(Q4653665)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P62330

Small GTPase superfamily, ARF/SAR type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P62330

Small GTP-binding protein domain family

1 reference

based on heuristic

inferred from protein domain or family

image

Protein ARF6 PDB 1e0s.png
661 × 698; 265 KB

0 references

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

protein N-terminus binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

3 references

31 October 2017

Separation of membrane trafficking and actin remodeling functions of ARF6 with an effector domain mutant

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

10 references

9 May 2019

Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

TBC1D24, an ARF6-interacting protein, is mutated in familial infantile myoclonic epilepsy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

Structural basis for Arf6-MKLP1 complex formation on the Flemming body responsible for cytokinesis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

ARF6 GTPase protects the post-mitotic midbody from 14-3-3-mediated disintegration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

1 reference

8 April 2019

Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

1 reference

9 May 2019

The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

4 references

9 May 2019

Separation of membrane trafficking and actin remodeling functions of ARF6 with an effector domain mutant

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

4 references

31 October 2017

Separation of membrane trafficking and actin remodeling functions of ARF6 with an effector domain mutant

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

31 October 2017

A Protein Interaction Network for Ecm29 Links the 26 S Proteasome to Molecular Motors and Endosomal Components

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

3 references

31 October 2017

Intracellular distribution of Arf proteins in mammalian cells. Arf6 is uniquely localized to the plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

31 October 2017

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

1 reference

31 October 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

3 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

31 October 2017

A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

6 references

9 May 2019

Intracellular distribution of Arf proteins in mammalian cells. Arf6 is uniquely localized to the plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

1 reference

31 October 2017

AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

intracellular anatomical structure

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

1 reference

9 May 2019

Separation of membrane trafficking and actin remodeling functions of ARF6 with an effector domain mutant

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

extracellular exosome

3 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

31 October 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

31 October 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

recycling endosome membrane

3 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

31 October 2017

MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

3 references

5 references

9 May 2019

Separation of membrane trafficking and actin remodeling functions of ARF6 with an effector domain mutant

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

A Protein Interaction Network for Ecm29 Links the 26 S Proteasome to Molecular Motors and Endosomal Components

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

1 reference

9 May 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

3 references

9 May 2019

Intracellular distribution of Arf proteins in mammalian cells. Arf6 is uniquely localized to the plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

HDA

early endosome membrane

1 reference

9 May 2019

recycling endosome membrane

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

glutamatergic synapse

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

establishment of epithelial cell polarity

biological process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

regulation of filopodium assembly

1 reference

9 May 2019

Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

positive regulation of actin filament polymerization

1 reference

9 May 2019

ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

1 reference

31 October 2017

ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

small GTPase mediated signal transduction

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

regulation of Rac protein signal transduction

1 reference

9 May 2019

ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

nervous system development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

negative regulation of dendrite development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

negative regulation of receptor-mediated endocytosis

1 reference

9 May 2019

A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

1 reference

9 May 2019

ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

myeloid cell apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

cortical actin cytoskeleton organization

1 reference

31 October 2017

Separation of membrane trafficking and actin remodeling functions of ARF6 with an effector domain mutant

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

hepatocyte apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62330&geneProductId=UniProtKB:P62330

intracellular protein transport

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

regulation of neuron projection development

IBA

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

cortical actin cytoskeleton organization

protein localization to endosome

3 references

9 May 2019

MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

synaptic vesicle endocytosis

IBA

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

regulation of dendritic spine development

3 references

1 reference

9 May 2019

ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

maintenance of postsynaptic density structure

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

regulation of presynapse assembly

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

cellular response to nerve growth factor stimulus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

negative regulation of protein localization to cell surface

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

positive regulation of protein secretion

1 reference

9 May 2019

FRMD4A-cytohesin signaling modulates the cellular release of tau.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

positive regulation of protein homodimerization activity

1 reference

9 May 2019

FRMD4A-cytohesin signaling modulates the cellular release of tau.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62330

physically interacts with

1 reference

https://thebiogrid.org/news/227

retrieved

19 April 2020

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

BioGRID

has part(s)

small GTP-binding protein domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P62330

Identifiers

MeSH descriptor ID

D000089982

subject named as

ADP-Ribosylation Factor 6

0 references

MeSH tree code

D08.811.277.040.330.300.400.100.050

0 references

D12.776.157.325.515.100.550

0 references

D12.776.476.338.400.100.050

0 references

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

19 March 2016

1 reference

19 March 2016

1 reference

19 March 2016

1 reference

19 March 2016

1 reference

19 March 2016

1 reference

19 March 2016

1 reference

19 March 2016

1 reference

19 March 2016

1 reference

19 March 2016

1 reference

19 March 2016

1 reference

19 March 2016

1 reference

19 March 2016

1 reference

19 March 2016

1 reference

19 March 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference