in the TATA box transcription factor

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Promoter targeting by adenovirus E1a through interaction with different cellular DNA-binding domains.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Insulin receptor substrate 3 is not essential for growth or glucose homeostasis.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

AKT/PKB signaling: navigating downstream

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Interaction between Brk kinase and insulin receptor substrate-4.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Insulin receptor substrate-4 enhances insulin-like growth factor-I-induced cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Recruitment of CBP/p300, TATA-binding protein, and S8 to distinct regions at the N terminus of adenovirus E1A.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Roles for APIS and the 20S proteasome in adenovirus E1A-dependent transcription

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

JC virus large T-antigen and IGF-I signaling system merge to affect DNA repair and genomic integrity

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Repression of insulin gene expression by adenovirus type 5 E1a proteins

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Critical nodes in signalling pathways: insights into insulin action

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Differential roles of insulin receptor substrates in brown adipocyte differentiation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

In vivo association of adenovirus large E1A protein with the human mediator complex in adenovirus-infected and -transformed cells.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Identification of serum biomarkers for colon cancer by proteomic analysis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

The IRS-signalling system: a network of docking proteins that mediate insulin action

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Regulating insulin signaling and beta-cell function through IRS proteins

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Cellular targets for transformation by the adenovirus E1A proteins

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Association of insulin receptor substrate 1 with simian virus 40 large T antigen

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

A family of transcriptional adaptor proteins targeted by the E1A oncoprotein

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

21 January 2018

Antitumor effect of E1A in ovarian cancer by cytoplasmic sequestration of activated ERK by PEA15.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

31 March 2020

Transformation by the simian virus 40 T antigen is regulated by IGF-I receptor and IRS-1 signaling

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

31 March 2020

Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

31 March 2020

T-antigen of the human polyomavirus JC attenuates faithful DNA repair by forcing nuclear interaction between IRS-1 and Rad51

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.417

31 March 2020

Identifiers

10.1038/ONC.2008.417

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/19029952

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/19029952

ResearchGate publication ID

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