(Q35120138)

6 August 2017

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title

Targeting programmed cell death in neurodegenerative diseases (English)

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6 August 2017

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2

Serge Przedborski

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6 August 2017

1

Miquel Vila

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12728264

30 December 2023

language of work or name

English

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publication date

1 May 2003

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full work available at URL

6 August 2017

https://www.nature.com/articles/nrn1100.pdf

file format

Portable Document Format

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https://www.nature.com/articles/nrn1100

30 December 2023

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Nature Reviews Neuroscience

30 December 2023

published in

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6 August 2017

volume

4

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6 August 2017

issue

5

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6 August 2017

page(s)

365-375

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https://scigraph.springernature.com/pub.10.1038/nrn1100

6 August 2017

exact match

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31 March 2020

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31 March 2020

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31 March 2020

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Upregulation of Bax protein and increased DNA degradation in ALS spinal cord motor neurons

31 March 2020

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31 March 2020

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Lack of apoptosis in mice with ALS

31 March 2020

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Motor neuronal death in sporadic amyotrophic lateral sclerosis (ALS) is not apoptotic. A comparative study of ALS and chronic aluminium chloride neurotoxicity in New Zealand white rabbits

31 March 2020

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The prostate apoptosis response-4 protein participates in motor neuron degeneration in amyotrophic lateral sclerosis

31 March 2020

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Altered expression of bcl-2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons

31 March 2020

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Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis

31 March 2020

1 reference

Apoptosis in amyotrophic lateral sclerosis is not restricted to motor neurons. Bcl-2 expression is increased in unaffected post-central gyrus

31 March 2020

1 reference

Alteration of the Bcl-x/Bax ratio in a transgenic mouse model of amyotrophic lateral sclerosis: evidence for the implication of the p53 signaling pathway

31 March 2020

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Recruitment of the mitochondrial-dependent apoptotic pathway in amyotrophic lateral sclerosis

31 March 2020

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p53 is abnormally elevated and active in the CNS of patients with amyotrophic lateral sclerosis.

31 March 2020

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Motor neuron cell death in a mouse model of FALS is not mediated by the p53 cell survival regulator.

31 March 2020

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Absence of p53: no effect in a transgenic mouse model of familial amyotrophic lateral sclerosis

31 March 2020

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Instrumental activation of bid by caspase-1 in a transgenic mouse model of ALS

31 March 2020

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Inhibition of ICE slows ALS in mice

31 March 2020

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Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

31 March 2020

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X-Linked inhibitor of apoptosis protein is involved in mutant SOD1-mediated neuronal degeneration

31 March 2020

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Programmed cell death of embryonic motoneurons triggered through the Fas death receptor

31 March 2020

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31 March 2020

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31 March 2020

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Trinucleotide repeat length and clinical progression in Huntington's disease

31 March 2020

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

31 March 2020

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DNA end labeling (TUNEL) in Huntington's disease and other neuropathological conditions

31 March 2020

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Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models.

31 March 2020

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Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

31 March 2020

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Caspase-8 is required for cell death induced by expanded polyglutamine repeats.

31 March 2020

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Malonate and 3-nitropropionic acid neurotoxicity are reduced in transgenic mice expressing a caspase-1 dominant-negative mutant.

31 March 2020

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Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

31 March 2020

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Expression of extended polyglutamine sequentially activates initiator and effector caspases

31 March 2020

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Huntingtin's neuroprotective activity occurs via inhibition of procaspase-9 processing

31 March 2020

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Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

31 March 2020

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Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

31 March 2020

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Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

31 March 2020

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Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

31 March 2020

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Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

31 March 2020

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Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

31 March 2020

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Tissue-specific proteolysis of Huntingtin (htt) in human brain: evidence of enhanced levels of N- and C-terminal htt fragments in Huntington's disease striatum.

31 March 2020

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Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

31 March 2020

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Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi

31 March 2020

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From bench to clinic with apoptosis-based therapeutic agents

31 March 2020

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Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

31 March 2020

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Immunohistochemical evidence for apoptosis in Alzheimer's disease.

31 March 2020

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Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death.

31 March 2020

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In situ immunodetection of neuronal caspase-3 activation in Alzheimer disease.

31 March 2020

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Activation of caspase-8 in the Alzheimer's disease brain.

31 March 2020

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Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain.

31 March 2020

1 reference

Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.

31 March 2020

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E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3.

31 March 2020

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Caspase-2 mediates neuronal cell death induced by beta-amyloid

31 March 2020

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Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

31 March 2020

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A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

31 March 2020

1 reference

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

31 March 2020

1 reference

MPTP, MPP+ and mitochondrial function

31 March 2020

1 reference

Studies on the characterization of the inhibitory mechanism of 4'-alkylated 1-methyl-4-phenylpyridinium and phenylpyridine analogues in mitochondria and electron transport particles

31 March 2020

1 reference

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

31 March 2020

1 reference

Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase

31 March 2020

1 reference

Age-dependent penetrance of disease in a transgenic mouse model of familial amyotrophic lateral sclerosis

31 March 2020

1 reference

Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS).

31 March 2020

1 reference

Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis

31 March 2020

1 reference

Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions

31 March 2020

1 reference

Developmental cell death: morphological diversity and multiple mechanisms

31 March 2020

series ordinal

1

1 reference

Journal of Pharmacology and Experimental Therapeutics

30 December 2023

61

288

421

MS Saporito

1999

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30 December 2023

Identifiers

DOI

10.1038/NRN1100

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Dimensions Publication ID

6 August 2017

1004087581

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1 reference