(Q46448361)

English

N-Propargylamine protects SH-SY5Y cells from apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, through stabilization of mitochondrial membrane and induction of anti-apoptotic Bcl-2.

scientific article published on 22 April 2005

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

N-Propargylamine protects SH-SY5Y cells from apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, through stabilization of mitochondrial membrane and induction of anti-apoptotic Bcl-2. (English)

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

apoptotic process

1 reference

based on heuristic

inferred from title

author name string

H Yi

1

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

W Maruyama

2

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

Y Akao

3

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

T Takahashi

4

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

K Iwasa

5

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

M B H Youdim

6

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

M Naoi

7

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

publication date

22 April 2005

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

Journal of Neural Transmission

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

113

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

1

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

21-32

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

https://scigraph.springernature.com/pub.10.1007/s00702-005-0299-z

0 references

Neuroprotective agents for clinical trials in Parkinson's disease: a systematic assessment

1 reference

https://api.crossref.org/works/10.1007%2FS00702-005-0299-Z

21 January 2018

N-Propargyl-1 (R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-kappaB transcription factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

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A controlled trial of rasagiline in early Parkinson disease: the TEMPO Study

1 reference

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Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

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Alkaloids in mammalian tissues. 2. Synthesis of (+)- and (-)-1-substituted-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines

1 reference

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12 December 2020

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The anti-Parkinson drug rasagiline and its cholinesterase inhibitor derivatives exert neuroprotection unrelated to MAO inhibition in cell culture and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

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Anti-apoptotic function of propargylamine inhibitors of type-B monoamine oxidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

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Propiolaldehyde, a pargyline metabolite that irreversibly inhibits aldehyde dehydrogenase. Isolation from a hepatic microsomal system

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

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Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

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Identity of the active site flavin-peptide fragments from the human "A"-form and the bovine "B"-form of monoamine oxidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

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Aliphatic propargylamines: potent, selective, irreversible monoamine oxidase B inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection via pro-survival protein kinase C isoforms associated with Bcl-2 family members

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-(-)-desmethylselegiline, a metabolite of selegiline [L-(-)-deprenyl], protects mesencephalic dopamine neurons from excitotoxicity in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Future of neuroprotection in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-apoptotic action of anti-Alzheimer drug, TV3326 [(N-propargyl)-(3R)-aminoindan-5-yl]-ethyl methyl carbamate, a novel cholinesterase-monoamine oxidase inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased survival of dopaminergic neurons by rasagiline, a monoamine oxidase B inhibitor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(-)-Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of propiolaldehyde and other metabolites in the pargyline inhibition of rat liver aldehyde dehydrogenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancing effect of rasagiline on superoxide dismutase and catalase activities in the dopaminergic system in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enantio-specific induction of apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopaminergic SH-SY5Y cells: suppression of apoptosis by N-(2-heptyl)-N-methylpropargylamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of MAP kinase in the regulation of amyloid precursor protein processing by novel cholinesterase inhibitors derived from rasagiline

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of structural modification of alkyl N-propargylamines on the selective inhibition of monoamine oxidase B activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurochemical and neuroprotective effects of some aliphatic propargylamines: new selective nonamphetamine-like monoamine oxidase B inhibitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiapoptotic properties of rasagiline, N-propargylamine-1(R)-aminoindan, and its optical (S)-isomer, TV1022.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid microfluorimetric determination of monoamine oxidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An anti-Parkinson's disease drug, N-propargyl-1(R)-aminoindan (rasagiline), enhances expression of anti-apoptotic bcl-2 in human dopaminergic SH-SY5Y cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxins induce apoptosis in dopamine neurons: protection by N-propargylamine-1(R)- and (S)-aminoindan, rasagiline and TV1022

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting programmed cell death in neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The essentiality of Bcl-2, PKC and proteasome–ubiquitin complex activations in the neuroprotective-antiapoptotic action of the anti-Parkinson drug, rasagiline

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selegiline's neuroprotective capacity revisited

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anti-Parkinson drug, rasagiline, prevents apoptotic DNA damage induced by peroxynitrite in human dopaminergic neuroblastoma SH-SY5Y cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of protein kinase C by the anti-Parkinson drug, MAO-B inhibitor, rasagiline and its derivatives, in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel (-)deprenyl-derived selective inhibitors of B-type monoamine oxidase. The relation of structure to their action

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 family: life-or-death switch

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacology of B-type selective monoamine oxidase inhibitors; milestones in (-)-deprenyl research.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondria determine the survival and death in apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, and neuroprotection by propargylamines

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine-derived endogenous N-methyl-(R)-salsolinol: its role in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The importance of propargylamine moiety in the anti-Parkinson drug rasagiline and its derivatives in MAPK-dependent amyloid precursor protein processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00702-005-0299-Z

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

ResearchGate publication ID

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