(Q46237124)

English

Irreversible CYP3A inhibition accompanied by plasma protein-binding displacement: a comparative analysis in subjects with normal and impaired liver function.

scientific article published on 19 November 2008

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17 January 2020

Irreversible CYP3A inhibition accompanied by plasma protein-binding displacement: a comparative analysis in subjects with normal and impaired liver function (English)

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17 January 2020

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17 January 2020

Luigi Quintieri

4

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17 January 2020

author name string

R Orlando

1

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17 January 2020

P Pegoraro

3

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17 January 2020

P Palatini

5

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17 January 2020

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19 November 2008

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17 January 2020

Clinical Pharmacology & Therapeutics

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17 January 2020

85

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17 January 2020

3

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17 January 2020

319-326

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17 January 2020

Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential--toward a consensus

1 reference

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Predicting inhibitory drug-drug interactions and evaluating drug interaction reports using inhibition constants

1 reference

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Evaluation of inhibitory drug interactions during drug development: genetic polymorphisms must be considered

1 reference

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Hepatic cytochrome P450 regulation in disease states

1 reference

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21 January 2018

Metabolism-based drug-drug interactions: what determines individual variability in cytochrome P450 induction?

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Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function

1 reference

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Enzyme inhibition and induction in liver disease.

1 reference

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21 January 2018

Cationic drug pharmacokinetics in diseased livers determined by fibrosis index, hepatic protein content, microsomal activity, and nature of drug

1 reference

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21 January 2018

The Karolinska cocktail for phenotyping of five human cytochrome P450 enzymes.

1 reference

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21 January 2018

Metabolism and elimination of quinine in healthy volunteers

1 reference

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21 January 2018

Pharmacokinetics and pharmacodynamics of intravenous midazolam in patients with severe alcoholic cirrhosis

1 reference

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Pharmacokinetics of quinine, chloroquine and amodiaquine. Clinical implications

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Alpha 1-acid glycoprotein (orosomucoid) and plasma protein binding of quinine in falciparum malaria

1 reference

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21 January 2018

Severity of cirrhosis and the relationship of alpha 1-acid glycoprotein concentration to plasma protein binding of lidocaine.

1 reference

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21 January 2018

The plasma protein binding of basic drugs

1 reference

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21 January 2018

The pharmacokinetics of quinine in patients with hepatitis

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2008.216

21 January 2018

Pharmacokinetics of quinine in chronic liver disease

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2008.216

21 January 2018

Differences in the binding of quinine and quinidine to plasma proteins

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2008.216

21 January 2018

Plasma protein binding of quinine: binding to human serum albumin, alpha 1-acid glycoprotein and plasma from patients with malaria

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2008.216

21 January 2018

Quinine pharmacokinetics in chronic haemodialysis patients

1 reference

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21 January 2018

Disposition of quinine in plasma, red blood cells and saliva after oral and intravenous administration to healthy adult Africans.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2008.216

21 January 2018

Changes in plasma protein binding have little clinical relevance

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2008.216

21 January 2018

Prediction of plasma protein binding displacement and its implications for quantitative assessment of metabolic drug-drug interactions from in vitro data

1 reference

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21 January 2018

Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4?

1 reference

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21 January 2018

Pharmacogenetics of cytochromes P450.

1 reference

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21 January 2018

Plasma protein binding displacement interactions--why are they still regarded as clinically important?

1 reference

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21 January 2018

Disposition of oral quinine in acute falciparum malaria

1 reference

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21 January 2018

Linear pharmacokinetic equations allowing direct calculation of many needed pharmacokinetic parameters from the coefficients and exponents of polyexponential equations which have been fitted to the data

1 reference

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21 January 2018

Liver dysfunction markedly decreases the inhibition of cytochrome P450 1A2–mediated theophylline metabolism by fluvoxamine

1 reference

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7 January 2021

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Inhibition and induction of cytochrome P450 and the clinical implications

1 reference

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7 January 2021

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Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring

1 reference

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7 January 2021

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The effect of sulphinpyrazone on oxidative drug metabolism in man: inhibition of tolbutamide elimination

1 reference

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7 January 2021

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Binding of quinine to plasma proteins in falciparum malaria

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2008.216

7 January 2021

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Increased uptake of quinine into the brain by inhibition of P-glycoprotein

1 reference

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7 January 2021

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Stereoselective renal tubular secretion of quinidine and quinine

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7 January 2021

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Clinical pharmacokinetics in the treatment of tropical diseases. Some applications and limitations

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Quantitative determination of the macrolide antibiotics erythromycin, roxithromycin, azithromycin and clarithromycin in human serum by high-performance liquid chromatography using pre-column derivatization with 9-fluorenylmethyloxycarbonyl chloride

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Identifiers

10.1038/CLPT.2008.216

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19020496%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19020496%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

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