(Q46528298)

22 December 2017

review article

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title

50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond (English)

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22 December 2017

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1

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22 December 2017

Melanie Ott

series ordinal

2

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22 December 2017

publication date

30 December 2014

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22 December 2017

Nature Reviews Molecular Cell Biology

published in

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22 December 2017

volume

16

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22 December 2017

issue

4

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22 December 2017

page(s)

258-264

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22 December 2017

The presence of acetyl groups of histones

cites work

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Development of the acetylation problem, a personal account

31 March 2020

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ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS

31 March 2020

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n-Butyrate causes histone modification in HeLa and Friend erythroleukaemia cells

31 March 2020

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Sodium butyrate inhibits histone deacetylation in cultured cells

31 March 2020

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Butyrate suppression of histone deacetylation leads to accumulation of multiacetylated forms of histones H3 and H4 and increased DNase I sensitivity of the associated DNA sequences

31 March 2020

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Chlamydomonas alpha-tubulin is posttranslationally modified in the flagella during flagellar assembly

31 March 2020

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Monoclonal antibodies specific for an acetylated form of alpha-tubulin recognize the antigen in cilia and flagella from a variety of organisms

31 March 2020

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Identification of an acetylation site of Chlamydomonas alpha-tubulin

31 March 2020

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Microtubules containing acetylated alpha-tubulin in mammalian cells in culture

31 March 2020

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A direct link between core histone acetylation and transcriptionally active chromatin

31 March 2020

1 reference

Genetic evidence for an interaction between SIR3 and histone H4 in the repression of the silent mating loci in Saccharomyces cerevisiae

31 March 2020

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Genetic analysis of histone H4: essential role of lysines subject to reversible acetylation

31 March 2020

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Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML.

31 March 2020

1 reference

Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae.

31 March 2020

1 reference

Histone H4 isoforms acetylated at specific lysine residues define individual chromosomes and chromatin domains in Drosophila polytene nuclei

31 March 2020

1 reference

Specific antibodies reveal ordered and cell-cycle-related use of histone-H4 acetylation sites in mammalian cells

31 March 2020

1 reference

Identification of a gene encoding a yeast histone H4 acetyltransferase

31 March 2020

1 reference

An activity gel assay detects a single, catalytically active histone acetyltransferase subunit in Tetrahymena macronuclei

31 March 2020

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Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation

31 March 2020

1 reference

A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p

31 March 2020

1 reference

Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function

31 March 2020

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RPD1 (SIN3/UME4) is required for maximal activation and repression of diverse yeast genes

31 March 2020

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The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein

31 March 2020

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Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases

31 March 2020

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mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila

31 March 2020

1 reference

31 March 2020

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ESA1 is a histone acetyltransferase that is essential for growth in yeast

31 March 2020

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Esa1p is an essential histone acetyltransferase required for cell cycle progression

31 March 2020

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The TAF(II)250 subunit of TFIID has histone acetyltransferase activity

31 March 2020

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The transcriptional coactivators p300 and CBP are histone acetyltransferases

31 March 2020

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Novel substrate specificity of the histone acetyltransferase activity of HIV-1-Tat interactive protein Tip60

31 March 2020

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Writers and readers of histone acetylation: structure, mechanism, and inhibition

31 March 2020

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Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex

31 March 2020

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Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex

31 March 2020

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Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression

31 March 2020

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Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters

31 March 2020

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A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression

31 March 2020

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Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

31 March 2020

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NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities

31 March 2020

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HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF.

31 March 2020

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Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells

31 March 2020

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Characterization of a human RPD3 ortholog, HDAC3

31 March 2020

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Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family

31 March 2020

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Cloning and characterization of the mouse histone deacetylase-2 gene

31 March 2020

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Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo

31 March 2020

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A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p

31 March 2020

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Three proteins define a class of human histone deacetylases related to yeast Hda1p

31 March 2020

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Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family

31 March 2020

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Molecular cloning and characterization of a novel histone deacetylase HDAC10

31 March 2020

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Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain

31 March 2020

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Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

31 March 2020

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Crystal structure of the histone acetyltransferase domain of the human PCAF transcriptional regulator bound to coenzyme A

31 March 2020

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Solution structure of the catalytic domain of GCN5 histone acetyltransferase bound to coenzyme A

31 March 2020

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Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator

31 March 2020

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Crystal structure of a SIR2 homolog-NAD complex

31 March 2020

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

31 March 2020

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Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity

31 March 2020

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HIV-1 tat transcriptional activity is regulated by acetylation

31 March 2020

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Duration of nuclear NF-kappaB action regulated by reversible acetylation

31 March 2020

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The growing landscape of lysine acetylation links metabolism and cell signalling

31 March 2020

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Structure and ligand of a histone acetyltransferase bromodomain

31 March 2020

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The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p

31 March 2020

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Histone recognition and large-scale structural analysis of the human bromodomain family

31 March 2020

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AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation

31 March 2020

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Transcriptional silencing in yeast is associated with reduced nucleosome acetylation

31 March 2020

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Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

31 March 2020

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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

31 March 2020

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The nexus of chromatin regulation and intermediary metabolism.

31 March 2020

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Acetylation: a regulatory modification to rival phosphorylation?

31 March 2020

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The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

31 March 2020

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SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria

31 March 2020

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The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase

31 March 2020

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Substrate and functional diversity of lysine acetylation revealed by a proteomics survey

31 March 2020

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Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases

31 March 2020

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Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

31 March 2020

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Lysine acetylation targets protein complexes and co-regulates major cellular functions

31 March 2020

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A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.

31 March 2020

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FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor.

31 March 2020

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Reactivation of latent HIV by histone deacetylase inhibitors.

31 March 2020

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Sirtuin activators mimic caloric restriction and delay ageing in metazoans

31 March 2020

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

31 March 2020

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Evidence for a common mechanism of SIRT1 regulation by allosteric activators

31 March 2020

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Selective inhibition of BET bromodomains

31 March 2020

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Suppression of inflammation by a synthetic histone mimic

31 March 2020

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

31 March 2020

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Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor

31 March 2020

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Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome

31 March 2020

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Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways

31 March 2020

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Stoichiometry of site-specific lysine acetylation in an entire proteome.

31 March 2020

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Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae

31 March 2020

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Nonenzymatic acetylation of histones with acetyl-CoA

31 March 2020

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Widespread and enzyme-independent Nε-acetylation and Nε-succinylation of proteins in the chemical conditions of the mitochondrial matrix

31 March 2020

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Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

31 March 2020

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The first identification of lysine malonylation substrates and its regulatory enzyme

31 March 2020

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Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor

31 March 2020

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Modulation of chromatin folding by histone acetylation

31 March 2020

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Disruption of higher-order folding by core histone acetylation dramatically enhances transcription of nucleosomal arrays by RNA polymerase III

31 March 2020

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Acetylation mimics within individual core histone tail domains indicate distinct roles in regulating the stability of higher-order chromatin structure

31 March 2020

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Biological acetylation of natural amino acids

31 March 2020

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12 December 2020

Coenzyme for acetylation, a pantothenic acid derivative.

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12 December 2020

Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression

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12 December 2020

Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase

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12 December 2020

Report on a coenzyme for acetylation.

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12 December 2020

Structure of the site phosphorylated in the phosphorylase b to a reaction

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12 December 2020

Identifiers

DOI

10.1038/NRM3931

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22 December 2017

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22 December 2017