(Q46384127)

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Sequences from the low density lipoprotein receptor-related protein (LRP) cytoplasmic domain enhance amyloid beta protein production via the beta-secretase pathway without altering amyloid precursor protein/LRP nuclear signaling

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15772078

Sequences from the low density lipoprotein receptor-related protein (LRP) cytoplasmic domain enhance amyloid beta protein production via the beta-secretase pathway without altering amyloid precursor protein/LRP nuclear signaling (English)

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15772078

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Il-Sang Yoon

1

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15772078

Claus U Pietrzik

2

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15772078

David E Kang

3

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15772078

Edward H Koo

4

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15772078

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16 March 2005

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15772078

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15772078

280

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15772078

20

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15772078

20140-20147

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15772078

LRP: a multifunctional scavenger and signaling receptor

1 reference

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21 January 2018

Diverse role of LDL receptor-related protein in the clearance of proteases and in signaling

1 reference

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21 January 2018

The low-density-lipoprotein receptor-related protein (LRP) is processed by furin in vivo and in vitro.

1 reference

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21 January 2018

v-Src induces Shc binding to tyrosine 63 in the cytoplasmic domain of the LDL receptor-related protein 1.

1 reference

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21 January 2018

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction

1 reference

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21 January 2018

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

Alpha-2 macroglobulin is genetically associated with Alzheimer disease

1 reference

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21 January 2018

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons.

1 reference

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21 January 2018

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

Functional roles for fatty acylated amino-terminal domains in subcellular localization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

X11alpha modulates secretory and endocytic trafficking and metabolism of amyloid precursor protein: mutational analysis of the YENPTY sequence

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

Genome structure and chromosomal mapping of the gene for Fe65L2 interacting with Alzheimer's beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413729200

21 January 2018

Identifiers

10.1074/JBC.M413729200

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15772078

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15772078

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