(Q46403175)

English

Thrombin-activated microglia contribute to death of dopaminergic neurons in rat mesencephalic cultures: dual roles of mitogen-activated protein kinase signaling pathways

scientific article published in August 2005

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scholarly article

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/15789435

Thrombin-activated microglia contribute to death of dopaminergic neurons in rat mesencephalic cultures: dual roles of mitogen-activated protein kinase signaling pathways (English)

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/15789435

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1 reference

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author name string

Da Yong Lee

1

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/15789435

Young J Oh

2

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/15789435

Byung Kwan Jin

3

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/15789435

publication date

1 August 2005

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Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/15789435

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/15789435

51

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/15789435

2

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Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/15789435

98-110

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/15789435

Microglia: activation and their significance in the central nervous system

1 reference

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Thrombin peptide, TP508, stimulates angiogenic responses in animal models of dermal wound healing, in chick chorioallantoic membranes, and in cultured human aortic and microvascular endothelial cells

1 reference

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21 January 2018

Prothrombin kringle-2 activates cultured rat brain microglia.

1 reference

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21 January 2018

Immune function of microglia

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Cyclooxygenase-2 inhibitor ns-398 protects neuronal cultures from lipopolysaccharide-induced neurotoxicity

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Expression and regulation of cyclooxygenase-2 in rat microglia

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Thrombin induces in vivo degeneration of nigral dopaminergic neurones along with the activation of microglia.

1 reference

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7 January 2021

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Thrombin induces nigral dopaminergic neurodegeneration in vivo by altering expression of death-related proteins

1 reference

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Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo.

1 reference

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Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanism

1 reference

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GT1b ganglioside induces death of dopaminergic neurons in rat mesencephalic cultures

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beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis.

1 reference

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Involvement of protease-activated receptor-1 in the in vitro development of mesencephalic dopaminergic neurons.

1 reference

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7 January 2021

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Prothrombin mRNA is expressed by cells of the nervous system.

1 reference

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Inducible nitric-oxide synthase and nitric oxide production in human fetal astrocytes and microglia. A kinetic analysis

1 reference

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Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities.

1 reference

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Inhibition of cyclooxygenase-2 protects motor neurons in an organotypic model of amyotrophic lateral sclerosis

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Activated human microglia produce the excitotoxin quinolinic acid

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p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons

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Serine proteases and brain damage - is there a link?

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Brain glia release factors with opposing actions upon neuronal survival.

1 reference

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7 January 2021

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Caspase-dependent and -independent cell death pathways in primary cultures of mesencephalic dopaminergic neurons after neurotoxin treatment.

1 reference

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FcepsilonRII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial cells.

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7 January 2021

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Involvement of c-Jun N-terminal kinase and caspase 3-like protease in DNA damage-induced, p53-mediated apoptosis of cultured mouse cerebellar granule neurons.

1 reference

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7 January 2021

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p38 MAP kinase is involved in lipopolysaccharide-induced dopaminergic neuronal cell death in rat mesencephalic neuron-glia cultures

1 reference

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Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells.

1 reference

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Glutamate neurotoxicity in mesencephalic dopaminergic neurons in culture

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Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia

1 reference

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Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase

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7 January 2021

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The selective cyclooxygenase-2 inhibitor rofecoxib reduces kainate-induced cell death in the rat hippocampus

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7 January 2021

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Edema from intracerebral hemorrhage: the role of thrombin

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Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway

1 reference

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Effect of different types of thrombin inhibitors on thrombin/thrombomodulin modulated activation of protein C in vitro

1 reference

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Tumor necrosis factor alpha is toxic to embryonic mesencephalic dopamine neurons

1 reference

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Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor

1 reference

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7 January 2021

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Identification and characterization of the thrombin binding sites on fibrin

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In vivo expression of cyclooxygenase-2 in rat brain following intraparenchymal injection of bacterial endotoxin and inflammatory cytokines

1 reference

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Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand.

1 reference

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Thrombin-induced activation of cultured rodent microglia

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7 January 2021

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Etiology and pathogenesis of Parkinson's disease

1 reference

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Mitogen-activated protein kinases activated by lipopolysaccharide and beta-amyloid in cultured rat microglia.

1 reference

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Thrombin induces NO release from cultured rat microglia via protein kinase C, mitogen-activated protein kinase, and NF-kappa B

1 reference

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Trisialoganglioside GT1b induces in vivo degeneration of nigral dopaminergic neurons: role of microglia

1 reference

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MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo

1 reference

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Microglia expressing interleukin-13 undergo cell death and contribute to neuronal survival in vivo

1 reference

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Thrombin peptide, TP508, induces differential gene expression in fibroblasts through a nonproteolytic activation pathway.

1 reference

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7 January 2021

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Neuroprotective signal transduction in model motor neurons exposed to thrombin: G-protein modulation effects on neurite outgrowth, Ca(2+) mobilization, and apoptosis

1 reference

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The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20190

7 January 2021

based on heuristic

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Participation of protease-activated receptor-1 in thrombin-induced microglial activation

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20190

7 January 2021

based on heuristic

inferred from DOI database lookup

Pathogenic role of glial cells in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20190

7 January 2021

based on heuristic

inferred from DOI database lookup

Cyclooxygenase-2 is induced in microglia during chronic cerebral ischemia in humans

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20190

7 January 2021

based on heuristic

inferred from DOI database lookup

Thrombin perturbs neurite outgrowth and induces apoptotic cell death in enriched chick spinal motoneuron cultures through caspase activation

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20190

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of glial cells in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20190

7 January 2021

based on heuristic

inferred from DOI database lookup

Cellular localization of thrombin receptor mRNA in rat brain: expression by mesencephalic dopaminergic neurons and codistribution with prothrombin mRNA.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20190

7 January 2021

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Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20190

7 January 2021

based on heuristic

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Interleukin-13 and -4 induce death of activated microglia

1 reference

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7 January 2021

based on heuristic

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Inhibitors of p38 MAP kinase increase the survival of transplanted dopamine neurons

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20190

7 January 2021

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Inducible nitric oxide synthase expression is selectively induced in astrocytes isolated from adult human brain.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20190

7 January 2021

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Identifiers

10.1002/GLIA.20190

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/15789435

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/15789435

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