(Q37351011)

English

Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate

scientific article published on January 1996

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scholarly article

1 reference

Europe PubMed Central

19 August 2017

Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate (English)

1 reference

Europe PubMed Central

19 August 2017

1 reference

based on heuristic

inferred from title

author name string

E Masson

1

1 reference

Europe PubMed Central

19 August 2017

M V Relling

2

1 reference

Europe PubMed Central

19 August 2017

T W Synold

3

1 reference

Europe PubMed Central

19 August 2017

Q Liu

4

1 reference

Europe PubMed Central

19 August 2017

J D Schuetz

5

1 reference

Europe PubMed Central

19 August 2017

J T Sandlund

6

1 reference

Europe PubMed Central

19 August 2017

C H Pui

7

1 reference

Europe PubMed Central

19 August 2017

W E Evans

8

1 reference

Europe PubMed Central

19 August 2017

language of work or name

0 references

publication date

1 January 1996

1 reference

Europe PubMed Central

19 August 2017

Journal of Clinical Investigation

1 reference

Europe PubMed Central

19 August 2017

97

1 reference

Europe PubMed Central

19 August 2017

73-80

1 reference

Europe PubMed Central

19 August 2017

1

1 reference

Europe PubMed Central

19 August 2017

Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507064

6 September 2017

Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507064

6 September 2017

Polyglutamation of methotrexate. Is methotrexate a prodrug?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507064

6 September 2017

Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507064

6 September 2017

Childhood leukemias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507064

14 September 2017

Karnofsky memorial lecture. Ode to methotrexate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507064

28 September 2017

Biology and treatment of acute lymphoblastic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507064

28 September 2017

Results of the LMT81 protocol, a modified LSA2L2 protocol with high dose methotrexate, on 84 children with non-B-cell (lymphoblastic) lymphoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507064

28 September 2017

Decreased polyglutamylation of methotrexate in acute lymphoblastic leukemia blasts in adults compared to children with this disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507064

26 June 2018

High dose methotrexate therapy: Insecure rationale?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507064

26 June 2018

The effects on 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507064

26 June 2018

Analysis of methotrexate polyglutamate derivatives in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507064

26 June 2018

Pharmacokinetic and pharmacodynamic analysis of fluorouracil during 72-hour continuous infusion with and without dipyridamole

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507064

26 June 2018

Low-dose versus high-dose methotrexate during remission induction in childhood acute lymphoblastic leukemia (Protocol 81-01 update)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507064

26 June 2018

Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts at diagnosis of childhood acute lymphoblastic leukemia: a pilot prognostic factor analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507064

26 June 2018

Impact of three methods of treatment intensification on acute lymphoblastic leukemia in children: long-term results of St Jude total therapy study X

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507064

26 June 2018

Treatment of childhood acute lymphoblastic leukemia: results of Dana-Farber Cancer Institute/Children's Hospital Acute Lymphoblastic Leukemia Consortium Protocol 85-01.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507064

2 September 2018

Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507064

2 September 2018

Incidence of cancer in children in the United States. Sex-, race-, and 1-year age-specific rates by histologic type.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507064

2 September 2018

The characteristics of the membrane transport of amethopterin and the naturally occurring folates

1 reference

https://pubmed.ncbi.nlm.nih.gov/8550853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of methotrexate on cellular metabolism: some critical elements in the drug-cell interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/8550853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Urate-oxidase prophylaxis of uric acid-induced renal damage in childhood leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/8550853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characteristics of methotrexate polyglutamate formation in cultured hepatic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8550853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aneuploidy and percentage of S-phase cells determined by flow cytometry correlate with cell phenotype in childhood acute leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/8550853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polyglutamylation, an important element in methotrexate cytotoxicity and selectivity in tumor versus murine granulocytic progenitor cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/8550853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacodynamics of high-dose methotrexate in acute lymphocytic leukemia. Identification of a relation between concentration and effect

1 reference

https://pubmed.ncbi.nlm.nih.gov/8550853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport of folate compounds in L1210 cells: kinetic evidence that folate influx proceeds via the high-affinity transport system for 5-methyltetrahydrofolate and methotrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/8550853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methotrexate bioavailability after oral and intramuscular administration in children

1 reference

https://pubmed.ncbi.nlm.nih.gov/8550853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapy results in five ALL-BFM studies since 1970: implications of risk factors for prognosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8550853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Slow disappearance of peripheral blast cells: an independent risk factor indicating poor prognosis in children with acute lymphoblastic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/8550853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purine de novo synthesis as the basis of synergism of methotrexate and 6-mercaptopurine in human malignant lymphoblasts of different lineages

1 reference

https://pubmed.ncbi.nlm.nih.gov/8550853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-dose methotrexate: is it warranted?

1 reference

https://pubmed.ncbi.nlm.nih.gov/8550853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differences in constitutive and post-methotrexate folylpolyglutamate synthetase activity in B-lineage and T-lineage leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/8550853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Childhood cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/8550853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intensification of treatment and survival in all children with lymphoblastic leukaemia: results of UK Medical Research Council trial UKALL X. Medical Research Council Working Party on Childhood Leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/8550853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Persistence of circulating blasts after 1 week of multiagent chemotherapy confers a poor prognosis in childhood acute lymphoblastic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/8550853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early response to induction therapy as a predictor of disease-free survival and late recurrence of childhood acute lymphoblastic leukemia: a report from the Childrens Cancer Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/8550853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High survival rate in advanced-stage B-cell lymphomas and leukemias without CNS involvement with a short intensive polychemotherapy: results from the French Pediatric Oncology Society of a randomized trial of 216 children

1 reference

https://pubmed.ncbi.nlm.nih.gov/8550853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accumulation of high levels of methotrexate polyglutamates in lymphoblasts from children with hyperdiploid (greater than 50 chromosomes) B-lineage acute lymphoblastic leukemia: a Pediatric Oncology Group study

1 reference

https://pubmed.ncbi.nlm.nih.gov/8550853

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI118409

1 reference

Europe PubMed Central

19 August 2017

1 reference

Europe PubMed Central

19 August 2017

1 reference

Europe PubMed Central

19 August 2017

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0 references

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