(Q46335868)

English

Neurokinin1 antagonists potentiate antidepressant properties of serotonin reuptake inhibitors, yet blunt their anxiogenic actions: a neurochemical, electrophysiological, and behavioral characterization

scientific article published in October 2008

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18830239

Neurokinin1 antagonists potentiate antidepressant properties of serotonin reuptake inhibitors, yet blunt their anxiogenic actions: a neurochemical, electrophysiological, and behavioral characterization (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18830239

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electrophysiology

1 reference

based on heuristic

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author name string

Alain Gobert

1

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18830239

Mauricette Brocco

2

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18830239

Anne Dekeyne

3

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18830239

Benjamin Di Cara

4

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18830239

Gaëlle Bouchez

5

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18830239

Françoise Lejeune

6

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18830239

Robert L Gannon

7

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18830239

Mark J Millan

8

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18830239

language of work or name

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publication date

1 October 2008

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18830239

Neuropsychopharmacology

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18830239

34

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18830239

4

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18830239

1039-1056

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18830239

https://scigraph.springernature.com/pub.10.1038/npp.2008.176

0 references

Comparison of the phenotype of NK1R-/- mice with pharmacological blockade of the substance P (NK1 ) receptor in assays for antidepressant and anxiolytic drugs

1 reference

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21 January 2018

The somatodendritic release of dopamine in the ventral tegmental area and its regulation by afferent transmitter systems.

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Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission

1 reference

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Substance P injected into the dorsal periaqueductal gray causes anxiogenic effects similar to the long-term isolation as assessed by ultrasound vocalizations measurements

1 reference

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Permissive role of neurokinin NK(3) receptors in NK(1) receptor-mediated activation of the locus coeruleus revealed by SR 142801.

1 reference

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Cellular and behavioural profile of the novel, selective neurokinin1 receptor antagonist, vestipitant: a comparison to other agents

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Antidepressant-like properties of the anti-Parkinson agent, piribedil, in rodents: mediation by dopamine D2 receptors

1 reference

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Induction of hyperlocomotion in mice exposed to a novel environment by inhibition of serotonin reuptake. A pharmacological characterization of diverse classes of antidepressant agents

1 reference

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Acute selective serotonin reuptake inhibitors increase conditioned fear expression: blockade with a 5-HT(2C) receptor antagonist

1 reference

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Serotonin 2C receptors within the basolateral amygdala induce acute fear-like responses in an open-field environment

1 reference

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Control of dorsal raphe serotonergic neurons by the medial prefrontal cortex: Involvement of serotonin-1A, GABA(A), and glutamate receptors.

1 reference

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7 January 2021

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Antidepressant-like activity of selective serotonin reuptake inhibitors combined with a NK1 receptor antagonist in the mouse forced swimming test

1 reference

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7 January 2021

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Cellular basis for the effects of substance P in the periaqueductal gray and dorsal raphe nucleus.

1 reference

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7 January 2021

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Substance P (neurokinin 1) receptor antagonists enhance dorsal raphe neuronal activity.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

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Augmentation of SSRI effects on serotonin by 5-HT2C antagonists: mechanistic studies.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

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NK1 receptor antagonists under investigation for the treatment of affective disorders.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Antidepressant-like effects of neurokinin receptor antagonists in the forced swim test in the rat.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

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Shock-induced ultrasonic vocalization in young adult rats: a model for testing putative anti-anxiety drugs

1 reference

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Citalopram reduces social interaction in rats by activation of serotonin (5-HT)(2C) receptors

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

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Circadian rhythms and the pharmacology of affective illness

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

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Substance P in the medial amygdala: emotional stress-sensitive release and modulation of anxiety-related behavior in rats

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

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Stress-induced release of substance P in the locus coeruleus modulates cortical noradrenaline release

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

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Neurokinin 1 receptor antagonism promotes active stress coping via enhanced septal 5-HT transmission

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

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Molecular cloning, mutations and effects of NK1 receptor antagonists reveal the human-like pharmacology of gerbil NK1 receptors

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

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Anxiolytic action of a neurokinin1 receptor antagonist in the social interaction test

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

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5-hydroxytryptamine (5-HT)1A autoreceptor adaptive changes in substance P (neurokinin 1) receptor knock-out mice mimic antidepressant-induced desensitization.

1 reference

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Cerebral blood flow changes after treatment of social phobia with the neurokinin-1 antagonist GR205171, citalopram, or placebo

1 reference

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The selective tachykinin neurokinin 1 (NK1) receptor antagonist, GR 205,171, stereospecifically inhibits light-induced phase advances of hamster circadian activity rhythms.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

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Evaluation of serotonin, noradrenaline and dopamine reuptake inhibitors on light-induced phase advances in hamster circadian activity rhythms.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

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GR205171: a novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity

1 reference

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Pharmacological properties of a potent and selective nonpeptide substance P antagonist

1 reference

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Neurokinin 1 receptor antagonism requires norepinephrine to increase serotonin function

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

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Buspirone modulates basal and fluoxetine-stimulated dialysate levels of dopamine, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1A receptors and blockade of alpha2-adrenergic receptors underlie its a

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

[3H]GR205171 displays similar NK1 receptor binding profile in gerbil and human brain

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Sustained pharmacological blockade of NK1 substance P receptors causes functional desensitization of dorsal raphe 5-HT 1A autoreceptors in mice

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

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inferred from DOI database lookup

Substance P neurokinin 1 receptor activation within the dorsal raphe nucleus controls serotonin release in the mouse frontal cortex

1 reference

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7 January 2021

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Blockade of substance P (neurokinin 1) receptors enhances extracellular serotonin when combined with a selective serotonin reuptake inhibitor: an in vivo microdialysis study in mice

1 reference

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7 January 2021

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Blockade of 5-HT1A receptors by (+/-)-pindolol potentiates cortical 5-HT outflow, but not antidepressant-like activity of paroxetine: microdialysis and behavioral approaches in 5-HT1A receptor knockout mice.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of neurokinin-I receptor antagonists on the function of 5-HT and noradrenaline neurons

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Sustained blockade of neurokinin-1 receptors enhances serotonin neurotransmission

1 reference

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7 January 2021

based on heuristic

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A comparison of neurokinin 1 receptor knock-out (NK1-/-) and wildtype mice: exploratory behaviour and extracellular noradrenaline concentration in the cerebral cortex of anaesthetised subjects.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

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Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective activation of 5-HT(2C) receptors stimulates GABA-ergic function in the rat substantia nigra pars reticulata: a combined in vivo electrophysiological and neurochemical study

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Distinct mechanism for antidepressant activity by blockade of central substance P receptors

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Demonstration of the efficacy and safety of a novel substance P (NK1) receptor antagonist in major depression

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Immunocytochemical evidence for the existence of substance P receptor (NK1) in serotonin neurons of rat and mouse dorsal raphe nucleus

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Neurokinin NK1- and NK3-immunoreactive neurons in serotonergic cell groups in the rat brain

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Serotonin transporter localization in the hamster suprachiasmatic nucleus

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

The selective neurokinin (NK)(1) antagonist, GR205,171, stereospecifically enhances mesocortical dopaminergic transmission in the rat: a combined dialysis and electrophysiological study

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Pindolol excites dopaminergic and adrenergic neurons, and inhibits serotonergic neurons, by activation of 5-HT1A receptors

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Subcellular distribution and plasticity of neurokinin-1 receptors in the rat substantia nigra and ventral tegmental area

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

No modulatory effect of neurokinin-1 receptor antagonists on serotonin uptake in human and rat brain synaptosomes

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Neurokinins activate local glutamatergic inputs to serotonergic neurons of the dorsal raphe nucleus

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Antidepressant-like behavioral effects of serotonin receptor agonists

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Modulation of brain stem monoamines and gamma-aminobutyric acid by NK1 receptors in rats

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Chronic substance P (NK1) receptor antagonist and conventional antidepressant treatment increases burst firing of monoamine neurones in the locus coeruleus

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Symptom provocation in specific phobia affects the substance P neurokinin-1 receptor system

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

The neurobiology and control of anxious states

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

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The role of monoamines in the actions of established and "novel" antidepressant agents: a critical review

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Anxiolytic properties of the selective, non-peptidergic CRF(1) antagonists, CP154,526 and DMP695: a comparison to other classes of anxiolytic agent

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

(-)-Pindolol increases dialysate concentrations of dopamine and noradrenaline, but not serotonin, in the frontal cortex of freely-moving rats

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective blockade of neurokinin (NK)(1) receptors facilitates the activity of adrenergic pathways projecting to frontal cortex and dorsal hippocampus in rats

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Reciprocal autoreceptor and heteroreceptor control of serotonergic, dopaminergic and noradrenergic transmission in the frontal cortex: relevance to the actions of antidepressant agents

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Reduction of guinea pig pup isolation calls by anxiolytic and antidepressant drugs

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Antidepressants and brain monoaminergic systems: a dimensional approach to understanding their behavioural effects in depression and anxiety disorders

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Agonist and antagonist actions of (-)pindolol at recombinant, human serotonin1A (5-HT1A) receptors

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Dose-dependent influence of buspirone on the activities of selective serotonin reuptake inhibitors in the mouse forced swimming test

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Blockade of tachykinin NK1 receptors attenuates stress-induced rise of extracellular noradrenaline and dopamine in the rat and gerbil medial prefrontal cortex

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacological blockade or genetic deletion of substance P (NK(1)) receptors attenuates neonatal vocalisation in guinea-pigs and mice.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

The substance P (NK1) receptor antagonist L-760735 inhibits fear conditioning in gerbils

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Dual NK(1) antagonists--serotonin reuptake inhibitors as potential antidepressants. Part 2: SAR and activity of benzyloxyphenethyl piperazine derivatives

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Autoradiographic distribution of tachykinin NK2 binding sites in the rat brain: comparison with NK1 and NK3 binding sites

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

5-HT receptor subtypes involved in the anxiogenic-like action and associated Fos response of acute fluoxetine treatment in rats.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Stress-induced vocalisation in adult animals. A valid model of anxiety?

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Behavioral profiles of SSRIs in animal models of depression, anxiety and aggression. Are they all alike?

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Evaluation of the effect of chronic antidepressant treatment on neurokinin-1 receptor expression in the rat brain.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of affect by the lateral septum: implications for neuropsychiatry

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Reduction of substance P after chronic antidepressants treatment in the striatum, substantia nigra and amygdala of the rat.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Substance P receptor expression by inhibitory interneurons of the rat hippocampus: enhanced detection using improved immunocytochemical methods for the preservation and colocalization of GABA and other neuronal markers

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Opinion: NK3 receptor antagonists: the next generation of antipsychotics?

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of neurokinin-1 receptors promotes GABA release at synapses in the rat entorhinal cortex.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Extrinsic and intrinsic substance P innervation of the rat lateral septal area calbindin cells

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Substance P Acts through local circuits within the rat dorsal raphe nucleus to alter serotonergic neuronal activity.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

The gerbil elevated plus-maze II: anxiolytic-like effects of selective neurokinin NK1 receptor antagonists

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.176

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/NPP.2008.176

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18830239

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18830239

ResearchGate publication ID

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