(Q46553051)

English

Downregulation of protease-activated receptor-1 in human lung fibroblasts is specifically mediated by the prostaglandin E receptor EP2 through cAMP elevation and protein kinase A.

scientific article published in July 2008

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Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18537828

Downregulation of protease-activated receptor-1 in human lung fibroblasts is specifically mediated by the prostaglandin E receptor EP2 through cAMP elevation and protein kinase A. (English)

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18537828

prostaglandin E2

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Elena Sokolova

1

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18537828

Roland Hartig

2

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18537828

Georg Reiser

3

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18537828

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publication date

1 July 2008

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18537828

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18537828

275

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18537828

14

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18537828

3669-3679

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18537828

A novel therapeutic target in various lung diseases: airway proteases and protease-activated receptors

1 reference

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Protease-activated receptor-1 in human lung fibroblasts mediates a negative feedback downregulation via prostaglandin E2.

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Factor Xa stimulates fibroblast procollagen production, proliferation, and calcium signaling via PAR1 activation

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Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1

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Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis

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Prostaglandin E2 inhibits fibroblast to myofibroblast transition via E. prostanoid receptor 2 signaling and cyclic adenosine monophosphate elevation.

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Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1.

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Thrombin differentiates normal lung fibroblasts to a myofibroblast phenotype via the proteolytically activated receptor-1 and a protein kinase C-dependent pathway

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Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors.

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Prostaglandin E(2) protects human lung fibroblasts from cigarette smoke extract-induced apoptosis via EP(2) receptor activation

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Tissue-specific mechanisms for CCN2/CTGF persistence in fibrotic gingiva: interactions between cAMP and MAPK signaling pathways, and prostaglandin E2-EP3 receptor mediated activation of the c-JUN N-terminal kinase

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Prostacyclin analogs inhibit fibroblast contraction of collagen gels through the cAMP-PKA pathway

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Role and regulation of the thrombin receptor (PAR-1) in human melanoma

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Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP.

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Transcriptional regulation of human protease-activated receptor 1: a role for the early growth response-1 protein in prostate cancer

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The early-immediate gene EGR-1 is induced by transforming growth factor-beta and mediates stimulation of collagen gene expression

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Bleomycin upregulates gene expression of angiotensin-converting enzyme via mitogen-activated protein kinase and early growth response 1 transcription factor

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Beta-adrenergic receptor activation inhibits keratinocyte migration via a cyclic adenosine monophosphate-independent mechanism

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Duality of G protein-coupled mechanisms for beta-adrenergic activation of NKCC activity in skeletal muscle

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Transcriptional inhibition of protease-activated receptor-1 expression by prostacyclin in human vascular smooth muscle cells.

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Identifiers

10.1111/J.1742-4658.2008.06511.X

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18537828

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18537828

ResearchGate publication ID

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