(Q46518378)

English

Pharmacokinetic, pharmacodynamic and intracellular effects of PEG-asparaginase in newly diagnosed childhood acute lymphoblastic leukemia: results from a single agent window study

scientific article published on 26 June 2008

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scholarly article

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18580955

Pharmacokinetic, pharmacodynamic and intracellular effects of PEG-asparaginase in newly diagnosed childhood acute lymphoblastic leukemia: results from a single agent window study (English)

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18580955

1 reference

based on heuristic

inferred from title

lymphoblastic leukemia

1 reference

based on heuristic

inferred from title

pharmacokinetics

1 reference

based on heuristic

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pharmacodynamics

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author name string

I M Appel

1

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18580955

K M Kazemier

2

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18580955

J Boos

3

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18580955

C Lanvers

4

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18580955

J Huijmans

5

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18580955

A J P Veerman

6

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18580955

E van Wering

7

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18580955

M L den Boer

8

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18580955

R Pieters

9

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18580955

publication date

26 June 2008

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18580955

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18580955

22

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18580955

9

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18580955

1665-1679

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18580955

https://scigraph.springernature.com/pub.10.1038/leu.2008.165

0 references

Improved outcome for children with acute lymphoblastic leukemia: results of Dana-Farber Consortium Protocol 91-01.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

Relation of cellular drug resistance to long-term clinical outcome in childhood acute lymphoblastic leukaemia.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

Patient stratification based on prednisolone-vincristine-asparaginase resistance profiles in children with acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

Asparaginase-induced derangements of glutamine metabolism: the pathogenetic basis for some drug-related side-effects.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

Use of ?-asparaginase in childhood ALL

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

Characterization of apoptotic phenomena induced by treatment with L-asparaginase in NIH3T3 cells.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

Molecular and genetic characterization of human cell lines resistant to L-asparaginase and albizziin

1 reference

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21 January 2018

Amino acids as regulators of gene expression: molecular mechanisms

1 reference

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21 January 2018

Up-regulation of asparagine synthetase expression is not linked to the clinical response L-asparaginase in pediatric acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

Resistance to different classes of drugs is associated with impaired apoptosis in childhood acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

Mononuclear cells contaminating acute lymphoblastic leukaemic samples tested for cellular drug resistance using the methyl-thiazol-tetrazolium assay

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981 to 1995. Berlin-Frankfurt-Münster.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

Analytical validation of a microplate reader-based method for the therapeutic drug monitoring of L-asparaginase in human serum

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

Lack of asparagine depletion in the cerebrospinal fluid after one intravenous dose of PEG-asparaginase: a window study at initial diagnosis of childhood ALL

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

Measurement of protein using bicinchoninic acid

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

Changes in hypercoagulability by asparaginase: a randomized study between two asparaginases

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

Activation of apoptosis pathways in peripheral blood lymphocytes by in vivo chemotherapy

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

Monitoring of asparaginase activity and asparagine levels in children on different asparaginase preparations.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

Antiapoptotic and proapoptotic action of various amino acids and analogs in starving MOLT-4 cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

In hybridoma cultures, deprivation of any single amino acid leads to apoptotic death, which is suppressed by the expression of the bcl-2 gene

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

Inhibition of glutamine synthetase triggers apoptosis in asparaginase-resistant cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

Glutamine metabolism in lymphocytes: its biochemical, physiological and clinical importance

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

Glycine Inhibition of Asparaginase

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

Comparison of glycine metabolism in mouse lymphoma cells either sensitive or resistant to L-asparaginase

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

21 January 2018

L-asparaginase: clinical, biochemical, pharmacological, and immunological studies

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

7 January 2021

based on heuristic

inferred from DOI database lookup

Clinical relevance of in vitro chemoresistance in childhood acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

7 January 2021

based on heuristic

inferred from DOI database lookup

[In vitro drug resistance as independent prognostic factor in the study COALL-O5-92 Treatment of childhood acute lymphoblastic leukemia; two-tiered classification of treatments based on accepted risk criteria and drug sensitivity profiles in study C

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

7 January 2021

based on heuristic

inferred from DOI database lookup

Prognostic significance of early response to a single dose of asparaginase in childhood acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

7 January 2021

based on heuristic

inferred from DOI database lookup

High cure rate with a moderately intensive treatment regimen in non-high-risk childhood acute lymphoblastic leukemia. Results of protocol ALL VI from the Dutch Childhood Leukemia Study Group

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

7 January 2021

based on heuristic

inferred from DOI database lookup

Pegylated asparaginase (Oncaspar) in children with ALL: drug monitoring in reinduction according to the ALL/NHL-BFM 95 protocols

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

7 January 2021

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Rapid high-performance liquid chromatographic determination of amino acids in synaptosomal extracts

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

7 January 2021

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Developmental haemostasis. Impact for clinical haemostasis laboratories

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

7 January 2021

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Pediatric reference intervals for uncommon bleeding and thrombotic disorders

1 reference

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7 January 2021

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Age-related reference values for activation markers of the coagulation and fibrinolytic systems in children

1 reference

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7 January 2021

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Relation between age, immunophenotype and in vitro drug resistance in 395 children with acute lymphoblastic leukemia--implications for treatment of infants

1 reference

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7 January 2021

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Caspase activation is an early event in anthracycline-induced apoptosis and allows detection of apoptotic cells before they are ingested by phagocytes

1 reference

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7 January 2021

based on heuristic

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The inhibition of glutamine synthetase sensitizes human sarcoma cells to L-asparaginase

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

7 January 2021

based on heuristic

inferred from DOI database lookup

Unphysiological effects contributing to asparaginase toxicity in vitro.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.165

7 January 2021

based on heuristic

inferred from DOI database lookup

L-Asparaginase inhibits the rapamycin-targeted signaling pathway

1 reference

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A METABOLIC DIFFERENCE BETWEEN TWO LINES OF LYMPHOMA 6C3HED CELLS IN RELATION TO ASPARAGINE

1 reference

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7 January 2021

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Insight into the mechanism of asparaginase-induced depletion of antithrombin III in treatment of childhood acute lymphoblastic leukemia

1 reference

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7 January 2021

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inferred from DOI database lookup

Identifiers

10.1038/LEU.2008.165

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18580955

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0 references

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18580955

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