(Q46438489)

22 December 2017

title

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling (English)

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22 December 2017

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10

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22 December 2017

Joanne McIlrath

object named as

Joanne McIlrath

5

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Claus Johansen

object named as

Claus Johansen

3

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Lars F. Iversen

object named as

Lars Iversen

11

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author name string

Olga Ananieva

1

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22 December 2017

Joanne Darragh

2

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22 December 2017

Julia M Carr

4

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22 December 2017

Jin Mo Park

6

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22 December 2017

Andrew Wingate

7

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22 December 2017

Claire E Monk

8

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22 December 2017

Rachel Toth

9

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22 December 2017

J Simon C Arthur

12

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22 December 2017

language of work or name

English

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publication date

1 September 2008

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22 December 2017

published in

Nature Immunology

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22 December 2017

volume

9

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22 December 2017

issue

9

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22 December 2017

page(s)

1028-1036

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22 December 2017

Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation.

cites work

1 reference

Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages

21 January 2018

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Essential role of MAPK phosphatase-1 in the negative control of innate immune responses

21 January 2018

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Dynamic and transient remodeling of the macrophage IL-10 promoter during transcription

21 January 2018

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Identification of a macrophage-specific chromatin signature in the IL-10 locus.

21 January 2018

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21 January 2018

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21 January 2018

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7 January 2021

New insights into the regulation of TLR signaling.

1 reference

7 January 2021

Signaling pathways downstream of pattern-recognition receptors and their cross talk

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7 January 2021

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

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7 January 2021

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.

1 reference

7 January 2021

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1 reference

7 January 2021

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

1 reference

7 January 2021

The selectivity of protein kinase inhibitors: a further update

1 reference

7 January 2021

Chemical genetics define the roles of p38alpha and p38beta in acute and chronic inflammation

1 reference

7 January 2021

Generation and characterization of p38beta (MAPK11) gene-targeted mice.

1 reference

7 January 2021

The negative regulation of Toll-like receptor and associated pathways

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7 January 2021

Potential adverse effects associated with inhibition of p38alpha/beta MAP kinases

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7 January 2021

Negative regulation of toll-like receptor-mediated immune responses

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7 January 2021

Feedback control of the protein kinase TAK1 by SAPK2a/p38

1 reference

7 January 2021

Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses

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7 January 2021

MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock

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7 January 2021

Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock.

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7 January 2021

MSK activation and physiological roles

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7 January 2021

MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts

1 reference

7 January 2021

MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14

1 reference

7 January 2021

Mitogen- and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophins.

1 reference

7 January 2021

MSKs are required for the transcription of the nuclear orphan receptors Nur77, Nurr1 and Nor1 downstream of MAPK signalling.

1 reference

7 January 2021

Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response

1 reference

7 January 2021

Role of endogenous IL-10 in LPS-induced STAT3 activation and IL-1 receptor antagonist gene expression

1 reference

7 January 2021

Correlation of temperature and toxicity in murine studies of staphylococcal enterotoxins and toxic shock syndrome toxin 1.

1 reference

7 January 2021

The disconnect between animal models of sepsis and human sepsis

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7 January 2021

Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways.

1 reference

7 January 2021

Synergistic activation of the mkp-1 gene by protein kinase A signaling and USF, but not c-Myc

1 reference

7 January 2021

Cyclic adenosine monophosphate-responsive elements are involved in the transcriptional activation of the human IL-10 gene in monocytic cells

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7 January 2021

Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators

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7 January 2021

Differences in innate defense mechanisms in endotoxemia and polymicrobial septic peritonitis

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7 January 2021

Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival.

1 reference

7 January 2021

The importance of systemic cytokines in the pathogenesis of polymicrobial sepsis and dehydroepiandrosterone treatment in a rodent model

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7 January 2021

Interleukin-10 controls the onset of irreversible septic shock

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7 January 2021

What is the role of interleukin 10 in polymicrobial sepsis: Anti-inflammatory agent or immunosuppressant?

1 reference

7 January 2021

Anti-IL-10 therapeutic strategy using the immunomodulator AS101 in protecting mice from sepsis-induced death: dependence on timing of immunomodulating intervention

1 reference

7 January 2021

Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options

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7 January 2021

IL-12, but not IL-18, is critical to neutrophil activation and resistance to polymicrobial sepsis induced by cecal ligation and puncture

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7 January 2021

Interleukin-10-deficient mice develop chronic enterocolitis

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7 January 2021

Cecal ligation and puncture

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7 January 2021

Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity

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7 January 2021

Identifiers

DOI

10.1038/NI.1644

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22 December 2017

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22 December 2017