(Q46285110)

21 December 2017

title

Conditional disruption of the prolyl hydroxylase domain-containing protein 2 (Phd2) gene defines its key role in skeletal development (English)

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21 December 2017

author name string

Shaohong Cheng

1

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21 December 2017

Weirong Xing

2

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21 December 2017

Sheila Pourteymoor

3

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21 December 2017

Subburaman Mohan

4

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21 December 2017

publication date

1 October 2014

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21 December 2017

Journal of Bone and Mineral Research

published in

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21 December 2017

volume

29

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21 December 2017

issue

10

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21 December 2017

page(s)

2276-2286

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21 December 2017

Osteoporosis. Definition and clinical presentation

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Pathogenesis of osteoporosis: concepts, conflicts, and prospects

21 January 2018

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Spontaneous fractures in the mouse mutant sfx are caused by deletion of the gulonolactone oxidase gene, causing vitamin C deficiency

21 January 2018

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21 January 2018

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Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study

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Antioxidant intake and risk of osteoporotic hip fracture in Utah: an effect modified by smoking status.

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The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation

21 January 2018

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Ascorbic acid regulates osterix expression in osteoblasts by activation of prolyl hydroxylase and ubiquitination-mediated proteosomal degradation pathway

21 January 2018

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Effects of ascorbic acid on collagen matrix formation and osteoblast differentiation in murine MC3T3-E1 cells

21 January 2018

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Ascorbic acid-independent synthesis of collagen in mice

21 January 2018

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Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

21 January 2018

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Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents

21 January 2018

1 reference

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

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Mammalian EGLN genes have distinct patterns of mRNA expression and regulation

21 January 2018

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Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

21 January 2018

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Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

21 January 2018

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Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

21 January 2018

1 reference

Cre recombinase-mediated gene targeting of mesenchymal cells.

21 January 2018

1 reference

Conditional deletion of insulin-like growth factor-I in collagen type 1alpha2-expressing cells results in postnatal lethality and a dramatic reduction in bone accretion

21 January 2018

1 reference

Prepubertal OVX increases IGF-I expression and bone accretion in C57BL/6J mice

21 January 2018

1 reference

Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee

21 January 2018

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Transgenic overexpression of ephrin b1 in bone cells promotes bone formation and an anabolic response to mechanical loading in mice

21 January 2018

1 reference

Targeted disruption of nuclear factor erythroid-derived 2-like 1 in osteoblasts reduces bone size and bone formation in mice

21 January 2018

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Haploinsufficiency of osterix in chondrocytes impairs skeletal growth in mice

21 January 2018

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Connexin 48.5 is required for normal cardiovascular function and lens development in zebrafish embryos

21 January 2018

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Targeted disruption of ephrin B1 in cells of myeloid lineage increases osteoclast differentiation and bone resorption in mice

21 January 2018

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Multiple genetic loci from CAST/EiJ chromosome 1 affect vBMD either positively or negatively in a C57BL/6J background

21 January 2018

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Identification of gender-specific candidate genes that influence bone microarchitecture in chromosome 1

21 January 2018

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A conserved family of prolyl-4-hydroxylases that modify HIF

21 January 2018

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Role of HIF-1alpha in skeletal development.

21 January 2018

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The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development.

21 January 2018

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Hypoxia-inducible factors 1alpha and 2alpha exert both distinct and overlapping functions in long bone development.

21 January 2018

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A knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficiency mechanism

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JBMR.2258

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21 December 2017

PubMed ID

24753072

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21 December 2017