(Q46496885)

English

Genetic determinants of methotrexate toxicity in rheumatoid arthritis patients: a study of polymorphisms affecting methotrexate transport and folate metabolism

scientific article published on 8 July 2008

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scholarly article

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18607581

Genetic determinants of methotrexate toxicity in rheumatoid arthritis patients: a study of polymorphisms affecting methotrexate transport and folate metabolism (English)

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18607581

0 references

rheumatoid arthritis

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

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author name string

Petra Bohanec Grabar

1

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18607581

Dusan Logar

2

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18607581

Boris Lestan

3

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18607581

Vita Dolzan

4

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18607581

publication date

8 July 2008

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18607581

European Journal of Clinical Pharmacology

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18607581

64

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Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18607581

1057-1068

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18607581

11

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18607581

https://scigraph.springernature.com/pub.10.1007/s00228-008-0521-7

0 references

Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics

1 reference

https://api.crossref.org/works/10.1007%2FS00228-008-0521-7

21 January 2018

A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A common mutation A1298C in human methylenetetrahydrofolate reductase gene: association with plasma total homocysteine and folate concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacokinetics of low-dose pulse methotrexate in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ABCB1 C3435T polymorphism influences methotrexate sensitivity in rheumatoid arthritis patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2756GG genotype of methionine synthase reductase gene is more prevalent in rheumatoid arthritis patients treated with methotrexate and is associated with methotrexate-induced nodulosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Patient characteristics associated with high-risk methotrexate concentrations and toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The rheumatoid arthritis patient in the clinic: comparing more than 1,300 consecutive DMARD courses

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of ABCB1 (MDR1) haplotypes derived from G2677T/C3435T on the pharmacokinetics of amlodipine in healthy subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of rheumatoid test procedures--value and critical interpretation of sensitivity and specificity and their effect on pre-test and post-test probability

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Validation of the associations between single nucleotide polymorphisms or haplotypes and responses to disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: a proposal for prospective pharmacogenomic study in clinical practice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simple salting out procedure for extracting DNA from human nucleated cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by single locus and haplotype analyses

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced folate carrier-1 80G>A polymorphism affects methotrexate treatment outcome in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methotrexate related adverse effects in patients with rheumatoid arthritis are associated with the A1298C polymorphism of the MTHFR gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maternal periconceptional vitamin use, genetic variation of infant reduced folate carrier (A80G), and risk of spina bifida

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular aspects of folate and antifolate membrane transport.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of polymorphisms of methionine synthase and methionine synthase reductase on total plasma homocysteine in the NHLBI Family Heart Study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of patient outcome in arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Meta-analysis of treatment termination rates among rheumatoid arthritis patients receiving disease-modifying anti-rheumatic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of creatinine clearance from serum creatinine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Stanford Health Assessment Questionnaire: dimensions and practical applications

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

677C>T and 1298A>C MTHFR polymorphisms affect methotrexate treatment outcome in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphisms in the thymidylate synthase and methylenetetrahydrofolate reductase genes and sensitivity to the low-dose methotrexate therapy in patients with rheumatoid arthritis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of common polymorphisms in reduced folate carrier and gamma-glutamylhydrolase to methotrexate polyglutamate levels in patients with rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacogenomic and metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A "silent" polymorphism in the MDR1 gene changes substrate specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The C677T mutation in the methylenetetrahydrofolate reductase gene: a genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical outcome measures in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biological chemistry of folate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of 3435C>T MDR1 gene polymorphism on rheumatoid arthritis treatment with disease-modifying antirheumatic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene-gene interactions in the folate metabolic pathway influence the risk for acute lymphoblastic leukemia in children

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A polymorphism (80G->A) in the reduced folate carrier gene and its associations with folate status and homocysteinemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role in translation of a triple tandemly repeated sequence in the 5'-untranslated region of human thymidylate synthase mRNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5'-terminal regulatory region of the human gene for thymidylate synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequency of common MDR1 gene variants in a Polish population

1 reference

https://pubmed.ncbi.nlm.nih.gov/18607581

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00228-008-0521-7

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18607581

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18607581

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