(Q33565612)

28 July 2017

title

Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics (English)

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28 July 2017

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lymphoblastic leukemia

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Meyling Cheok

2

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Ching-Hon Pui

7

object named as

Ching-Hon Pui

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28 July 2017

9

Mary V Relling

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28 July 2017

Leo Kager

1

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28 July 2017

Wenjian Yang

3

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28 July 2017

Gianluigi Zaza

4

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28 July 2017

Qing Cheng

5

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28 July 2017

John C Panetta

6

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28 July 2017

James R Downing

8

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28 July 2017

William E Evans

10

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28 July 2017

language of work or name

English

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publication date

1 January 2005

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Journal of Clinical Investigation

28 July 2017

published in

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28 July 2017

volume

115

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28 July 2017

issue

1

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28 July 2017

page(s)

110-117

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''R"--project for statistical computing

28 July 2017

cites work

1 reference

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Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1).

21 June 2018

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Resistance to antifolates

21 June 2018

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The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis

21 June 2018

1 reference

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Loss of multidrug resistance protein 1 expression and folate efflux activity results in a highly concentrative folate transport in human leukemia cells

21 June 2018

1 reference

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Overexpression of wild-type breast cancer resistance protein mediates methotrexate resistance.

21 June 2018

1 reference

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Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system.

21 June 2018

1 reference

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The genetics of the E2F family of transcription factors: shared functions and unique roles

21 June 2018

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21 June 2018

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Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport.

21 June 2018

1 reference

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Purification and properties of a folate-catabolizing enzyme

21 June 2018

1 reference

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Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: results of trial ALL-BFM 90. German-Austrian-Swiss ALL-BFM Study Group

21 June 2018

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Glutamyl hydrolase. pharmacological role and enzymatic characterization

21 June 2018

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Recent advances in the understanding of the mechanism of membrane transport of folates and antifolates.

21 June 2018

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High density synthetic oligonucleotide arrays

21 June 2018

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Biology and treatment of childhood T-lineage acute lymphoblastic leukemia.

21 June 2018

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Overexpression of p21waf1 leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells.

21 June 2018

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Intrinsic and acquired resistance to methotrexate in acute leukemia.

21 June 2018

1 reference

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Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate

21 June 2018

1 reference

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Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia

21 June 2018

1 reference

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Enzymatic synthesis and function of folylpolyglutamates

21 June 2018

1 reference

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The pharmacology and clinical use of methotrexate

21 June 2018

1 reference

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Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates

21 June 2018

1 reference

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Determinants of the sensitivity of human small-cell lung cancer cell lines to methotrexate

21 June 2018

1 reference

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Poor prognosis of children with pre-B acute lymphoblastic leukemia is associated with the t(1;19)(q23;p13): a Pediatric Oncology Group study

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539195

Incorporating prior parameter uncertainty in the design of sampling schedules for pharmacokinetic parameter estimation experiments

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539195

Defective transport as a mechanism of acquired resistance to methotrexate in patients with acute lymphocytic leukemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539195

A substrate specific functional polymorphism of human gamma-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539195

Acute lymphoblastic leukemia with TEL-AML1 fusion has lower expression of genes involved in purine metabolism and lower de novo purine synthesis

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539195

The role of breast cancer resistance protein in acute lymphoblastic leukemia.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539195

Results of Therapy for Acute Lymphoblastic Leukemia in Black and White Children

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539195

Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539195

Classification of pediatric acute lymphoblastic leukemia by gene expression profiling

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539195

De novo purine synthesis inhibition and antileukemic effects of mercaptopurine alone or in combination with methotrexate in vivo

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539195

The association of the TEL-AML1 chromosomal translocation with the accumulation of methotrexate polyglutamates in lymphoblasts and with ploidy in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539195

Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539195

Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539195

P-glycoprotein-mediated methotrexate resistance in CCRF-CEM sublines deficient in methotrexate accumulation due to a point mutation in the reduced folate carrier gene.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539195

Differences in folylpolyglutamate synthetase and dihydrofolate reductase expression in human B-lineage versus T-lineage leukemic lymphoblasts: mechanisms for lineage differences in methotrexate polyglutamylation and cytotoxicity

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539195

Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539195

Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539195

Cytogenetics of pre-B-cell acute lymphoblastic leukemia with emphasis on prognostic implications of the t(1;19)

31 October 2018

1 reference

12 December 2020

Accumulation of high levels of methotrexate polyglutamates in lymphoblasts from children with hyperdiploid (greater than 50 chromosomes) B-lineage acute lymphoblastic leukemia: a Pediatric Oncology Group study

1 reference

12 December 2020

Differences in constitutive and post-methotrexate folylpolyglutamate synthetase activity in B-lineage and T-lineage leukemia

1 reference

12 December 2020

Patient characteristics associated with high-risk methotrexate concentrations and toxicity

1 reference

12 December 2020

E2A-PBX1 fusion in adult acute lymphoblastic leukaemia: biological and clinical features

1 reference

12 December 2020

mRNA expression levels of methotrexate resistance-related proteins in childhood leukemia as determined by a standardized competitive template-based RT-PCR method

1 reference

12 December 2020

Reduced folate carrier gene expression in childhood acute lymphoblastic leukemia: relationship to immunophenotype and ploidy

1 reference

12 December 2020

Accumulation of methotrexate polyglutamates, ploidy and trisomies of both chromosomes 4 and 10 in lymphoblasts from children with B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group Study

1 reference

12 December 2020

Reduced folate carrier expression in acute lymphoblastic leukemia: a mechanism for ploidy but not lineage differences in methotrexate accumulation

1 reference

12 December 2020

Acute lymphoblastic leukemia

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12 December 2020

Identifiers

DOI

10.1172/JCI22477

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28 July 2017

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28 July 2017

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