(Q36602630)

15 August 2017

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title

Regulating insulin signaling and beta-cell function through IRS proteins (English)

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15 August 2017

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Morris F White

1

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15 August 2017

publication date

1 July 2006

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Canadian Journal of Physiology and Pharmacology

15 August 2017

published in

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15 August 2017

volume

84

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15 August 2017

issue

7

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15 August 2017

page(s)

725-737

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The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

15 August 2017

cites work

1 reference

Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease

21 January 2018

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The critical features and the mechanism of inhibition of a kinase interaction motif-based peptide inhibitor of JNK.

21 January 2018

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CAP defines a second signalling pathway required for insulin-stimulated glucose transport

21 January 2018

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Active Rho kinase (ROK-alpha ) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells.

21 January 2018

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An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control

21 January 2018

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Role of brain insulin receptor in control of body weight and reproduction

21 January 2018

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IRS pleckstrin homology domains bind to acidic motifs in proteins

21 January 2018

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Knockout studies defining different roles for melanocortin receptors in energy homeostasis

21 January 2018

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Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation

21 January 2018

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A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism

21 January 2018

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Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

21 January 2018

1 reference

Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin

21 January 2018

1 reference

COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases

21 January 2018

1 reference

Essential role of STAT3 in body weight and glucose homeostasis

21 January 2018

1 reference

Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.

21 January 2018

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SCF and Cullin/Ring H2-based ubiquitin ligases

21 January 2018

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Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes

21 January 2018

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Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action

21 January 2018

1 reference

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene

21 January 2018

1 reference

Signaling pathways: the benefits of good communication

21 January 2018

1 reference

Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells.

21 January 2018

1 reference

Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas

21 January 2018

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Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

21 January 2018

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Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases

21 January 2018

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Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling

21 January 2018

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Positive and negative regulatory role of insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) serine/threonine phosphorylation.

21 January 2018

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Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta

21 January 2018

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MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632

21 January 2018

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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

21 January 2018

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Role of mTOR in the degradation of IRS-1: regulation of PP2A activity

21 January 2018

1 reference

Transactivation of ErbB2 and ErbB3 by tumor necrosis factor-alpha and anisomycin leads to impaired insulin signaling through serine/threonine phosphorylation of IRS proteins

21 January 2018

1 reference

A central role for JNK in obesity and insulin resistance

21 January 2018

1 reference

The role of TNFalpha and TNF receptors in obesity and insulin resistance

21 January 2018

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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

21 January 2018

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Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance

21 January 2018

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Targeted disruption of the melanocortin-4 receptor results in obesity in mice

21 January 2018

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

21 January 2018

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Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

21 January 2018

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An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue

21 January 2018

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5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside

21 January 2018

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cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.

21 January 2018

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Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells

21 January 2018

1 reference

Insulin-promoter-factor 1 is required for pancreas development in mice

21 January 2018

1 reference

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

21 January 2018

1 reference

SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase

21 January 2018

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Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

21 January 2018

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Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice

21 January 2018

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c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade

21 January 2018

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TSC2: filling the GAP in the mTOR signaling pathway

21 January 2018

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Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase

21 January 2018

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Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins

21 January 2018

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Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck

21 January 2018

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Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development.

21 January 2018

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Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man.

21 January 2018

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Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action

21 January 2018

1 reference

Leptin receptor signaling and the regulation of mammalian physiology

21 January 2018

1 reference

The delicate balance between fat and muscle: adipokines in metabolic disease and musculoskeletal inflammation

21 January 2018

1 reference

Tyrosine phosphorylation of p62(Dok) induced by cell adhesion and insulin: possible role in cell migration

21 January 2018

1 reference

Central melanocortin receptors regulate insulin action

21 January 2018

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Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

21 January 2018

1 reference

A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.

21 January 2018

1 reference

Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved

21 January 2018

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Signaling through scaffold, anchoring, and adaptor proteins

21 January 2018

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The glucagon-like peptides: a double-edged therapeutic sword?

21 January 2018

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Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo.

21 January 2018

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Adiponectin acts in the brain to decrease body weight.

21 January 2018

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Insulin resistance and compensatory hyperinsulinemia: the key player between cigarette smoking and cardiovascular disease?

21 January 2018

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Signal transduction pathways that regulate eukaryotic protein synthesis

21 January 2018

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Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

21 January 2018

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Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2.

21 January 2018

1 reference

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

21 January 2018

1 reference

Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786

21 January 2018

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Tyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptor

21 January 2018

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IRS-1 regulation in health and disease.

21 January 2018

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Insulin in the brain: a hormonal regulator of energy balance

21 January 2018

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Signaling differences from the A and B isoforms of the insulin receptor (IR) in 32D cells in the presence or absence of IR substrate-1.

21 January 2018

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Alternative splicing of human insulin receptor messenger RNA.

21 January 2018

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Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

21 January 2018

1 reference

Adiponectin and protection against type 2 diabetes mellitus

21 January 2018

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Platelet-derived growth factor inhibits insulin stimulation of insulin receptor substrate-1-associated phosphatidylinositol 3-kinase in 3T3-L1 adipocytes without affecting glucose transport

21 January 2018

1 reference

Activation of SOCS-3 by resistin

21 January 2018

1 reference

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

21 January 2018

1 reference

Type 2 diabetes: principles of pathogenesis and therapy

21 January 2018

1 reference

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

21 January 2018

1 reference

Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin

21 January 2018

1 reference

Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.

21 January 2018

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Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

21 January 2018

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Positive and Negative Roles of p85α and p85β Regulatory Subunits of Phosphoinositide 3-Kinase in Insulin Signaling

21 January 2018

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

21 January 2018

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Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function

21 January 2018

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Obesity is associated with macrophage accumulation in adipose tissue

21 January 2018

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Disruption of IRS-2 causes type 2 diabetes in mice

21 January 2018

1 reference

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

21 January 2018

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Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

21 January 2018

1 reference

The IRS-signalling system during insulin and cytokine action

21 January 2018

1 reference

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

21 January 2018

1 reference

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

21 January 2018

1 reference

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

21 January 2018

1 reference

Upregulation of insulin receptor substrate-2 in pancreatic β cells prevents diabetes

21 January 2018

1 reference

IRS-2 pathways integrate female reproduction and energy homeostasis

21 January 2018

1 reference

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1139/Y06-008

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15 August 2017

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