(Q34157974)

English

Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia

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scholarly article

1 reference

Europe PubMed Central

31 July 2017

Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia (English)

1 reference

Europe PubMed Central

31 July 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

lymphoblastic leukemia

1 reference

based on heuristic

inferred from title

author name string

T W Synold

1

1 reference

Europe PubMed Central

31 July 2017

M V Relling

2

1 reference

Europe PubMed Central

31 July 2017

J M Boyett

3

1 reference

Europe PubMed Central

31 July 2017

G K Rivera

4

1 reference

Europe PubMed Central

31 July 2017

J T Sandlund

5

1 reference

Europe PubMed Central

31 July 2017

H Mahmoud

6

1 reference

Europe PubMed Central

31 July 2017

W M Crist

7

1 reference

Europe PubMed Central

31 July 2017

C H Pui

8

1 reference

Europe PubMed Central

31 July 2017

W E Evans

9

1 reference

Europe PubMed Central

31 July 2017

language of work or name

0 references

publication date

1 November 1994

1 reference

Europe PubMed Central

31 July 2017

Journal of Clinical Investigation

1 reference

Europe PubMed Central

31 July 2017

94

1 reference

Europe PubMed Central

31 July 2017

5

1 reference

Europe PubMed Central

31 July 2017

1996-2001

1 reference

Europe PubMed Central

31 July 2017

Karnofsky memorial lecture. Ode to methotrexate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

5 July 2018

Clinical and biologic relevance of immunologic marker studies in childhood acute lymphoblastic leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

5 July 2018

Biology and treatment of acute lymphoblastic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

5 July 2018

Decreased polyglutamylation of methotrexate in acute lymphoblastic leukemia blasts in adults compared to children with this disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

5 July 2018

Methotrexate cytotoxicity for L5178Y/Asn- lymphoblasts: relationship of dose and duration of exposure to tumor cell viability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

5 July 2018

Enzymatic synthesis of folylpolyglutamates. Characterization of the reaction and its products

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

5 July 2018

Designs for group sequential tests.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

5 July 2018

A methotrexate-resistant human breast cancer cell line with multiple defects, including diminished formation of methotrexate polyglutamates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

5 July 2018

Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

5 July 2018

Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

5 July 2018

Receptor-mediated folate accumulation is regulated by the cellular folate content

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

5 July 2018

High dose methotrexate therapy: Insecure rationale?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

5 July 2018

Impaired polyglutamylation of methotrexate as a cause of resistance in CCRF-CEM cells after short-term, high-dose treatment with this drug

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

5 July 2018

Analysis of methotrexate polyglutamate derivatives in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

5 July 2018

Polyglutamation of methotrexate. Is methotrexate a prodrug?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

5 July 2018

Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

5 July 2018

Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

5 July 2018

Low-dose versus high-dose methotrexate during remission induction in childhood acute lymphoblastic leukemia (Protocol 81-01 update)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

5 July 2018

Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts at diagnosis of childhood acute lymphoblastic leukemia: a pilot prognostic factor analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

5 July 2018

Potocytosis: Sequestration and Transport of Small Molecules by Caveolae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

5 July 2018

Synthesis of methotrexate polyglutamates in L1210 murine leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

5 July 2018

Competitive protein binding assay for methotrexate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

5 July 2018

A program package for simulation and parameter estimation in pharmacokinetic systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

5 July 2018

Folate-dependent enzymes in cultured Chinese hamster cells: Folylpolyglutamate synthetase and its absence in mutants auxotrophic for glycine + adenosine + thymidine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

5 July 2018

Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

28 October 2018

MTX clearance is more important for intermediate-risk ALL.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294625

28 October 2018

Stoichiometric inhibition of mammalian dihydrofolate reductase by the γ-glutamyl metabolite of methotrexate, 4-amino-4-deoxy-N10-methylpteroylglutamyl-γ-glutamate

1 reference

https://pubmed.ncbi.nlm.nih.gov/7525652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differences in constitutive and post-methotrexate folylpolyglutamate synthetase activity in B-lineage and T-lineage leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/7525652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prolonged inhibition of DNA synthesis associated with the accumulation of methotrexate polyglutamates by cultured human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7525652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for the cytotoxic activity of polyglutamate derivatives of methotrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/7525652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/7525652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characteristics of methotrexate polyglutamate formation in cultured hepatic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7525652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aneuploidy and percentage of S-phase cells determined by flow cytometry correlate with cell phenotype in childhood acute leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/7525652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro formation of polyglutamyl derivatives of methotrexate and 7-hydroxymethotrexate in human lymphoblastic leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7525652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of methotrexate polyglutamate accumulation in vitro: effects of cellular folate content

1 reference

https://pubmed.ncbi.nlm.nih.gov/7525652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A direct bone marrow chromosome technique for acute lymphoblastic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/7525652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacodynamics of high-dose methotrexate in acute lymphocytic leukemia. Identification of a relation between concentration and effect

1 reference

https://pubmed.ncbi.nlm.nih.gov/7525652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methotrexate bioavailability after oral and intramuscular administration in children

1 reference

https://pubmed.ncbi.nlm.nih.gov/7525652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intermediate-dose intravenous methotrexate and mercaptopurine therapy for non-T, non-B acute lymphocytic leukemia of childhood: a Pediatric Oncology Group study

1 reference

https://pubmed.ncbi.nlm.nih.gov/7525652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improved outcome in childhood acute lymphoblastic leukaemia with reinforced early treatment and rotational combination chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/7525652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accumulation of high levels of methotrexate polyglutamates in lymphoblasts from children with hyperdiploid (greater than 50 chromosomes) B-lineage acute lymphoblastic leukemia: a Pediatric Oncology Group study

1 reference

https://pubmed.ncbi.nlm.nih.gov/7525652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI117552

1 reference

Europe PubMed Central

31 July 2017

1 reference

Europe PubMed Central

31 July 2017

1 reference

Europe PubMed Central

31 July 2017

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