(Q46528408)

22 December 2017

title

Pharmacogenetic effect of the UGT polymorphisms on mycophenolate is modified by calcineurin inhibitors (English)

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22 December 2017

author name string

L'aurelle A Johnson

1

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22 December 2017

William S Oetting

2

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22 December 2017

Saonli Basu

3

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22 December 2017

Susie Prausa

4

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22 December 2017

Arthur Matas

5

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22 December 2017

Pamala A Jacobson

6

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22 December 2017

publication date

21 June 2008

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22 December 2017

European Journal of Clinical Pharmacology

published in

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22 December 2017

volume

64

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22 December 2017

issue

11

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22 December 2017

page(s)

1047-1056

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22 December 2017

https://scigraph.springernature.com/pub.10.1007/s00228-008-0501-y

exact match

0 references

cites work

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Metabolism of sirolimus in the presence or absence of cyclosporine by genotyped human liver microsomes and recombinant cytochromes P450 3A4 and 3A5

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Clinical pharmacokinetics of mycophenolate mofetil

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12 December 2020

Effects of calcineurin inhibitors on pharmacokinetics of mycophenolic acid and its glucuronide metabolite during the maintenance period following renal transplantation

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12 December 2020

Human UDP-glucuronosyltransferases: metabolism, expression, and disease

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12 December 2020

Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8

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12 December 2020

Correlation of mycophenolic acid pharmacokinetic parameters with side effects in kidney transplant patients treated with mycophenolate mofetil.

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12 December 2020

Long-term changes in mycophenolic acid exposure in combination with tacrolimus and corticosteroids are dose dependent and not reflected by trough plasma concentration: a prospective study in 100 de novo renal allograft recipients

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12 December 2020

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Paradoxical urinary phenytoin metabolite (S)/(R) ratios in CYP2C19*1/*2 patients.

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12 December 2020

Unexpected augmentation of mycophenolic acid pharmacokinetics in renal transplant patients receiving tacrolimus and mycophenolate mofetil in combination therapy, and analogous in vitro findings

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12 December 2020

Identification of the UDP-glucuronosyltransferase isoforms involved in mycophenolic acid phase II metabolism.

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12 December 2020

Amiodarone analog-dependent effects on CYP2C9-mediated metabolism and kinetic profiles

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12 December 2020

The glucuronidation of mycophenolic acid by human liver, kidney and jejunum microsomes

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12 December 2020

The Impact of UGT1A8, UGT1A9, and UGT2B7 Genetic Polymorphisms on the Pharmacokinetic Profile of Mycophenolic Acid After a Single Oral Dose in Healthy Volunteers

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12 December 2020

Multidrug resistance protein 2 genetic polymorphisms influence mycophenolic acid exposure in renal allograft recipients

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12 December 2020

Influence of nonsynonymous polymorphisms of UGT1A8 and UGT2B7 metabolizing enzymes on the formation of phenolic and acyl glucuronides of mycophenolic acid

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12 December 2020

Evidence that tacrolimus augments the bioavailability of mycophenolate mofetil through the inhibition of mycophenolic acid glucuronidation

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12 December 2020

The pharmacokinetic-pharmacodynamic relationship for mycophenolate mofetil in renal transplantation

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12 December 2020

The impact of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T on early mycophenolic acid dose-interval exposure in de novo renal allograft recipients

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12 December 2020

Mycophenolate mofetil pharmacokinetics in transplant patients receiving cyclosporine or tacrolimus in combination therapy

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12 December 2020

Influence of UGT1A8 and UGT2B7 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients

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12 December 2020

Mycophenolic Acid Pharmacodynamics and Pharmacokinetics Provide a Basis for Rational Monitoring Strategies

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12 December 2020

Genetic and nongenetic determinants of between-patient variability in the pharmacokinetics of mycophenolic acid

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12 December 2020

Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3.

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12 December 2020

Mycophenolate mofetil in islet cell transplant: variable pharmacokinetics but good correlation between total and unbound concentrations

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12 December 2020

Influence of the UGT2B7 promoter region and exon 2 polymorphisms and comedications on Acyl-MPAG production in vitro and in adult renal transplant patients

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12 December 2020

Cyclosporine interacts with mycophenolic acid by inhibiting the multidrug resistance-associated protein 2.

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12 December 2020

Explaining variability in mycophenolic acid exposure to optimize mycophenolate mofetil dosing: a population pharmacokinetic meta-analysis of mycophenolic acid in renal transplant recipients.

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12 December 2020

Individualization of mycophenolate mofetil dose in renal transplant recipients.

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12 December 2020

Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue

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12 December 2020

Augmentation of mycophenolate mofetil pharmacokinetics in renal transplant patients receiving Prograf and CellCept in combination therapy

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12 December 2020

Haplotype structures of the UGT1A gene complex in a Japanese population

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12 December 2020

Mycophenolic acid 12-h trough level monitoring in renal transplantation: association with acute rejection and toxicity

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12 December 2020

Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver.

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12 December 2020

The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants

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12 December 2020

10.1007/S00228-008-0501-Y

Identifiers

DOI

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22 December 2017

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22 December 2017