(Q46441158)

22 December 2017

review article

1 reference

title

Overcoming hurdles in developing successful drugs targeting chemokine receptors (English)

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22 December 2017

author name string

Thomas J Schall

series ordinal

1

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22 December 2017

Amanda E I Proudfoot

series ordinal

2

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22 December 2017

publication date

15 April 2011

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22 December 2017

Nature Reviews Immunology

published in

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22 December 2017

volume

11

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22 December 2017

issue

5

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22 December 2017

page(s)

355-363

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22 December 2017

The chemokine and chemokine receptor superfamilies and their molecular evolution

cites work

1 reference

Chemokines and leukocyte traffic

21 January 2018

1 reference

21 January 2018

Chemokines and disease

1 reference

Chemokines and their receptors: drug targets in immunity and inflammation

21 January 2018

1 reference

Moving targets: cell migration inhibitors as new anti-inflammatory therapies

21 January 2018

1 reference

The many roles of chemokines and chemokine receptors in inflammation

21 January 2018

1 reference

Inflammation and cancer: back to Virchow?

21 January 2018

1 reference

Maraviroc for previously treated patients with R5 HIV-1 infection

21 January 2018

1 reference

Therapeutic antibodies directed at G protein-coupled receptors

21 January 2018

1 reference

Chemokines and asthma: redundancy of function or a coordinated effort?

21 January 2018

1 reference

Knock out models to dissect chemokine receptor function in vivo

21 January 2018

1 reference

Blood monocytes consist of two principal subsets with distinct migratory properties

21 January 2018

1 reference

Migratory fate and differentiation of blood monocyte subsets

21 January 2018

1 reference

The T cell chemokine receptor CCR7 is internalized on stimulation with ELC, but not with SLC.

21 January 2018

1 reference

Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity

21 January 2018

1 reference

CC chemokine receptor-3 undergoes prolonged ligand-induced internalization

21 January 2018

1 reference

Aminooxypentane-RANTES induces CCR3 activation and internalization of CCR3 from the surface of human eosinophils

21 January 2018

1 reference

CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity

21 January 2018

1 reference

Computer modeling of promoter organization as a tool to study transcriptional coregulation.

21 January 2018

1 reference

Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice

21 January 2018

1 reference

Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis.

21 January 2018

1 reference

Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites

21 January 2018

1 reference

Understanding selective trafficking of lymphocyte subsets

21 January 2018

1 reference

Thymus and activation-regulated chemokine in atopic dermatitis: Serum thymus and activation-regulated chemokine level is closely related with disease activity

21 January 2018

1 reference

Demonstration of TARC and CCR4 mRNA expression and distribution using in situ RT-PCR in the lesional skin of atopic dermatitis

21 January 2018

1 reference

Chemokines and cell migration in secondary lymphoid organs

21 January 2018

1 reference

Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease

21 January 2018

1 reference

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

21 January 2018

1 reference

Experimental arthritis in CC chemokine receptor 2-null mice closely mimics severe human rheumatoid arthritis

21 January 2018

1 reference

Dual role of CCR2 during initiation and progression of collagen-induced arthritis: evidence for regulatory activity of CCR2+ T cells.

21 January 2018

1 reference

Proteolytic activation of alternative CCR1 ligands in inflammation

21 January 2018

1 reference

A randomized controlled trial with an anti-CCL2 (anti-monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis

21 January 2018

1 reference

Modulation of CCR2 in rheumatoid arthritis: a double-blind, randomized, placebo-controlled clinical trial

21 January 2018

1 reference

21 January 2018

1 reference

CCR5 is involved in resolution of inflammation in proteoglycan-induced arthritis

21 January 2018

1 reference

CCR5 blockade in rheumatoid arthritis: a randomised, double-blind, placebo-controlled clinical trial.

21 January 2018

1 reference

Preclinical and clinical investigation of a CCR5 antagonist, AZD5672, in patients with rheumatoid arthritis receiving methotrexate

21 January 2018

1 reference

Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor

21 January 2018

1 reference

Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor

21 January 2018

1 reference

Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis

21 January 2018

1 reference

Chemokine blockade and chronic inflammatory disease: proof of concept in patients with rheumatoid arthritis

21 January 2018

1 reference

CCR1 antagonists: what have we learned from clinical trials

21 January 2018

1 reference

Anti-chemokine small molecule drugs: a promising future?

21 January 2018

1 reference

CCR1+/CCR5+ mononuclear phagocytes accumulate in the central nervous system of patients with multiple sclerosis.

21 January 2018

1 reference

CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions

21 January 2018

1 reference

Microbes in gastrointestinal health and disease

21 January 2018

1 reference

Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease

21 January 2018

1 reference

Determining the potency and molecular mechanism of action of insurmountable antagonists

21 January 2018

1 reference

IL-8 as Antibody Therapeutic Target in Inflammatory Diseases: Reduction of Clinical Activity in Palmoplantar Pustulosis

21 January 2018

1 reference

21 January 2018

1 reference

Role of the cytoplasmic tails of CXCR1 and CXCR2 in mediating leukocyte migration, activation, and regulation

31 March 2020

1 reference

Intraallograft chemokine RNA and protein during rejection of MHC-matched/multiple minor histocompatibility-disparate skin grafts

31 March 2020

1 reference

CCR9 and inflammatory bowel disease

31 March 2020

1 reference

Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis. Findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirt

31 March 2020

1 reference

MLN3897 plus methotrexate in patients with rheumatoid arthritis: safety, efficacy, pharmacokinetics, and pharmacodynamics of an oral CCR1 antagonist in a phase IIa, double-blind, placebo-controlled, randomized, proof-of-concept study

31 March 2020

1 reference

Pharmacokinetic and pharmacodynamic evaluation of the novel CCR1 antagonist CCX354 in healthy human subjects: implications for selection of clinical dose.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21494268

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

International union of pharmacology. XXII. Nomenclature for chemokine receptors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21494268

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRI2972

1 reference

22 December 2017

1 reference

22 December 2017