(Q46542665)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550766%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

title

Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550766%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference

Ikuroh Ohsawa

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550766%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Kiyomi Nishimaki

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550766%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Yayoi Murakami

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550766%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Yuko Suzuki

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550766%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Masahiro Ishikawa

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550766%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Shigeo Ohta

6

1 reference

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8 January 2020

language of work or name

English

0 references

publication date

1 June 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550766%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

published in

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550766%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

volume

28

1 reference

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8 January 2020

issue

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550766%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

page(s)

6239-6249

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550766%20AND%20SRC:MED&resulttype=core&format=json

The lipid peroxidation product 4-hydroxynonenal inhibits neurite outgrowth, disrupts neuronal microtubules, and modifies cellular tubulin.

8 January 2020

cites work

1 reference

12 December 2020

A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal

1 reference

12 December 2020

Mitochondrial oxidative stress in mice lacking the glutathione peroxidase-1 gene

1 reference

12 December 2020

Oxidative stress and HNE conjugation of GLUT3 are increased in the hippocampus of diabetic rats subjected to stress

1 reference

12 December 2020

Deficiency in Mitochondrial Aldehyde Dehydrogenase Increases the Risk for Late-Onset Alzheimer's Disease in the Japanese Population

1 reference

12 December 2020

Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse

1 reference

12 December 2020

In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification.

1 reference

12 December 2020

Two distinct pathways of formation of 4-hydroxynonenal. Mechanisms of nonenzymatic transformation of the 9- and 13-hydroperoxides of linoleic acid to 4-hydroxyalkenals

1 reference

12 December 2020

Expression and activities of aldo-keto oxidoreductases in Alzheimer disease

1 reference

12 December 2020

Applications of the Morris water maze in the study of learning and memory

1 reference

12 December 2020

Neurogranin null mutant mice display performance deficits on spatial learning tasks with anxiety related components

1 reference

12 December 2020

Identification of the enzymatic mechanism of nitroglycerin bioactivation

1 reference

12 December 2020

Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease.

1 reference

12 December 2020

Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men.

1 reference

12 December 2020

Epidemiologic study of the association of low-Km mitochondrial acetaldehyde dehydrogenase genotypes with blood pressure level and the prevalence of hypertension in a general population

1 reference

12 December 2020

Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells

1 reference

12 December 2020

Genetic polymorphisms of alcohol and aldehyde dehydrogenases and risk for esophageal and head and neck cancers

1 reference

12 December 2020

4-Hydroxy-2-nonenal: a product and mediator of oxidative stress

1 reference

12 December 2020

Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene

1 reference

12 December 2020

Oxidation of 4-hydroxy-2-nonenal by succinic semialdehyde dehydrogenase (ALDH5A)

1 reference

12 December 2020

Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration.

1 reference

12 December 2020

Intracellular metabolism of 4-hydroxynonenal

1 reference

12 December 2020

4-hydroxynonenal and neurodegenerative diseases

1 reference

12 December 2020

Genetic deficiency of a mitochondrial aldehyde dehydrogenase increases serum lipid peroxides in community-dwelling females

1 reference

12 December 2020

Motor disturbances in mice with deficiency of the sodium channel gene Scn8a show features of human dystonia

1 reference

12 December 2020

Mitochondrial ALDH2 deficiency as an oxidative stress

1 reference

12 December 2020

Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP.

1 reference

12 December 2020

Mice lacking catalase develop normally but show differential sensitivity to oxidant tissue injury

1 reference

12 December 2020

A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease

1 reference

12 December 2020

Role of human aldehyde dehydrogenases in endobiotic and xenobiotic metabolism.

1 reference

12 December 2020

Pathways towards and away from Alzheimer's disease

1 reference

12 December 2020

Influence of genetic variations of ethanol-metabolizing enzymes on phenotypes of alcohol-related disorders

1 reference

12 December 2020

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region

1 reference

12 December 2020

Hippocampal synaptic modulation by the phosphotyrosine adapter protein ShcC/N-Shc via interaction with the NMDA receptor

1 reference

12 December 2020

Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations

1 reference

12 December 2020

Glutamate receptor 1-immunopositive neurons in the gliotic CA1 area of the mouse hippocampus after pilocarpine-induced status epilepticus

1 reference

12 December 2020

Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease

1 reference

12 December 2020

Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family

1 reference

12 December 2020

Developmental expression of aldehyde dehydrogenase in rat: a comparison of liver and lung development

1 reference

12 December 2020

ALDH2 polymorphisms and bone mineral density in an elderly Japanese population

1 reference

12 December 2020

Adenylyl cyclase type 5 (AC5) is an essential mediator of morphine action

1 reference

12 December 2020

GSK-3 is essential in the pathogenesis of Alzheimer's disease.

1 reference

12 December 2020

pEF-BOS, a powerful mammalian expression vector

1 reference

12 December 2020

Bioactivation of nitroglycerin by the mitochondrial aldehyde dehydrogenase

1 reference

12 December 2020

Role of reduced lipoic acid in the redox regulation of mitochondrial aldehyde dehydrogenase (ALDH-2) activity. Implications for mitochondrial oxidative stress and nitrate tolerance

1 reference

12 December 2020

Membrane-mediated amyloidogenesis and the promotion of oxidative lipid damage by amyloid beta proteins

1 reference

12 December 2020

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.

1 reference

12 December 2020

Cytoprotective role of mitochondrial amyloid beta peptide-binding alcohol dehydrogenase against a cytotoxic aldehyde

1 reference

12 December 2020

The association of mitochondrial aldehyde dehydrogenase gene (ALDH2) polymorphism with susceptibility to late-onset Alzheimer's disease in Chinese

1 reference

12 December 2020

Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism

1 reference

12 December 2020

Astroglial response in the excitotoxically lesioned neostriatum and its projection areas in the rat

1 reference

12 December 2020

Cytoskeletal modifications induced by 4-hydroxynonenal

1 reference

12 December 2020

Characterization of the regulatory elements in the promoter of the human elongation factor-1 alpha gene.

1 reference

12 December 2020

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease

1 reference

12 December 2020

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

1 reference

12 December 2020

Mitochondrial aldehyde dehydrogenase in diabetes associated with mitochondrial tRNA(Leu(UUR)) mutation at position 3243

1 reference

12 December 2020

Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation

1 reference

12 December 2020

Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4.

1 reference

12 December 2020

4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease.

1 reference

12 December 2020

Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease.

1 reference

12 December 2020

Identification of cardiac oxidoreductase(s) involved in the metabolism of the lipid peroxidation-derived aldehyde-4-hydroxynonenal

1 reference

12 December 2020

A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase

1 reference

12 December 2020

Glutathione transferase protects neuronal cultures against four hydroxynonenal toxicity.

1 reference

12 December 2020

Formation and export of the glutathione conjugate of 4-hydroxy-2, 3-E-nonenal (4-HNE) in hepatoma cells

1 reference

12 December 2020

The lipid peroxidation product 4-hydroxynonenal impairs glutamate and glucose transport and choline acetyltransferase activity in NSC-19 motor neuron cells

1 reference

12 December 2020

10.1523/JNEUROSCI.4956-07.2008

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550766%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550766%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference