(Q46562392)

23 December 2017

title

Abeta25-35 alters Akt activity, resulting in Bad translocation and mitochondrial dysfunction in cerebrovascular endothelial cells (English)

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23 December 2017

author

Ke-Jie Yin

series ordinal

1

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23 December 2017

Chung Y. Hsu

series ordinal

5

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23 December 2017

Jan Xu

series ordinal

4

object named as

Jan Xu

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23 December 2017

2

Jin-Moo Lee

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23 December 2017

Hong Chen

3

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23 December 2017

publication date

1 November 2005

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23 December 2017

Journal of Cerebral Blood Flow & Metabolism

published in

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23 December 2017

volume

25

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23 December 2017

issue

11

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23 December 2017

page(s)

1445-1455

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23 December 2017

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

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Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

21 January 2018

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Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

21 January 2018

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Regulation of neuronal survival by the serine-threonine protein kinase Akt

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Mitochondria and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

BH3-Only proteins-essential initiators of apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Inhibition of NF-kappaB potentiates amyloid beta-mediated neuronal apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Neurotrophin signal transduction in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Bcl-2-family proteins: the role of the BH3 domain in apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Efficient screening of retroviral cDNA expression libraries

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Amyloid beta-peptide alters the distribution of early endosomes and inhibits phosphorylation of Akt in the presence of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Endonuclease G is an apoptotic DNase when released from mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Akt as a mediator of cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Effect of the Alzheimer amyloid fragment Abeta(25-35) on Akt/PKB kinase and survival of PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Vascular basement membrane components and the lesions of Alzheimer's disease: light and electron microscopic analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Toxic effects of beta-amyloid(25-35) on immortalised rat brain endothelial cell: protection by carnosine, homocarnosine and beta-alanine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Involvement of the pleckstrin homology domain in the insulin-stimulated activation of protein kinase B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

In vivo protein transduction: delivery of a biologically active protein into the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Abeta42 generation is toxic to endothelial cells and inhibits eNOS function through an Akt/GSK-3beta signaling-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Superoxide free radical and intracellular calcium mediate A beta(1-42) induced endothelial toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Molecular characterization of mitochondrial apoptosis-inducing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Role of perivascular cells and myocytes in vascular amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Amyloid beta peptide-induced cerebral endothelial cell death involves mitochondrial dysfunction and caspase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Receptor-linked hydrolysis of phosphoinositides and production of prostacyclin in cerebral endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Mechanisms of neuronal degeneration in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

ATM gene regulates oxygen-glucose deprivation-induced nuclear factor-kappaB DNA-binding activity and downstream apoptotic cascade in mouse cerebrovascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

Amyloid beta-peptide induces cell monolayer albumin permeability, impairs glucose transport, and induces apoptosis in vascular endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

7 January 2021

Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: involvement in suppression of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

7 January 2021

Fragments of amyloid beta induce apoptosis in vascular endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

7 January 2021

SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

7 January 2021

Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3'-Kinase/Akt signal transduction pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

7 January 2021

beta-Amyloid induces cerebrovascular endothelial dysfunction in the rat brain.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

7 January 2021

Animal models of cerebral beta-amyloid angiopathy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

7 January 2021

Amyloid-beta induces Smac release via AP-1/Bim activation in cerebral endothelial cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600139

7 January 2021

Identifiers

DOI

10.1038/SJ.JCBFM.9600139

1 reference

23 December 2017

1 reference

23 December 2017