(Q46520345)

22 December 2017

title

Manipulation and analysis of polyketide synthases (English)

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22 December 2017

2

Chaitan Khosla

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22 December 2017

author name string

Pawan Kumar

series ordinal

1

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22 December 2017

Yi Tang

series ordinal

3

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22 December 2017

language of work or name

English

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publication date

1 January 2004

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22 December 2017

published in

Methods in Enzymology

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22 December 2017

volume

388

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22 December 2017

page(s)

269-293

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22 December 2017

Modular organization of genes required for complex polyketide biosynthesis

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7 January 2021

Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase

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The biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506.

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A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity

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7 January 2021

Analysis of four tylosin biosynthetic genes from the tylLM region of the Streptomyces fradiae genome

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7 January 2021

An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea.

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7 January 2021

Harnessing the biosynthetic code: combinations, permutations, and mutations

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7 January 2021

Harnessing the Biosynthetic Potential of Modular Polyketide Synthases

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7 January 2021

Biosynthesis of polyketides

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7 January 2021

Tolerance and specificity of polyketide synthases

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7 January 2021

Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage

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7 January 2021

An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythraea.

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7 January 2021

A hybrid modular polyketide synthase obtained by domain swapping

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7 January 2021

Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering

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7 January 2021

Production of a novel polyketide through the construction of a hybrid polyketide synthase.

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7 January 2021

Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis

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7 January 2021

Engineering broader specificity into an antibiotic-producing polyketide synthase.

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7 January 2021

Novel erythromycins from a recombinant Saccharopolyspora erythraea strain NRRL 2338 pIG1. I. Fermentation, isolation and biological activity

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7 January 2021

Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives

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7 January 2021

A new substrate specificity for acyl transferase domains of the ascomycin polyketide synthase in Streptomyces hygroscopicus.

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7 January 2021

Engineered biosynthesis of novel polyketides

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7 January 2021

The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of Streptomyces

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7 January 2021

Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)

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7 January 2021

Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits

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https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Recombinant polyketide synthesis in Streptomyces: engineering of improved host strains

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https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Construction of new vectors for high-level expression in actinomycetes.

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https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase

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7 January 2021

Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae

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7 January 2021

A host-vector system for analysis and manipulation of rifamycin polyketide biosynthesis in Amycolatopsis mediterranei

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7 January 2021

Functional expression of genes involved in the biosynthesis of the novel polyketide chain extension unit, methoxymalonyl-acyl carrier protein, and engineered biosynthesis of 2-desmethyl-2-methoxy-6-deoxyerythronolide B

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https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

A model of structure and catalysis for ketoreductase domains in modular polyketide synthases

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https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

A multiplasmid approach to preparing large libraries of polyketides

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Engineered biosynthesis of a complete macrolactone in a heterologous host

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

New method for generating deletions and gene replacements in Escherichia coli

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https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Discovering new enzymes and metabolic pathways: conversion of succinate to propionate by Escherichia coli.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

A new enzyme superfamily - the phosphopantetheinyl transferases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Dissecting and exploiting intermodular communication in polyketide synthases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Substrate specificity of the loading didomain of the erythromycin polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

The loading module of rifamycin synthetase is an adenylation-thiolation didomain with substrate tolerance for substituted benzoates

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Assessing the balance between protein-protein interactions and enzyme-substrate interactions in the channeling of intermediates between polyketide synthase modules

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Intermodular communication in modular polyketide synthases: structural and mutational analysis of linker mediated protein-protein recognition

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Biosynthesis of polyketides (other than actinomycete macrolides).

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Engineered intermodular and intramodular polyketide synthase fusions

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

A functional chimeric modular polyketide synthase generated via domain replacement

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

An erythromycin analog produced by reprogramming of polyketide synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Enhancing the modularity of the modular polyketide synthases: transacylation in modular polyketide synthases catalyzed by malonyl-CoA:ACP transacylase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Role of linkers in communication between protein modules

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Molecular recognition of diketide substrates by a beta-ketoacyl-acyl carrier protein synthase domain within a bimodular polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Erythromycin biosynthesis: kinetic studies on a fully active modular polyketide synthase using natural and unnatural substrates

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Purification and characterization of bimodular and trimodular derivatives of the erythromycin polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2988023-6

7 January 2021

10.1016/S0076-6879(04)88023-6

Identifiers

DOI

1 reference

22 December 2017

PubMed ID

15289078

1 reference

22 December 2017