(Q46465757)

22 December 2017

title

Membrane-proximal {alpha}/{beta} stalk interactions differentially regulate integrin activation (English)

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22 December 2017

author name string

Tetsuji Kamata

1

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22 December 2017

Makoto Handa

2

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22 December 2017

Yukiko Sato

3

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22 December 2017

Yasuo Ikeda

4

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22 December 2017

Sadakazu Aiso

5

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22 December 2017

language of work or name

English

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publication date

29 April 2005

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22 December 2017

Journal of Biological Chemistry

published in

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22 December 2017

volume

280

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22 December 2017

issue

26

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22 December 2017

page(s)

24775-24783

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22 December 2017

Integrins: bidirectional, allosteric signaling machines

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21 January 2018

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A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation

21 January 2018

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The role of the CPNKEKEC sequence in the beta(2) subunit I domain in regulation of integrin alpha(L)beta(2) (LFA-1).

21 January 2018

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21 January 2018

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Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster

21 January 2018

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Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor alpha-subunits and platelet glycoprotein IIb.

21 January 2018

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21 January 2018

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Critical residues of integrin alphaIIb subunit for binding of alphaIIbbeta3 (glycoprotein IIb-IIIa) to fibrinogen and ligand-mimetic antibodies (PAC-1, OP-G2, and LJ-CP3).

21 January 2018

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Multiple discontinuous ligand-mimetic antibody binding sites define a ligand binding pocket in integrin alpha(IIb)beta(3).

21 January 2018

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21 January 2018

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The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity.

21 January 2018

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Amino acid residues in the alpha IIb subunit that are critical for ligand binding to integrin alpha IIbbeta 3 are clustered in the beta-propeller model

21 January 2018

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21 January 2018

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Cleavage of the alpha6A subunit is essential for activation of the alpha6Abeta1 integrin by phorbol 12-myristate 13-acetate

21 January 2018

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Human neutrophil elastase proteolytically activates the platelet integrin alphaIIbbeta3 through cleavage of the carboxyl terminus of the alphaIIb subunit heavy chain. Involvement in the potentiation of platelet aggregation

21 January 2018

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Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta 3 subunit

21 January 2018

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21 January 2018

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Disruption of the beta3 663-687 disulfide bridge confers constitutive activity to beta3 integrins

21 January 2018

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Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations

21 January 2018

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Breaking the integrin hinge. A defined structural constraint regulates integrin signaling

21 January 2018

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Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state

21 January 2018

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Divalent cations and ligands induce conformational changes that are highly divergent among beta1 integrins

21 January 2018

1 reference

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A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face

21 January 2018

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Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins

21 January 2018

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Bidirectional transmembrane modulation of integrin alphaIIbbeta3 conformations

21 January 2018

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Critical cysteine residues for regulation of integrin alphaIIbbeta3 are clustered in the epidermal growth factor domains of the beta3 subunit

21 January 2018

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Agonist-specific structural rearrangements of integrin alpha IIbbeta 3. Confirmation of the bent conformation in platelets at rest and after activation

21 January 2018

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Structure of integrin alpha5beta1 in complex with fibronectin

21 January 2018

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Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151.

21 January 2018

1 reference

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Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain

21 January 2018

1 reference

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Identification of functional VEGF receptors on human platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409548200

Thrombospondin-bound integrin-associated protein (CD47) physically and functionally modifies integrin alphaIIbbeta3 by its extracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409548200

21 January 2018

Identifiers

DOI

10.1074/JBC.M409548200

1 reference

22 December 2017

1 reference

22 December 2017