(Q46538478)

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12 January 2020

title

St. John's Wort modulates the toxicities and pharmacokinetics of CPT-11 (irinotecan) in rats (English)

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12 January 2020

1 reference

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1

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12 January 2020

author name string

Xiaoxia Yang

2

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12 January 2020

Paul Chi-Liu Ho

3

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12 January 2020

Eli Chan

4

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12 January 2020

Sui Yung Chan

5

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12 January 2020

Congjian Xu

6

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12 January 2020

Xiaotian Li

7

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12 January 2020

Yi-Zhun Zhu

8

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12 January 2020

Wei Duan

9

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12 January 2020

Xiao Chen

10

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12 January 2020

Min Huang

11

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12 January 2020

Hongyuan Yang

12

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12 January 2020

Shufeng Zhou

13

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12 January 2020

publication date

8 June 2005

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12 January 2020

published in

Pharmaceutical Research

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12 January 2020

volume

22

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12 January 2020

issue

6

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12 January 2020

page(s)

902-914

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CPT-11 Converting Enzyme from Rat Serum: Purification and Some Properties

12 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS11095-005-4585-0

Metabolic activation of CPT-11, 7-ethyl-10-[4-(1-piperidino)-1- piperidino]carbonyloxycamptothecin, a novel antitumor agent, by carboxylesterase

21 January 2018

1 reference

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Drug interactions with St. John's Wort (Hypericum perforatum): a review of the clinical evidence

21 January 2018

2 references

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21 January 2018

12 December 2020

Effects of St. John's wort on irinotecan metabolism

1 reference

https://api.crossref.org/works/10.1007%2FS11095-005-4585-0

Pharmacokinetic interrelationships of irinotecan (CPT-11) and its three major plasma metabolites in patients enrolled in phase I/II trials

21 January 2018

1 reference

12 December 2020

Gastrointestinal toxicity or irinotecan

1 reference

12 December 2020

St John's wort: Prozac from the plant kingdom.

1 reference

12 December 2020

Pharmacokinetic modulation of irinotecan and metabolites by cyclosporin A.

1 reference

12 December 2020

Phase I and pharmacokinetic study of oral irinotecan given once daily for 5 days every 3 weeks in combination with capecitabine in patients with solid tumors

1 reference

12 December 2020

Evolving role of oral chemotherapy for the treatment of patients with neoplasms

1 reference

12 December 2020

Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).

1 reference

12 December 2020

Reduced gastrointestinal toxicity following inhibition of the biliary excretion of irinotecan and its metabolites by probenecid in rats

1 reference

12 December 2020

Pharmacokinetic interactions of drugs with St John's wort

1 reference

12 December 2020

Alleviation of side effects induced by irinotecan hydrochloride (CPT-11) in rats by intravenous infusion

1 reference

12 December 2020

Structural insights into CPT-11 activation by mammalian carboxylesterases

1 reference

12 December 2020

In-vivo and in-vitro anti-inflammatory effect ofEchinacea purpureaandHypericum perforatum

1 reference

12 December 2020

Multiplicity of biliary excretion mechanisms for irinotecan, CPT-11, and its metabolites in rats

1 reference

12 December 2020

Effect of St. John's wort (Hypericum perforatum) on cytochrome P-450 2D6 and 3A4 activity in healthy volunteers

1 reference

12 December 2020

Oral chemotherapy: rationale and future directions

1 reference

12 December 2020

Prevention of intestinal toxic effects and intensification of irinotecan's therapeutic efficacy against murine colon cancer liver metastases by oral administration of the lipopeptide JBT 3002

1 reference

12 December 2020

Effect of P-glycoprotein modulator, cyclosporin A, on the gastrointestinal excretion of irinotecan and its metabolite SN-38 in rats

1 reference

12 December 2020

CPT-11-induced cholinergic effects in cancer patients

1 reference

12 December 2020

Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothec in, a novel water-soluble derivative of camptothecin, against murine tumors

1 reference

12 December 2020

Sensitive HPLC-Fluorescence Method for Irinotecan and Four Major Metabolites in Human Plasma and Saliva: Application to Pharmacokinetic Studies

1 reference

12 December 2020

Phase II study of irinotecan combined with cisplatin in patients with previously untreated small-cell lung cancer. West Japan Lung Cancer Group

1 reference

12 December 2020

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

1 reference

12 December 2020

Transport of SN-38 by the wild type of human ABC transporter ABCG2 and its inhibition by quercetin, a natural flavonoid.

1 reference

12 December 2020

Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against human tumor xenografts: lack of cross-resistance in vivo in tumors with acquired resistance to the topoisomerase I inhi

1 reference

12 December 2020

Identification and properties of a major plasma metabolite of irinotecan (CPT-11) isolated from the plasma of patients

1 reference

12 December 2020

Inhibition of substance P-induced cytokine synthesis by St. John's wort extracts

1 reference

12 December 2020

A model for the mechanism of human topoisomerase I

1 reference

12 December 2020

St. John's Wort (Hypericum perforatum) induces overexpression of multidrug resistance protein 2 (MRP2) in rats: a 30-day ingestion study

1 reference

12 December 2020

Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor

1 reference

12 December 2020

Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA

1 reference

12 December 2020

Intestinal alkalization as a possible preventive mechanism in irinotecan (CPT-11)-induced diarrhea

1 reference

12 December 2020

Phase I study of an oral formulation of irinotecan administered daily for 14 days every 3 weeks in patients with advanced solid tumours

1 reference

12 December 2020

Modified irinotecan hydrochloride (CPT-11) administration schedule improves induction of delayed-onset diarrhea in rats

1 reference

12 December 2020

Liquid chromatographic determination of irinotecan and three major metabolites in human plasma, urine and feces

1 reference

12 December 2020

Phase II study of irinotecan in prior chemotherapy-treated squamous cell carcinoma of the cervix.

1 reference

12 December 2020

1 reference

12 December 2020

Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea

1 reference

12 December 2020

Multiplicity of biliary excretion mechanisms for the camptothecin derivative irinotecan (CPT-11), its metabolite SN-38, and its glucuronide: role of canalicular multispecific organic anion transporter and P-glycoprotein

1 reference

12 December 2020

Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum)

1 reference

12 December 2020

Second thoughts about safety of St John's wort

1 reference

12 December 2020

Acute heart transplant rejection due to Saint John's wort

1 reference

12 December 2020

St John's wort, a herbal antidepressant, activates the steroid X receptor.

1 reference

12 December 2020

Hepatic extraction, metabolism, and biliary excretion of irinotecan in the isolated perfused rat liver

1 reference

12 December 2020

The modulation of irinotecan-induced diarrhoea and pharmacokinetics by three different classes of pharmacologic agents

1 reference

12 December 2020

Thromboxane A2, released by the anti-tumour drug irinotecan, is a novel stimulator of Cl- secretion in isolated rat colon.

1 reference

12 December 2020

Disposition of irinotecan and SN-38 following oral and intravenous irinotecan dosing in mice

1 reference

12 December 2020

St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4

1 reference

12 December 2020

Metabolism of irinotecan (CPT-11) by human hepatic microsomes: participation of cytochrome P-450 3A and drug interactions

1 reference

12 December 2020

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11

1 reference

12 December 2020

The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity

1 reference

12 December 2020

Effect of intracolonic benzalkonium chloride on trinitrobenzene sulphonic acid-induced colitis in the rat

1 reference

12 December 2020

Insights into the pharmacokinetics and pharmacodynamics of irinotecan

1 reference

12 December 2020

Correlations between S and G2 arrest and the cytotoxicity of camptothecin in human colon carcinoma cells.

1 reference

12 December 2020

St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties.

1 reference

12 December 2020

Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2

1 reference

12 December 2020

Biliary excretion of irinotecan and its metabolites

1 reference

12 December 2020

Human liver UDP-glucuronosyltransferase isoforms involved in the glucuronidation of 7-ethyl-10-hydroxycamptothecin

1 reference

12 December 2020

Management of cancer treatment-related diarrhea. Issues and therapeutic strategies

1 reference

12 December 2020

Pathophysiology and therapy of irinotecan-induced delayed-onset diarrhea in patients with advanced colorectal cancer: a prospective assessment

1 reference

12 December 2020

Effect of St John's wort on the pharmacokinetics of fexofenadine

1 reference

12 December 2020

A Comparative Analysis of the Photosensitized Inhibition of Growth-Factor Regulated Protein Kinases by Hypericin-Derivatives

1 reference

12 December 2020

Mechanism of action of camptothecin

1 reference

12 December 2020

Altered irinotecan and SN-38 disposition after intravenous and oral administration of irinotecan in mice bearing human neuroblastoma xenografts

1 reference

12 December 2020

St John's wort and imipramine-induced gene expression profiles identify cellular functions relevant to antidepressant action and novel pharmacogenetic candidates for the phenotype of antidepressant treatment response

1 reference

12 December 2020

Clinical trials with hypericum extracts in patients with depression--results, comparisons, conclusions for therapy with antidepressant drugs

1 reference

12 December 2020

[Successful treatment of clear cell adenocarcinoma of the ovary (OCCA) with a combination of CPT-11 and mitomycin C]

1 reference

12 December 2020

Phase I and pharmacokinetic trial of oral irinotecan administered daily for 5 days every 3 weeks in patients with solid tumors

1 reference

12 December 2020

A phase II study of irinotecan (CPT-11) in patients with advanced squamous cell carcinoma of the cervix

1 reference

12 December 2020

Inhibition of intestinal microflora beta-glucuronidase modifies the distribution of the active metabolite of the antitumor agent, irinotecan hydrochloride (CPT-11) in rats

1 reference

12 December 2020

Hypericin as a non-antioxidant inhibitor of NF-kappa B.

1 reference

12 December 2020

Conversion of irinotecan (CPT-11) to its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), by Human Liver Carboxylesterase

1 reference

12 December 2020

Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats

1 reference

12 December 2020

Irinotecan: mechanisms of tumor resistance and novel strategies for modulating its activity

1 reference

12 December 2020

Active efflux of CPT-11 and its metabolites in human KB-derived cell lines

1 reference

12 December 2020

Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme

1 reference

12 December 2020

[Late phase II clinical study of irinotecan hydrochloride (CPT-11) in the treatment of malignant lymphoma and acute leukemia. The CPT-11 Research Group for Hematological Malignancies]

1 reference

12 December 2020

St John's Wort: effect on CYP3A4 activity

1 reference

12 December 2020

Gefitinib enhances the antitumor activity and oral bioavailability of irinotecan in mice

1 reference

12 December 2020

Novel camptothecin analogues that circumvent ABCG2-associated drug resistance in human tumor cells.

1 reference

12 December 2020

Anti-inflammatory actions of St. John's wort: inhibition of human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1alpha (STAT-1alpha) activation

1 reference

12 December 2020

Clinical pharmacology of anticancer agents in relation to formulations and administration routes

1 reference

12 December 2020

St. John's wort and depression: efficacy, safety and tolerability-an update

1 reference

12 December 2020

Camptothecins: from bench research to hospital wards.

1 reference

12 December 2020

Decreased plasma levels of amitriptyline and its metabolites on comedication with an extract from St. John's wort ( Hypericum perforatum ).

1 reference

12 December 2020

Modulation of irinotecan-induced diarrhea by cotreatment with neomycin in cancer patients

1 reference

12 December 2020

Excretion into gastrointestinal tract of irinotecan lactone and carboxylate forms and their pharmacodynamics in rodents

1 reference

12 December 2020

Cyclooxygenase-2 inhibition with celecoxib enhances antitumor efficacy and reduces diarrhea side effect of CPT-11.

1 reference

12 December 2020

Metabolism of irinotecan (CPT-11) by CYP3A4 and CYP3A5 in humans

1 reference

12 December 2020

Simple and rapid determination of irinotecan and its metabolite SN-38 in plasma by high-performance liquid-chromatography: application to clinical pharmacokinetic studies

1 reference

12 December 2020

Bone morphogenetic protein-7 reduces the severity of colon tissue damage and accelerates the healing of inflammatory bowel disease in rats.

1 reference

12 December 2020

Changes of colonic mucosal microcirculation and histology in two colitis models: an experimental study using intravital microscopy and a new histological scoring system

1 reference

12 December 2020

Indinavir concentrations and St John's wort.

1 reference

12 December 2020

Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1.

1 reference

12 December 2020

Inhibition of thromboxane A(2)-induced Cl(-) secretion by antidiarrhea drug loperamide in isolated rat colon

1 reference

12 December 2020

10.1007/S11095-005-4585-0

Identifiers

DOI

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12 January 2020

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