(Q46361020)

21 December 2017

title

Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies (English)

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21 December 2017

author

Julian Downward

9

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21 December 2017

Herbert Budka

object named as

Herbert Budka

7

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author name string

Yasuhiro Kawamoto

1

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21 December 2017

Yoshito Kobayashi

2

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21 December 2017

Yasuyuki Suzuki

3

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21 December 2017

Haruhisa Inoue

4

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21 December 2017

Hidekazu Tomimoto

5

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21 December 2017

Ichiro Akiguchi

6

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21 December 2017

L Miguel Martins

8

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21 December 2017

Ryosuke Takahashi

10

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21 December 2017

publication date

1 October 2008

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21 December 2017

Journal of Neuropathology & Experimental Neurology

published in

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21 December 2017

volume

67

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21 December 2017

issue

10

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21 December 2017

page(s)

984-993

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21 December 2017

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

21 January 2018

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Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

21 January 2018

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The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

21 January 2018

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HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

21 January 2018

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Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2

21 January 2018

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Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis

21 January 2018

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Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways

21 January 2018

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Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

21 January 2018

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Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

21 January 2018

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Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions

21 January 2018

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21 January 2018

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21 January 2018

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Beta-amyloid precursor protein is a direct cleavage target of HtrA2 serine protease. Implications for the physiological function of HtrA2 in the mitochondria.

21 January 2018

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21 January 2018

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10.1097/NEN.0B013E31818809F4

21 January 2018

Identifiers

DOI

1 reference

21 December 2017

1 reference

21 December 2017